Utility of thiocarbamoyl moiety in synthesis of some new sulphur containing heterocyclic compounds and evaluation of their antimicrobial activity

The reaction of N,N'-(1,4-phenylene)bis(2-cyanoacetamide) (1) with phenyl isothiocyanate gave thiocarbamoyl derivative 3, which reacted with α-halocarbonyl compounds in a mixture of ethanol:N,N-dimethylformamide in the presence of triethylamineto afford thiazoles 4, 7, 10 and thiophene12 derivatives. While, when the same reaction was refluxed in a mixture of ethanol:N,N-dimethylformamide only afforded the acyclic compounds 5, 6, 8, 9 and 11, which when refluxed in N,N-dimethylformamide in presence of triethylamine gave the corresponding above thiazole and thiophene derivatives. Moreover, the reaction of compound 3 with dihalo compounds afforded cyclic dithio derivatives 13a, 13b and 14. The newly synthesized compounds were characterized by analytical, spectral data and evaluation of their antimicrobial activities of 4, 7, 14 and 15 have a high antimicrobial activity

Lanthanum(III) potentiometric sensors based on ethyl benzoyl acetate

Modified carbon paste electrode (CPE) and screen printed electrode (SPE) based on ethyl benzoyl acetate (EBA) were prepared and investigated as lanthanum ion selective electrodes. Effect of various plasticizers (o-NPOE, TCP, DBP, DOS, and DOP) and ionophore content was studied. The reaction mechanism between La(III) and β-diketone ionophore at the electrode surface was studied through scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and IR spectra measurement. The best performance was obtained using modified SPE and CPE electrodes with o-NPOE and TCP plasticizers. These electrodes showed potentiometric response with a Nernstian slope of 21.0, 19.5 and 20.5 mV decade−1 over a concentration range from 1.0 × 10−6 to 1.0 × 10−2 mol L−1 with a fast response time of 9, 10 and 13 s over the linear concentration range for modified SPE (electrode I; TCP plasticizer) and two modified CPE plasticized with o-NPOE (electrode II) and TCP (electrode III), respectively. The electrodes exhibited constant potentiometric response in pH range 4–8, 5–8 and 4–7 for electrodes I, II and III, respectively. They showed satisfactory good sensitivity toward lanthanum ions with regard to most common transition metal ions. The sensors were applied for determination of La(III) ion in different water samples (tap water and wastewater) with satisfactory and good reproducibility results. Keywords: SPE, CPE, Lanthanum(III), β-diketone, SEM, ED

Utility of Sulphones in Heterocyclic Synthesis: Synthesis of Some Pyridine, Chromene and Thiophene Derivatives

Phenylsulfonylacetonitrile (1) when reacted with α,β-unsaturated nitriles (2a,b) and/or 2-hydroxynaphthaldehyde yields pyridine derivatives (3a,b) and / or the iminochromene derivative (4) respectively. The behavior of (1) towards some a-halogenated compounds has been investigated

Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism

Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drugâreceptor binding mechanism. Structural, thermal, morphological and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis; infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD); thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form. Keywords: Quinidine, Charge-transfer interaction, Powder X-ray diffraction, Morphology, Thermal analysi

Synthesis of some new 2-substituted-4-sulfamoylphenylazo-thiophene and/or thiazole derivatives as antibacterial agents

<p>Benzoylacetone has been reacted with phenyl isothiocyanate to afford two different thiocarbamoyl derivatives (α-phenylthiocarbamoyl benzoylacetone and benzoyl thioacetanilide) depending upon the base used to perform the reaction. Several new 2-substituted-4-sulfamoylphenylazo-thiophene and/or thiazole derivatives were synthesized by heterocyclization of the thiocarbamoyl derivatives with various halogenated reagents. The synthesized compounds were screened for their antibacterial activities; they showed accepted activities with respect to the control drugs.</p

Preparation of new surface coating based on modified oil-based polymers blended with ZnO and CuZnO NPs for steel protection

Abstract In our paper, we have synthesized modified PEA and alkyd resin by replacing the new source of polyol (SDEA) which was confirmed by different analyses such as IR, and 1HNMR spectra. A series of conformal, novel, low-cost, and eco-friendly hyperbranched modified alkyd and PEA resins were fabricated with bio ZnO, CuO/ZnO) NPs through an ex-situ method for mechanical and anticorrosive coatings. The synthesized biometal oxides NPs and its composite modified alkyd and PEA were confirmed by FTIR, SEM with EDEX, TEM, and TGA, and can be stably dispersed into modified alkyd and PEA resins at a low weight fraction of 1%. The nanocomposite coating was also subjected to various tests to determine their surface adhesion, which ranged from (4B-5B), physico-mechanical characteristics such as scratch hardness, which improved from  2 kg, gloss (100–135) Specific gravity (0.92–0.96) and also chemical resistance test which passed for water, acid, and solvent except alkali, was poor because of the hydrolyzable ester group in the alkyd and PEA resins. The anti-corrosive features of the nanocomposites were investigated through salt spray tests in 5 wt % NaCl. The results indicate that well-dispersed bio ZnO and CuO/ZnO) NPs (1.0%) in the interior of the hyperbranched alkyd and PEA matrix improve the durability and anticorrosive attributes of the composites, such as degree of rusting, which ranged from 5 to 9, blistering size ranged from 6 to 9, and finally, scribe failure, which ranged from 6 to 9 mm. Thus, they exhibit potential applications in eco- friendly surface coatings. The anticorrosion mechanisms of the nanocomposite alkyd and PEA coating were attributed to the synergistic effect of bio ZnO and (CuO/ZnO) NPs and the prepared modified resins are highly rich in nitrogen elements, which might be regarded as a physical barrier layer for steel substrates