Can remifentanil use in obstetrics be improved by optimal patient-controlled analgesia bolus timing?

Background The safety of patient-controlled i.v. analgesia (PCA) with remifentanil for obstetrical analgesia remains a matter of concern. The efficacy of remifentanil bolus application, that is, the coincidence between pain and remifentanil effect-site concentration, may be improved by forecasting contractions, but it is not known whether such a technique would also improve safety. Methods We recorded pain intensity during labour continuously using a handheld dynamometer in 43 parturients. Using these data, we compared different models in their ability to predict future contractions. In addition, we modelled remifentanil effect-site concentration using three simulated modes of bolus administration, with and without prediction of future contractions. Results The average duration of pain during contractions recorded by the dynamometer was 45 [14 standard deviation (sd)] s. The time interval between painful contractions was highly variable, with a mean of 151 (31 sd) s during the first and 154 (52 sd) s during the second recording. Using a simple algorithm (three-point moving average), the sd of the difference between predicted and observed inter-contraction intervals can be reduced from 0.95 to 0.79 min. However, the coincidence between remifentanil concentration and pain during contraction is not substantially improved when using these models to guide remifentanil bolus application. Conclusions Because of the large variability of inter-contraction intervals, the use of prediction models will not influence the mean remifentanil concentration in-between contractions. Using models predicting future contractions to improve the timing of remifentanil PCA bolus administration will not diminish the need of continuous clinical surveillance and other safety measure

Hexagons become second if symmetry is broken

Pattern formation on the free surface of a magnetic fluid subjected to a magnetic field is investigated experimentally. By tilting the magnetic field the symmetry can be broken in a controllable manner. When increasing the amplitude of the tilted field, the flat surface gives way to liquid ridges. A further increase results in a hysteretic transition to a pattern of stretched hexagons. The instabilities are detected by means of a linear array of magnetic hall sensors and compared with theoretical predictions.Comment: accepted for publication by Physical Review E/Rapid Communicatio

Study of the optimal conditions for NV- center formation in type 1b diamond, using photoluminescence and positron annihilation spectroscopies

We studied the parameters to optimize the production of negatively-charged nitrogen-vacancy color centers (NV-) in type~1b single crystal diamond using proton irradiation followed by thermal annealing under vacuum. Several samples were treated under different irradiation and annealing conditions and characterized by slow positron beam Doppler-broadening and photoluminescence (PL) spectroscopies. At high proton fluences another complex vacancy defect appears limiting the formation of NV-. Concentrations as high as 2.3 x 10^18 cm^-3 of NV- have been estimated from PL measurements. Furthermore, we inferred the trapping coefficient of positrons by NV-. This study brings insight into the production of a high concentration of NV- in diamond, which is of utmost importance in ultra-sensitive magnetometry and quantum hybrid systems applications

Clustering of vacancy defects in high-purity semi-insulating SiC

Positron lifetime spectroscopy was used to study native vacancy defects in semi-insulating silicon carbide. The material is shown to contain (i) vacancy clusters consisting of 4--5 missing atoms and (ii) Si vacancy related negatively charged defects. The total open volume bound to the clusters anticorrelates with the electrical resistivity both in as-grown and annealed material. Our results suggest that Si vacancy related complexes compensate electrically the as-grown material, but migrate to increase the size of the clusters during annealing, leading to loss of resistivity.Comment: 8 pages, 5 figure

Chiral symmetry breaking in hot matter

This series of three lectures covers (a) a basic introduction to symmetry breaking in general and chiral symmetry breaking in QCD, (b) an overview of the present status of lattice data and the knowlegde that we have at finite temperature from chiral perturbation theory. (c) Results obtained from the Nambu--Jona-Lasinio model describing static mesonic properties are discussed as well as the bulk thermodynamic quantities. Divergences that are observed in the elastic quark-antiquark scattering cross-section, reminiscent of the phenomenon of critical opalescence in light scattering, is also discussed. (d) Finally, we deal with the realm of systems out of equilibrium, and examine the effects of a medium dependent condensate in a system of interacting quarks.Comment: 62 LaTex pages, incorporating 23 figures. Lectures given at the eleventh Chris-Engelbrecht Summer School in Theoretical Physics, 4-13 February, 1998, to be published by Springer Verla

Measuring magnetic moments of polydisperse ferrofluids utilizing the inverse Langevin function

The dipole strength of magnetic particles in a suspension is obtained by a graphical rectification of the magnetization curves based on the inverse Langevin function. The method yields the arithmetic and the harmonic mean of the particle distribution. It has an advantage compared to the fitting of magnetization curves to some appropriate mathematical model: It does not rely on assuming a particular distribution function of the particles

Phase Diffusion in Localized Spatio-Temporal Amplitude Chaos

We present numerical simulations of coupled Ginzburg-Landau equations describing parametrically excited waves which reveal persistent dynamics due to the occurrence of phase slips in sequential pairs, with the second phase slip quickly following and negating the first. Of particular interest are solutions where these double phase slips occur irregularly in space and time within a spatially localized region. An effective phase diffusion equation utilizing the long term phase conservation of the solution explains the localization of this new form of amplitude chaos.Comment: 4 pages incl. 5 figures uucompresse

Neutron star properties in a chiral SU(3) model

We investigate various properties of neutron star matter within an effective chiral $SU(3)_L \times SU(3)_R$ model. The predictions of this model are compared with a Walecka-type model. It is demonstrated that the importance of hyperon degrees are strongly depending on the interaction used, even if the equation of state near saturation density is nearly the same in both models. While the Walecka-type model predicts a strange star core with strangeness fraction $f_S \approx 4/3$, the chiral model allows only for $f_S \approx 1/3$ and predicts that $\Sigma^0$, $\Sigma^+$ and $\Xi^0$ will not exist in star, in contrast to the Walecka-type model.Comment: 13 pages, Revtex, 5 figs include

Thermally Induced Fluctuations Below the Onset of Rayleigh-B\'enard Convection

We report quantitative experimental results for the intensity of noise-induced fluctuations below the critical temperature difference $\Delta T_c$ for Rayleigh-B\'enard convection. The structure factor of the fluctuating convection rolls is consistent with the expected rotational invariance of the system. In agreement with predictions based on stochastic hydrodynamic equations, the fluctuation intensity is found to be proportional to $1/\sqrt{-\epsilon}$ where $\epsilon \equiv \Delta T / \Delta T_c -1$. The noise power necessary to explain the measurements agrees with the prediction for thermal noise. (WAC95-1)Comment: 13 pages of text and 4 Figures in a tar-compressed and uuencoded file (using uufiles package). Detailed instructions of unpacking are include