Tests for sensitisation in occupational medicine practice - the soy bean example

Objective: To determine the prevalence of sensitisation to soy bean measured by specific IgE and skin prick tests (SPTs) and to examine the association between evidence of sensitisation to soy bean allergens and symptoms of allergic disease. Design: Cross-sectional study. Questionnaire survey. A venous blood sample was taken for specific IgE testing, and SPTs for common allergens.and soy bean dust were performed. Setting: Soy bean mill. Participants: A volunteer sample of 22 workers exposed to soy bean dust; the first 20 non-exposed workers presenting to the National Centre for Occupational Health clinic formed the control group. Main outcome measure: Immunological tests for sensitisation and symptoms of respiratory and allergic disease. Results: Eight of the exposed workers had positive skin reactions to either full-fat or defatted soy bean. None of the controls was SPT-positive, Eight of the exposed workers had increased levels of soy-specific IgE of whom only 4 were SPT-positive and had an increased level of soy-specific IgE. One of the control workers had an increased level of soy-specific IgE. Workers with an increased specific IgE or SPT positive to soy bean did not have more symptoms than workers with negative tests. However, work-related breathlessness was significantly higher in the exposed group (P < 0,05). Conclusions: The data suggest that the immunological tests for sensitisation were not useful in identifying workers with soy bean-related disease but that tests for sensitisation were linked to exposure.S Afr Med J 1995; 85: 522-52

Internal Migration and Regional Population Dynamics in Europe: Estonia Case Study

Estonia has experienced a long-lasting and strong influence of international migration on regional population growth. Post-war immigrants account for about 36 per cent of the total population, and are concentrated in larger cities of Northern Estonia. Regionally, the relative proportions of the native-born and immigrant origin sub-populations are important for the understanding of population change and internal migration flows in the 1980-1990s. In Estonia, the quality of migration data requires careful assessment. The preservation of Soviet-type record-keeping has reduced data quality in the 1990s, already low, and use of the data should keep data quality problems in mind. Otherwise, false conclusions can be reached. To describe internal migration patterns, it has proved technically feasible and very useful to disaggregate the county population into rural and urban components, and correspondingly, the migration flows into four directions (urban-urban, urban-rural, rural-urban and rural-rural). During the 1980s the pattern of population growth and internal migration has changed in Estonia. Reflecting the turnaround in long-term population processes, migration development reached the advanced stage with more or less regionally balanced in- and out-migration flows and decreasing importance of net migration. Accordingly, to understand current trends and patterns, explanations must be sought from the 1980s which has served a starting point for the present trends rather than from the period of economic transition in the 1990s. As a part of the turnaround, the century-long persistent rural depopulation has come to an end and the moderate growth has started reflecting natural population increase as well as deurbanization. In the 1980s two developments have occurred in parallel: migratory increase of rural population led by a deurbanizing native-born population, and continued urban population growth as a result of the population momentum of pre-transition immigrants. In future decades, the urban deconcentration will probably be the underlying trend in Estonia. In Estonia, noticeable proportion of territory and population is located in islands. However, the island population does not show any systematic difference in the type of internal migration. Particularly, the depopulation of island populations, observed in several comparable European cases, is not occurring. Each life-course stage was found to have its specific migration pattern, more stable than the pattern for the total population. In many cases the changes of internal migration are determined by the change in the proportion of population in different life-course stages. Additionally, the life-course approach has been useful in demonstrating the features of the present Estonian internal migration pattern which appear closer to the countries of comparable in demographic development, more or less regardless of the significant differences in the level of economic development. Among life-course groups, in Estonia the older working age population was characterized by the strongest deurbanization intensities in 1995. The same group has also undergone the largest modification of migration pattern during the economic transition (1987-1995)

Hydrophobic organization of membrane proteins

Membrane-exposed residues are more hydrophobic than buried interior residues in the transmembrane regions of the photosynthetic reaction center from Rhodobacter sphaeroides. This hydrophobic organization is opposite to that of water-soluble proteins. The relative polarities of interior and surface residues of membrane and water soluble proteins are not simply reversed, however. The hydrophobicities of interior residues of both membrane and water-soluble proteins are comparable, whereas the bilayer-exposed residues of membrane proteins are more hydrophobic than the interior residues, and the aqueous-exposed residues of water-soluble proteins are more hydrophilic than the interior residues. A method of sequence analysis is described, based on the periodicity of residue replacement in homologous sequences, that extends conclusions derived from the known atomic structure of the reaction center to the more extensive database of putative transmembrane helical sequences

Radiation Front Sweeping the Ambient Medium of Gamma-Ray Bursts

Gamma-ray bursts (GRBs) are emitted by relativistic ejecta from powerful cosmic explosions. Their light curves suggest that the gamma-ray emission occurs at early stages of the ejecta expansion, well before it decelerates in the ambient medium. If so, the launched gamma-ray front must overtake the ejecta and sweep the ambient medium outward. As a result a gap is opened between the ejecta and the medium that surfs the radiation front ahead. Effectively, the ejecta moves in a cavity until it reaches a radius R_{gap}=10^{16}E_{54}^{1/2} cm where E is the isotropic energy of the GRB. At R=R_{gap} the gap is closed, a blast wave forms and collects the medium swept by radiation. Further development of the blast wave is strongly affected by the leading radiation front: the front plays the role of a precursor where the medium is loaded with e+- pairs and preaccelerated just ahead of the blast. It impacts the emission from the blast at R < R_{load}=5R_{gap} (the early afterglow). A spectacular observational effect results: GRB afterglows should start in optical/UV and evolve fast (< min) to a normal X-ray afterglow. The early optical emission observed in GRB 990123 may be explained in this way. The impact of the front is especially strong if the ambient medium is a wind from a massive progenitor of the GRB. In this case three phenomena are predicted: (1) The ejecta decelerates at R<R_{load} producing a lot of soft radiation. (2) The light curve of soft emission peaks at t_{peak}=40(1+z)E_{54}^{1/2}(Gamma_{ej}/100)^{-2} s where Gamma_{ej} is the Lorentz factor of the ejecta. Given measured redshift z and t_{peak}, one finds Gamma_{ej}. (3) The GRB acquires a spectral break at 5 - 50 MeV because harder photons are absorbed by radiation scattered in the wind.Comment: 20 pages, accepted to Ap

Critical review of the impacts of grazing intensity on soil organic carbon storage and other soil quality indicators in extensively managed grasslands

Acknowledgements This work contributes to the N-Circle project (grant number BB/N013484/1), and CINAg (BB/N013468/1) Virtual Joint Centres on Agricultural Nitrogen (funded by the Newton Fund via UK BBSRC/NERC), U-GRASS (grant number NE/M016900/1), the Belmont Forum/FACCE-JPI DEVIL project (grant number NE/M021327/1), Soils-R-GGREAT (grant number NE/P019455/1), ADVENT (grant number NE/M019713/1), Sêr Cymru LCEE-NRN project, Climate-Smart Grass and the Scottish Government’s Strategic Research Programme.Peer reviewedPublisher PD

Some Late-time Asymptotics of General Scalar-Tensor Cosmologies

We study the asymptotic behaviour of isotropic and homogeneous universes in general scalar-tensor gravity theories containing a p=-rho vacuum fluid stress and other sub-dominant matter stresses. It is shown that in order for there to be approach to a de Sitter spacetime at large 4-volumes the coupling function, omega(phi), which defines the scalar-tensor theory, must diverge faster than |phi_infty-phi|^(-1+epsilon) for all epsilon>0 as phi rightarrow phi_infty 0 for large values of the time. Thus, for a given theory, specified by omega(phi), there must exist some phi_infty in (0,infty) such that omega -> infty and omega' / omega^(2+epsilon) -> 0 as phi -> 0 phi_infty in order for cosmological solutions of the theory to approach de Sitter expansion at late times. We also classify the possible asymptotic time variations of the gravitation `constant' G(t) at late times in scalar-tensor theories. We show that (unlike in general relativity) the problem of a profusion of ``Boltzmann brains'' at late cosmological times can be avoided in scalar-tensor theories, including Brans-Dicke theory, in which phi -> infty and omega ~ o(\phi^(1/2)) at asymptotically late times.Comment: 14 page

Negative vacuum energy densities and the causal diamond measure

Arguably a major success of the landscape picture is the prediction of a small, non-zero vacuum energy density. The details of this prediction depends in part on how the diverging spacetime volume of the multiverse is regulated, a question that remains unresolved. One proposal, the causal diamond measure, has demonstrated many phenomenological successes, including predicting a distribution of positive vacuum energy densities in good agreement with observation. In the string landscape, however, the vacuum energy density is expected to take positive and negative values. We find the causal diamond measure gives a poor fit to observation in such a landscape -- in particular, 99.6% of observers in galaxies seemingly just like ours measure a vacuum energy density smaller than we do, most of them measuring it to be negative.Comment: 9 pages, 3 figures; v2: minor error fixed (results essentially unchanged), reference added; v3: published version, includes a few clarification

Nonlinear ion waves in Fermi-Dirac pair plasmas

Arbitrary amplitude nonlinear ion waves is investigated in an extremely degenerate electron-positron-ion plasma with relativistic electrons/positrons and dynamic cold ions using Sagdeev pseudo-potential method in framework of quantum hydrodynamics model. The matching criteria of existence for ion solitary as well as periodic nonlinear excitations is studied numerically in terms of the relativistic degeneracy parameter, relative positron concentration and the relativistic normalized propagation-speed range of these waves are obtained. It is remarked that the electron relativistic degeneracy and relative positron concentration in such plasmas have significant effects on nonlinear wave propagations in relativistically degenerate Fermi-Dirac plasma. Our results are in good agreement with the previously reported ones obtained using semiclassical Thomas-Fermi approximation in dense plasmas with non-relativistic and ultra-relativistic electrons and positrons. Current findings can be appropriate for the study of astrophysical superdense compact objects such as white dwarfs.Comment: Published in Physics of Plasma

Compton Echoes from Gamma-ray Bursts

Recent observations of gamma-ray bursts (GRBs) have provided growing evidence for collimated outflows and emission, and strengthened the connection between GRBs and supernovae. If massive stars are the progenitors of GRBs, the hard photon pulse will propagate in the pre-burst, dense environment. Circumstellar material will Compton scatter the prompt GRB radiation and give rise to a reflection echo. We calculate luminosities, spectra, and light curves of such Compton echoes in a variety of emission geometries and ambient gas distributions, and show that the delayed hard X-ray flash from a pulse propagating into a red supergiant wind could be detectable by Swift out to z~0.2. Independently of the gamma-ray spectrum of the prompt burst, reflection echoes will typically show a high-energy cutoff between m_ec^2/2 and m_ec^2 because of Compton downscattering. At fixed burst energy per steradian, the luminosity of the reflected echo is proportional to the beaming solid angle, Omega_b, of the prompt pulse, while the number of bright echoes detectable in the sky above a fixed limiting flux increases as Omega_b^{1/2}, i.e. it is smaller in the case of more collimated jets. The lack of an X-ray echo at one month delay from the explosion poses severe constraints on the possible existence of a lateral GRB jet in SN 1987A. The late r-band afterglow observed in GRB990123 is fainter than the optical echo expected in a dense red supergiant environment from a isotropic prompt optical flash. Significant MeV delayed emission may be produced through the bulk Compton (or Compton drag) effect resulting from the interaction of the decelerating fireball with the scattered X-ray radiation.Comment: LaTeX, 18 pages, 4 figures, revised version accepted for publication in the Ap