The planar dynamics of airships

The forces and moments acting upon a LTA vehicle are considered in order to develop parameters describing planar motion. Similar expressions for HTA vehicles will be given to emphasize the greater complexity of aerodynamic effects when buoyancy effects cannot be neglected. A brief summary is also given of the use of virtual mass coefficients to calculate loads on airships

Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage.

BACKGROUND: Injury to cells adjacent to an intracerebral hemorrhage (ICH) is likely mediated at least in part by toxins released from the hematoma that initiate complex and interacting injury cascades. Pharmacotherapies targeting a single toxin or pathway, even if consistently effective in controlled experimental models, have a high likelihood of failure in a variable clinical setting. Nuclear factor erythroid-2 related factor 2 (Nrf2) regulates the expression of heme oxygenase-1 (HO-1) and multiple other proteins with antioxidant and antiinflammatory effects, and may be a target of interest after ICH. METHODS: Studies that tested the effect of HO and Nrf2 in models relevant to ICH are summarized, with an effort to reconcile conflicting data by consideration of methodological limitations. RESULTS: In vitro studies demonstrated that Nrf2 activators rapidly increased HO-1 expression in astrocytes, and reduced their vulnerability to hemoglobin or hemin. Modulating HO-1 expression via genetic approaches yielded similar results. Systemic treatment with small molecule Nrf2 activators increased HO-1 expression in perivascular cells, particularly astrocytes. When tested in mouse or rat ICH models, Nrf2 activators were consistently protective, improving barrier function and attenuating edema, inflammation, neuronal loss and neurological deficits. These effects were mimicked by selective astrocyte HO-1 overexpression in transgenic mice. CONCLUSION: Systemic treatment with Nrf2 activators after ICH is protective in rodents. Two compounds, dimethyl fumarate and hemin, are currently approved for treatment of multiple sclerosis and acute porphyria, respectively, and have acceptable safety profiles over years of clinical use. Further development of these drugs as ICH therapeutics seems warranted

Investigation into the use of satellite remote sensing data products as part of a multi-modal marine environmental monitoring network

In this paper it is investigated how conventional in-situ sensor networks can be complemented by the satellite data streams available through numerous platforms orbiting the earth and the combined analyses products available through services such as MyOcean. Despite the numerous benefits associated with the use of satellite remote sensing data products, there are a number of limitations with their use in coastal zones. Here the ability of these data sources to provide contextual awareness, redundancy and increased efficiency to an in-situ sensor network is investigated. The potential use of a variety of chlorophyll and SST data products as additional data sources in the SmartBay monitoring network in Galway Bay, Ireland is analysed. The ultimate goal is to investigate the ability of these products to create a smarter marine monitoring network with increased efficiency. Overall it was found that while care needs to be taken in choosing these products, there was extremely promising performance from a number of these products that would be suitable in the context of a number of applications especially in relation to SST. It was more difficult to come to conclusive results for the chlorophyll analysis

A Reading of Johnny Faustus

Flyer for Fall 1997 ICS Faculty Fellow Lecture by F. Scott Regan.https://scholarworks.bgsu.edu/ics_fellow_lectures/1026/thumbnail.jp

WHEN THE “GOLDEN HOUR” IS DEAD: PREPARING INDIGENOUS GUERRILLA MEDICAL NETWORKS FOR UNCONVENTIONAL CONFLICTS

The capability to treat and recuperate casualties to return to combat is a vital component of a force’s defense strategy. The current luxury of large specialized medical teams and expedient patient evacuations will no longer be available in future unconventional (UW) and guerrilla warfare (GW) conflicts. It is the goal of this research to determine how to prepare a resistance medical network for unconventional conflict. First, historical guerrilla medicine cases are used to show the irrelevance of the current NATO roles of care. A more applicable framework to GW/UW based on treatment goals is proposed. Then, tangible requirements were determined through systems dynamics analysis and modeling. The developed model provides casualty statistics based on these tangible requirements for planners to optimize their medical network. Social network analysis was utilized to determine non-tangible considerations for each stage of care. Finally, these analyses were synthesized into a decision support algorithm to determine the best possible level of care for a given conflict’s medical system. These analyses supported conclusions from historical cases that battlefield mortality is based on the movement of patients and of supplies in denied environments. Ultimately, improving medical interoperability, enhancing the movement of people and supplies, and preparing medical personnel for clandestine operations are required to decrease mortality in denied environments.Outstanding ThesisLieutenant Colonel, United States Air ForceApproved for public release. Distribution is unlimited

Constitutional Law - Right to Travel - Area Restrictions

Area Restrictions-Congressional intent of Passport Act of 1926 and Immigration & Nationality Act of 1952. Zemel v. Rusk, 381 U. S. 1, 85 Sup. Ct. 1271 (1965)

Criminal Procedure - Indictments - Due Process - Former Acquittal

A defendant, once acquitted of murder, may be retried under a manslaughter indictment and convicted of manslaughter, although the evidence presented proved the crime of murder but not that of manslaughter. Commonwealth v. Frazier, 420 Pa. 209, 216 A.2d 337 (1966)

The Legality of Nuremberg

Twenty years have now passed and still the controversy continues as to whether or not the trials at Nuremberg were in compliance with international law. Although the trials of the major war criminals are now left to the historian, they are still of great importance to the formulation of present international law and are therefore of great interest to the legal profession. Throughout the history of man war has plagued our society. At no time prior to the adoption of the Charter of the International Military Tribunal did the creation of war constitute a crime. The basic problem faced by Nuremberg was whether or not the Allies could make the creation of war a crime. In order to answer this question it must first be ascertained whether or not the Allies had jurisdiction to prescribe a mandate of this nature and, secondly, whether or not they had jurisdiction to enforce that mandate

Can modification of surface topographi represent a viable method of biofouling control in marine environments?

Peer Reviewe