PSEUDOCHOLINESTERASE AS A PREDICTOR MARKER IN HYPOTHYROID PATIENTS

Introduction: Hypothyroidism is due to decreased circulating levels of Thyroid hormones and is caused by inadequate functioning of thyroid gland. Pseudocholinesterase (PCHE) is a nonspecific cholinesterase enzyme that hydrolyses choline based esters in plasma. The purpose of this study was to evaluate the serum level of PCHE in hypothyroid patients. Methodology: The present study was conducted on 100 newly diagnosed hypothyroid patients attending the Medical OPD. The results of patients were compared with 100 healthy controls of either sex of similar age group. Anthropometric measurements, T3, T4, TSH, PCHE & Cholesterol estimations were performed. Results: The mean serum PCHE (decrease) level was observed statistically highly significant (p<0.001) in hypothyroid patients as compared with healthy control subjects. A highly significant positive correlation between PCHE with T3 & T4 (p< 0.001) in hypothyroid cases. Conclusion: Serum Pseudocholinesterase may be helpful as biomarker in screening test  for hypothyroidism along with thyroid stimulating hormone

PSEUDOCHOLINESTERASE AS A PREDICTOR MARKER IN HYPOTHYROID PATIENTS

Introduction: Hypothyroidism is due to decreased circulating levels of Thyroid hormones and is caused by inadequate functioning of thyroid gland. Pseudocholinesterase (PCHE) is a nonspecific cholinesterase enzyme that hydrolyses choline based esters in plasma. The purpose of this study was to evaluate the serum level of PCHE in hypothyroid patients. Methodology: The present study was conducted on 100 newly diagnosed hypothyroid patients attending the Medical OPD. The results of patients were compared with 100 healthy controls of either sex of similar age group. Anthropometric measurements, T3, T4, TSH, PCHE & Cholesterol estimations were performed. Results: The mean serum PCHE (decrease) level was observed statistically highly significant (p<0.001) in hypothyroid patients as compared with healthy control subjects. A highly significant positive correlation between PCHE with T3 & T4 (p< 0.001) in hypothyroid cases. Conclusion: Serum Pseudocholinesterase may be helpful as biomarker in screening test  for hypothyroidism along with thyroid stimulating hormone

Synthesis and antibacterial evaluation of nitrogen containing novel heterocyclic chalcones

<p>Thirteen different novel heterocyclic chalcones were synthesized using cycloaddition and Claisen–Schmidt condensation reactions. These newly synthesized compounds were characterized by their spectral studies and structure of (<i>E</i>)-3-(4-methoxyphenyl)-1-(5-methyl-1-(pyridin-3-yl)-1<i>H</i>-1,2,3-triazol-4-yl)prop-2-en-1-one (<b>4h</b>) was also evidenced by single crystal X-ray studies. These compounds were evaluated for antibacterial activities against seven bacterial strains <i>in vitro</i>. Compounds <b>4b</b> and <b>4c</b> containing 4-fluoro and 4-chloro groups have shown remarkable inhibition as showed by the standard drug ciprofloxacin against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, respectively. Another compound <b>4k</b> containing 3,4,5-trimethoxy group also showed similar activity against both these strains. Beside these three potential compounds <b>4b, 4c, 4k</b>, one more compound <b>4g</b> containing 4-methyl group showed equivalent inhibition as that of standard drug against <i>E. coli.</i> These categories of compounds are therefore good candidates for developing new effective antibacterial in future.</p

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