Morphological Integration of Soft-Tissue Facial Morphology in Down Syndrome and Siblings

Down syndrome (DS), resulting from trisomy of chromosome 21, is the most common live-born human aneuploidy. The phenotypic expression of trisomy 21 produces variable, though characteristic, facial morphology. Although certain facial features have been documented quantitatively and qualitatively as characteristic of DS (e.g., epicanthic folds, macroglossia, and hypertelorism), all of these traits occur in other craniofacial conditions with an underlying genetic cause. We hypothesize that the typical DS face is integrated differently than the face of non-DS siblings, and that the pattern of morphological integration unique to individuals with DS will yield information about underlying developmental associations between facial regions. We statistically compared morphological integration patterns of immature DS faces (N = 53) with those of non-DS siblings (N = 54), aged 6–12 years using 31 distances estimated from 3D coordinate data representing 17 anthropometric landmarks recorded on 3D digital photographic images. Facial features are affected differentially in DS, as evidenced by statistically significant differences in integration both within and between facial regions. Our results suggest a differential affect of trisomy on facial prominences during craniofacial development

Patient reported frequency of lupus flare: associations with foundation makeup and sunscreen use

Objective: To test the hypothesis that usage of foundation makeup (FM) and sunscreen lotion (SS), used individually or in combination, is associated with significant changes in the likelihood of lupus symptom exacerbation. Methods: Self-reported flare days (SRF) and use of FM and SS products, were retrospectively examined in 80 Caucasian Australian women with ACR classified SLE for a year. Negative binomial regression modelled SRF days (outcome) against independent FMSS variable and covariates: age; diagnosis years; outdoor hours; BMI; stress; immune therapy medication (ITM) use. Results: Statistically significant inverse associations between SRF days and FMSS use were found. Protective effects were statistically significant (p < 0.05) for combined FMSS exposure days (OR 0.998, CI 0.997 - 1.0) and FM alone (OR 0.603, CI 0.363 - 1.0). Significant associations consistent with increased SRF risk were seen in sub-analysis models for participants taking ITM: univariate model (OR 1.968, p = 0.03); multivariate model for FMSS (OR 2.11, CI 1.161 - 3.835); FM days (OR 1.855, CI 1.023 - 3.364). Results show SRF day reduction of 0.15% for each day of product exposure. Conclusion: Study results highlight protective effects of wearing FM with or without SS. This reduction in flare days ultimately has potential to improve quality of life in SLE patients

Dual Mission Scenarios for the Human Lunar Campaign - Performance, Cost and Risk Benefits

Scenarios for human lunar operations with capabilities significantly beyond Constellation Program baseline missions are potentially feasible based on the concept of dual, sequential missions utilizing a common crew and a single Ares I/CEV (Crew Exploration Vehicle). For example, scenarios possible within the scope of baseline technology planning include outpost-based sortie missions and dual sortie missions. Top level cost benefits of these dual sortie scenarios may be estimated by comparison to the Constellation Program reference two-mission-per-year lunar campaign. The primary cost benefit is the accomplishment of Mission B with a "single launch solution" since no Ares I launch is required. Cumulative risk to the crew is lowered since crew exposure to launch risks and Earth return risks are reduced versus comparable Constellation Program reference two-mission-per-year scenarios. Payload-to-the-lunar-surface capability is substantially increased in the Mission B sortie as a result of additional propellant available for Lunar Lander #2 descent. This additional propellant is a result of EDS #2 transferring a smaller stack through trans-lunar injection and using remaining propellant to perform a portion of the lunar orbit insertion (LOI) maneuver. This paper describes these dual mission concepts, including cost, risk and performance benefits per lunar sortie site, and provides an initial feasibility assessment

Recruitment Facilitation and Spatial Pattern Formation in Soft-Bottom Mussel Beds

Mussels (Mytilus edulis) build massive, spatially complex, biogenic structures that alter the biotic and abiotic environment and provide a variety of ecosystem services. Unlike rocky shores, where mussels can attach to the primary substrate, soft sediments are unsuitable for mussel attachment. We used a simple lattice model, field sampling, and field and laboratory experiments to examine facilitation of recruitment (i.e., preferential larval, juvenile, and adult attachment to mussel biogenic structure) and its role in the development of power-law spatial patterns observed in Maine, USA, soft-bottom mussel beds. The model demonstrated that recruitment facilitation produces power-law spatial structure similar to that in natural beds. Field results provided strong evidence for facilitation of recruitment to other mussels—they do not simply map onto a hard-substrate template of gravel and shell hash. Mussels were spatially decoupled from non-mussel hard substrates to which they can potentially recruit. Recent larval recruits were positively correlated with adult mussels, but not with other hard substrates. Mussels made byssal thread attachments to other mussels in much higher proportions than to other hard substrates. In a field experiment, mussel recruitment was highest to live mussels, followed by mussel shell hash and gravel, with almost no recruitment to muddy sand. In a laboratory experiment, evenly dispersed mussels rapidly self-organized into power-law clusters similar to those observed in nature. Collectively, the results indicate that facilitation of recruitment to existing mussels plays a major role in soft-bottom spatial pattern development. The interaction between large-scale resource availability (hard substrate) and local-scale recruitment facilitation may be responsible for creating complex power-law spatial structure in soft-bottom mussel beds

In This Issue [of \u3ci\u3eTESOL Quarterly\u3c/i\u3e, on Language Teacher Identity]

Our decision to propose a special issue of TESOL Quarterly on language teacher identity (LTI) grew out of our growing recognition of the profound embeddedness of LTI within the research, teaching, and policy practices of (multi)lingual professionals and the immense interest generated by LTI work within the disciplines that engage with language education. We use (multi) in (multi)lingual to underscore our desire to move beyond a monolingual lens in TESOL and to highlight potential extensions to the notion of multilingualism, such as (pluri), (trans), (ethno), and (racio). This allows us to complicate the ever-changing, situated, and fluid nature of LTI beyond the essentialist categories often associated with the profession. These extensions, in particular, acknowledge language teachers (LTs) as denizens and creators of conversational borderlands (Anzaldúa, 1987). As such, each of us came to our individual understandings of this embeddedness in our personal and professional lives by different paths, as illustrated by the following narratives from each co-editor. ... Exploring our language teacher identities means understanding our lived and living history. It is to understand and unravel the complexities that are at the core of who we are on all levels—for instance, as multilinguals, scholars, children, teachers, parents, community members, language users, and activists and their intersectionality, all of which shape our classroom practices and pedagogy, which in turn fuel and circle back to shape our language teacher identities. After taking initial steps toward this end, this special issue and the articles herein are intended as an invitation for our readers to join us as we take further steps forth

Measurements of the vertical profile, diurnal variation, and secular change of ClO in the stratosphere over Thule, Greenland, February-March, 1992

We report observations of stratospheric chlorine monoxide over the altitude range approx. 16 to 50 km at Thule, Greenland from Feb. 8 to Mar. 24, 1992. A new, more sensitive ground-based mm-wave spectrometer was employed for these measurements, similar in principle to that used earlier for the discovery of low altitude ClO in the Antarctic springtime. In this report, we discuss different aspects of vertical distribution, secular trends, and diurnal variation of ClO in the Arctic stratosphere, based on a preliminary analysis of our Thule data. We see no evidence for large (approx. 1.2-1.5 ppb) amounts of ClO in the lower stratosphere at any time during February or March, in agreement with UARS-MLS findings for this period, and in marked contrast to findings reported for the Arctic in January. We have some evidence for small enhancements (approx. 0.2-0.5 ppb) in the 18-30 km range in late February-early March, which might be associated with volcanic aerosol, rather than PSC, processing

Observed changes in the vertical profile of stratopheric nitrous oxide at Thule, Greenland, February - March 1992

Using a ground-based mm-wave spectrometer, we have observed stratospheric N2O over Thule, Greenland (76.3 N, 68.4 W) during late February and March, 1992. Vertical profiles of mixing ratio ranging from 16 to 50 km were recovered from molecular emission spectra. The profiles of early March show an abrupt increase in the lower-stratosphere N2O mixing ratio similar to the spring-to-summer change associated with the break up of the Antarctic polar vortex. This increase is correlated with changes in potential vorticity, air temperature, and ozone mixing ratio

A Trust for Whom?: Managing Colorado\u27s 3 Million Acres of State Land

14 pages. Includes biographical information for John M. Evans, Reeves Brown, and Mark A. E. Burget. State Land Board Commissioner Maxine Stewart was also a speaker for this program, but did not submit any written materials. Contents: A trust for whom? managing Colorado\u27s 3 million acres of state land : a critique of the constitutional amendment / prepared by John Evans -- A cattlemen\u27s [sic] perspective of state land management / presented by Reeves Brown -- Remarks outline / Mark A. E. Burget Program was presented on Monday, February 5, 1996 at the offices of Holland & Hart in Denver, Colo. Historically, state trust lands have been managed for public schools revenue. Now there is pressure to protect some state lands as open space. Should trust lands be managed for broader public values? Is this consistent with existing legal mandates? Speakers: State Land Board Commissioner Maxine Stewart; John Evans, Colorado Board of Education; Reeves Brown, Colorado Cattlemen\u27s Association; The Nature Conservancy\u27s Colorado State Director Mark Burget. Special focus on the recently implemented Multiple Use Program and also on how The Nature Conservancy is working with the State Land Board to preserve resources. Center Director Elizabeth Rieke will moderate

A Trust for Whom?: Managing Colorado\u27s 3 Million Acres of State Land

14 pages. Includes biographical information for John M. Evans, Reeves Brown, and Mark A. E. Burget. State Land Board Commissioner Maxine Stewart was also a speaker for this program, but did not submit any written materials. Contents: A trust for whom? managing Colorado\u27s 3 million acres of state land : a critique of the constitutional amendment / prepared by John Evans -- A cattlemen\u27s [sic] perspective of state land management / presented by Reeves Brown -- Remarks outline / Mark A. E. Burget Program was presented on Monday, February 5, 1996 at the offices of Holland & Hart in Denver, Colo. Historically, state trust lands have been managed for public schools revenue. Now there is pressure to protect some state lands as open space. Should trust lands be managed for broader public values? Is this consistent with existing legal mandates? Speakers: State Land Board Commissioner Maxine Stewart; John Evans, Colorado Board of Education; Reeves Brown, Colorado Cattlemen\u27s Association; The Nature Conservancy\u27s Colorado State Director Mark Burget. Special focus on the recently implemented Multiple Use Program and also on how The Nature Conservancy is working with the State Land Board to preserve resources. Center Director Elizabeth Rieke will moderate

Bigraphical Refinement

We propose a mechanism for the vertical refinement of bigraphical reactive systems, based upon a mechanism for limiting observations and utilising the underlying categorical structure of bigraphs. We present a motivating example to demonstrate that the proposed notion of refinement is sensible with respect to the theory of bigraphical reactive systems; and we propose a sufficient condition for guaranteeing the existence of a safety-preserving vertical refinement. We postulate the existence of a complimentary notion of horizontal refinement for bigraphical agents, and finally we discuss the connection of this work to the general refinement of Reeves and Streader.Comment: In Proceedings Refine 2011, arXiv:1106.348