Gay, Iriarte, and Florian : a study of three eighteenth-century fabulists

Thesis (M.A.)--University of Illinois, 1914.Typescript.Includes bibliographical references

A Model of the Deviation between the Intended and the Actual Experiences with Interactive Installations

Interactive installations engage people in different ways, many of which are different than originally intended by the designer. We present a model that illustrates the differences between the intended experience and the actual experience of people. The model is demonstrated through the analysis of one interactive installation at the Science Museum (London) and the various parameters are mapped and visualized. We suggest that the participants of interactive installations engage differently than originally intended by the designer, which can be defined here as "deviation". There are several levels of deviation, and the proposed model will illustrate the critical interaction stages and visualize the deviations. This model offers new tools for designers and curators alike

Neuropsychiatric features of Parkinson's disease in the era prior to the use of dopaminergic therapies

BACKGROUND: Psychosis in Parkinson's disease includes hallucinations and delusions. Other non-psychotic neuropsychiatric features include depression, anxiety and apathy. There is currently controversy over whether psychosis in Parkinson's is an intrinsic part of the disorder or the result of dopaminergic medications. This study aimed to examine a historical cohort of individuals with Parkinson's prior to the use of dopaminergic therapy to assess the prevalence of psychotic and other neuropsychiatric features. METHODS: The case notes of patients with Parkinson's disease admitted to the National Hospital for Neurology and Neurosurgery, London between 1924 and 1946 were examined. Demographic and clinical variables were extracted along with any neuropsychiatric features. Cases meeting criteria for encephalitis lethargica were excluded. RESULTS: 115 cases of individuals with Parkinson's disease were identified. 58 (41.7%) were female. Mean age was 54.0 (SD 9.6) years and mean time since Parkinson's diagnosis was 5.3 (SD 5.7) years. No individuals met criteria for encephalitis lethargica. No cases of hallucinations or delusions were reported. There was one case of an illusion in a patient who was using anticholinergic medication. Other neuropsychiatric features reported were sleep disorder (present in 10, 8.7%), depression (8, 7.0%), memory impairment (5, 4.3%), impulsivity (4, 3.5%), bradyphrenia (4, 3.5%), impaired attention (3, 2.6%), anxiety (1, 0.9%), fatigue (1, 0.9%) and apathy (1, 0.9%). CONCLUSIONS: Prior to the use of dopaminergic therapies, patients with Parkinson's disease admitted to hospital rarely, if ever, reported psychotic symptoms, although other neuropsychiatric symptoms were more prevalent. The main limitation is that a lack of systematic enquiry about psychotic symptoms may have resulted in underreporting

Using linked routinely collected health data to explore the burden of respiratory syncytial virus (RSV) in Scotland

Introduction Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infections (RTIs), particularly bronchiolitis, in young children worldwide. In order to inform policymaking and regulatory decisions regarding novel RSV vaccines and therapeutics, the health and economic burden of RSV needs to be quantified in further detail. Objectives and Approach This project is part of the REspiratory Syncytial virus Consortium in Europe (RESCEU), a collaborative IMI funded EU project assembling routinely collected health data from at least seven European countries to produce detailed estimates of RSV health and economic burden. This study links national data on hospital admissions, deaths, RSV laboratory testing, prescriptions, and maternal/perinatal data. Using this linked data we calculate rates of hospital admissions, intensive care unit (ICU) admissions, and deaths (a) potentially due to RSV, (b) likely due to RSV, and (c) confirmed due to RSV. We also investigate maternal and perinatal characteristics associated with RSV-related episodes. Results RSV is a major cause of hospital admission in Scotland, particularly in children <6 months old. Around 2,000 admissions with a primary diagnosis of bronchiolitis occur in children <12 months old per year, on average, with approximately 75% of these estimated to be due to RSV.  Children with known clinical risk factors, such as prematurity or chronic conditions, are at increased risk of ICU admission and death due to RSV.  Results will be presented on the age- and risk-group specific hospitalisation, ICU admission and mortality rates for RSV-associated RTI in children <5 years old.  The maternal and perinatal characteristics (e.g. maternal smoking, type of delivery, breastfeeding status, birthweight, APGAR score (5 mins), mechanical ventilation, oxygen use) associated with RSV-related RTI hospital episodes will be presented. Conclusion/Implications This is the first study to explore the national burden of RSV in Scotland. Our results demonstrate the benefits of using linked routinely collected data to explore the epidemiology and burden of infectious diseases and inform policymaking and regulatory decisions. Our methodology can be applied to other countries and pathogens

Longitudinal decline in striatal dopamine transporter binding in Parkinson’s disease: associations with apathy and anhedonia

Background: Motivational symptoms such as apathy and anhedonia are common in Parkinson’s disease (PD), respond poorly to treatment, and are hypothesised to share underlying neural mechanisms. Striatal dopaminergic dysfunction is considered central to motivational symptoms in PD but the association has never been examined longitudinally. We investigated whether progression of dopaminergic dysfunction was associated with emergent apathy and anhedonia symptoms in PD. Methods: Longitudinal cohort study of 412 newly diagnosed patients with PD followed over 5 years as part of the Parkinson’s Progression Markers Initiative cohort. Apathy and anhedonia were measured using a composite score derived from relevant items of the 15-item Geriatric Depression Scale (GDS-15) and part I of the MDS-Unified Parkinson’s Disease Rating Scale. Dopaminergic neurodegeneration was measured using repeated striatal dopamine transporter (DAT) imaging. Results: Linear mixed-effects modelling across all contemporaneous data points identified a significant negative relationship between striatal DAT specific binding ratio (SBR) and apathy/anhedonia symptoms, which emerged as PD progressed (interaction:β=−0.09, 95% CI (−0.15 to 0.03), p=0.002). Appearance and subsequent worsening of apathy/anhedonia symptoms began on average 2 years after diagnosis and below a threshold striatal DAT SBR level. The interaction between striatal DAT SBR and time was specific to apathy/anhedonia symptoms, with no evidence of a similar interaction for general depressive symptoms from the GDS-15 (excluding apathy/anhedonia items) (β=−0.06, 95% CI (−0.13 to 0.01)) or motor symptoms (β=0.20, 95% CI (−0.25 to 0.65)). Conclusions: Our findings support a central role for dopaminergic dysfunction in motivational symptoms in PD. Striatal DAT imaging may be a useful indicator of apathy/anhedonia risk that could inform intervention strategies

Research agenda and priorities for Australian and New Zealand paramedicine : A Delphi consensus study

Introduction: The systematic development of a research agenda is essential for coordinated, collaborative, and efficient research endeavours in any discipline. The aim of this study was to create and prioritise a stakeholder-informed, consensus-derived paramedicine research agenda for Australia and New Zealand. Methods: The study utilised a modified Delphi consensus method consisting of three phases. Phase 1, the findings of which were previously published, consisted of a survey of Australian and New Zealand paramedicine stakeholders to inform the subsequent consensus process. Phase 2 contained three Delphi rounds involving key paramedicine profession stakeholders to generate a research agenda. Panellists were asked to rate their agreement with the inclusion of each item using a 5-point Likert scale. Consensus was defined as 80% agreement signalled by ‘Strongly Agree’ and ‘Agree’ responses. Phase 3 involved one additional round of voting to determine the importance and thus establish priorities amongst the final list of agenda items. Results: There were 341 responses to the survey in Phase 1 and thematic analysis produced a provisional agenda consisting of 109 perceived research priorities. Sixty-three key paramedicine profession stakeholders were invited to Phases 2 and 3, of which 56 (88.9%) completed all three rounds in Phase 2, and 43 (68.3%) completed the final Phase 3. Thirty-seven items achieved consensus and were subsequently prioritised constituting the final research agenda. Panellists gave the highest priority to ‘Paramedics role in broader healthcare system’, ‘New and emerging roles in for paramedics’, ‘Patient safety’, ‘System improvement’, and ‘Clinical reasoning processes and models’. Conclusion: Using a modified Delphi consensus method and drawing from a broad range of stakeholders, a 37-item Australian and New Zealand paramedicine research agenda with item prioritisation was developed. The agenda serves to inform industry and other key stakeholders to guide their research endeavours ultimately leading to meaningful and tangible impact within the paramedicine profession

Modeling Evolving Coronal Loops with Observations from STEREO, Hinode, and TRACE

The high densities, long lifetimes, and narrow emission measure distributions observed in coronal loops with apex temperatures near 1 MK are difficult to reconcile with physical models of the solar atmosphere. It has been proposed that the observed loops are actually composed of sub-resolution ``threads'' that have been heated impulsively and are cooling. We apply this heating scenario to nearly simultaneous observations of an evolving post-flare loop arcade observed with the EUVI/\textit{STEREO}, XRT/\textit{Hinode}, and \textit{TRACE} imagers and the EIS spectrometer on \textit{HINODE}. We find that it is possible to reproduce the extended loop lifetime, high electron density, and the narrow differential emission measure with a multi-thread hydrodynamic model provided that the time scale for the energy release is sufficiently short. The model, however, does not reproduce the evolution of the very high temperature emission observed with XRT. In XRT the emission appears diffuse and it may be that this discrepancy is simply due to the difficulty of isolating individual loops at these temperatures. This discrepancy may also reflect fundamental problems with our understanding of post-reconnection dynamics during the conductive cooling phase of loop evolution.Comment: Revised version submitted to ApJ in response to referee's comment

William Pitt and the origins of the loyalist association movement of 1792

© 1996 Cambridge University Press.This article presents new and conclusive evidence to resolve the long-running controversy over whether the loyalist association movement of 1792 was spontaneous or was crafted by government. It shows that Pitt and his colleagues did not know in advance of John Reeves's proposals for the Crown and Anchor association before they were published on 23 November and it suggests who Reeves's original collaborators probably were. It then goes on to show how Pitt and his cousin, Lord Grenville, confronted with many demands and proposals for associations at this time, quickly seized upon the Reeves project as the most adaptable to their own ends and produced a new draft, redefining his proposals in the directions they were prepared to see such a movement take. This they induced Reeves to publish as a second declaration on 26 November and they went on to promote as the example and inspiration for a wider association movement

The Lantern Vol. 28, No. 2, Spring 1961

• A New Bedlam • A Priori • Germ Warfare • Verse for a Sympathy Card • On Lamartine\u27s Crucifix • On Art • Hope • Hymn to the Morning • An Educator Speaks • Come Out • Insemination • A Day\u27s Hope • Laura • Walking Together • 20 September 1960 • 15 October 1960 • The Governor\u27s Dog • One of the Gang • Poem • Knowledge is Freedom • To Conservative Child • Seventeen American Skating Careers at the Zenithhttps://digitalcommons.ursinus.edu/lantern/1080/thumbnail.jp