A Case Study of the Impact of Zero-Based Staffing and the Teacher Selection Process in the Improvement of Academic Success Indicators in an Underachieving Elementary School in Maryland

This case study examined the process of zero-based staffing as a reform model for improving academic achievement at an underachieving elementary school in a county school system in Maryland. The process of zero-based staffing involved the involuntary transfer of all professional staff from the building. This study examined the zero-based process used to restructure the school, the teacher selection process, and the characteristics of the teachers selected for the school. A qualitative design methodology was employed to examine the processes through a naturalistic inquiry approach. Four semistructured interview instruments were utilized to gather data from the superintendent, principal, teachers, and the teacher selection committee. Superintendent, principal, and teacher interviews were conducted in a one-on-one setting. The teacher selection committee was interviewed as a group. The researcher attended a variety of school meetings and visited classrooms as an indweller to gain perspective regarding the school culture. In addition, Maryland State Assessment data was examined to compare student achievement before and after the new teachers were hired for the school. The comparison of Maryland State Assessment data from one year to the next indicated improvement in both reading and math. This improvement was significant enough to remove the school from the state list of failing schools. Results of the study indicated that the use of zero-based staffing as a reform model was effective in facilitating the hiring of teachers with common characteristics and values. Primary characteristics and values of these teachers included the belief that all children can learn and a positive and caring attitude. These attitudes combined with the willingness and expectation to engage in continuous and collaborative learning improved student performance

Modeling U.S. Soy-Based Markets with Directed Acyclic Graphs and Bernanke Structural VAR Methods: The Impacts of High Soy Meal and Soybean Prices

Advanced methods that combine directed acyclic graphs with Bernanke structural vector autoregression models are applied to a monthly system of three U.S. soy-based markets: for soybeans upstream and for the two soybean co-products soy meal and soy oil further downstream. Analyses of the impulse-response function and forecast error variance decompositions provide updated estimates of market-elasticity parameters that drive these markets and updated policy-relevant information on how these monthly markets run and dynamically interact. Results characterize impacts on the three U.S. soy-based markets of increases in U.S. prices of soy meal and soybeans.Industrial Organization,

Devonian Hydrocarbon Production in South Central Kentucky: A GIS Study

Historically, Devonian Corniferous hydrocarbon production in south-central Kentucky has been a major contributor to the total hydrocarbon resources within Butler, Edmonson, and Warren counties. The Corniferous adds to the already large hydrocarbon totals produced from the Illinois Basin; however, this hydrocarbon contribution does not come without major pitfalls and inconsistencies. The south-central Kentucky Devonian Corniferous rocks comprise a diverse and complex hydrocarbon system made up of multiple migration pathways, trapping mechanisms, and seals. The multiple Corniferous units all derive production from the same source rock: the New Albany Shale. A Geographic Information System (GIS) containing data on surface elevations, structure contours and faults, geophysical well logs, well-scale oil and gas production, and lease to regional-scale oil and gas production has been compiled to produce a threedimensional (3-D) model using kriging with barriers to explain spatially the complexities of the Devonian Corniferous in south-central Kentucky. This model identifies the potential source rocks, the hydrocarbon charging and migration pathways, reservoirs, and reservoir seals. This model also utilizes kernel density estimation for developing an understanding of the spatial relationship of stratigraphic units being targeted within the Devonian relative to the spatially modeled Devonian Corniferous structures. This model also indicates locations and depths of key producing zones within south-central Kentucky. This project also explains the potential reasoning leading to the development of the Devonian Corniferous as a major hydrocarbon resource by placing it in the context of the underlying Silurian Corniferous and the multiple Siluro-Devonian unconformities positioned throughout the entire Siluro-Devonian section. This project bridges the gap between: 1) potential buried Silurian-age reef systems located south of the Pennyrile Fault zone, 2) the pervasive high porosity sections found in the lower Clear Creek Limestone unit, and 3) the development of expansive secondary partial dolomitization related to unconformable surfaces in the Middle and Upper Devonian Corniferous

High Resolution Mapping of Enhancer-Promoter Interactions

RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for analyzing ChIA-PET data, the ChIA-PET Tool, discovers interaction anchors at a spatial resolution that is insufficient to accurately identify individual enhancers. We introduce Germ, a computational method that estimates the likelihood that any two narrowly defined genomic locations are jointly occupied by RNA Polymerase II. Germ takes a blind deconvolution approach to simultaneously estimate the likelihood of RNA Polymerase II occupation as well as a model of the arrangement of read alignments relative to locations occupied by RNA Polymerase II. Both types of information are utilized to estimate the likelihood that RNA Polymerase II jointly occupies any two genomic locations. We apply Germ to RNA Polymerase II ChIA-PET data from embryonic stem cells to identify the genomic locations that are jointly occupied along with transcription start sites. We show that these genomic locations align more closely with features of active enhancers measured by ChIP-Seq than the locations identified using the ChIA-PET Tool. We also apply Germ to RNA Polymerase II ChIA-PET data from motor neuron progenitors. Based on the Germ results, we observe that a combination of cell type specific and cell type independent regulatory interactions are utilized by cells to regulate gene expression.National Institutes of Health (U.S.) (Grant 1U01HG007037

Prequtaneous transluminal angioplasty in patients with multivessel coronary disease: How important is complete revascularization for cardiac event-free survival?

AbstractThe relative influences of revascularizationstaus and baseline characteristics on long-term outcome were examined in 867 patients with multivessel coronarydisease who had undergone successful coronary angioplasty. These patients represented 83% of a total of 1,039 patients in whom angioplasty had been attempted with an in-hospltal mortality and infarction rate of 2.5% and 48%, respectively. Emergency coronary bypass surgery was needed in 4.9%. Of the 867 patients, 41% (group 1) were considered to have complete revascularization and 59% (group 2) to have incomplete revascularization. Univariate analysis revealed major differences between these two groups with patients in group 2 characterized by advanced age, more severe angina, a greater likelihood of previous coronary surgery and infarction, more extensive disease and poorer left ventricular function.Over a mean follow-up period of 26 months, the probability of event-free survival was significantly lower for group 2 only with respect to the need for coronary artery surgery (p = 0.004) and occurrence of severe angina (p = 0.04). The difference in modality was of borderline significance (p = 0.051) and there were no signiicant difference between 1 and 2 in either the incidence of myocardial infarction or the need for repeat angioplasty.Muitivariate analysis identified independent baseline predictors of late cardiac events that were then used to adjust the probabilities of event-free survival. This adjustment effectively removed any significant influence of completeness of revascuiarization on event-free survival for any of the above end points including the combination of death, myocardial infarction and need for coronary artery surgery. Therefore, late outcome in these patients is not significantly influenced by revascularization status but depends more on baseline patient characteristics

Flapping Wing Micro Air Vehicle Bench Test Setup

The purpose of this research was to develop testing methods that can be used to determine the forces, moments, and deflections involved in flapping wing aerodynamics. To pursue the research, a flapping wing mechanism and wings with spans ranging from 9.1 inches to 12.1 inches were built. A variety of mechanisms, capable of, alternatively, purely flapping, flapping with pitch, and flapping with pitch and out-of-plane motion were conceptualized and drawn using solid modeling software. Two of the simpler designs, a single degree-of-freedom flapping mechanism and the two-degree of freedom flapping mechanism were fabricated using a rapid prototype 3-D printer, and sustained operation was demonstrated. A thrust stand and a six-component force balance were used to gather force data from the flapping-only mechanism, combined with a variety of wing shapes. Four high-speed cameras were used to capture the motion of the wings. To minimize intrusiveness an array of laser dots was projected onto the wing during flapping and photogrammetry software was used to analyze the images and determine a shape profile of the wing composed of a frame and membrane during flapping. While the focus of this research was on the bench test setup development, some insight into the influence of wing design on the forces acting on the mechanism was gained

923-6 Intravenous Adenosine and Lidocaine to Limit Reperfusion Injury During Acute Myocardial Infarction: Preliminary Data

Adenosine (ADO) and lidocaine (LDO) given prior to restoration of blood flow reduces reperfusion injury in animals. We conducted a pilot study of intravenous ADO and LDO in pts undergoing direct angioplasty for acute myocardial infarction (AMI). Pts with ≤12 hours of chest pain and electrocardiographic evidence of AMI were given LDO 1mg/kg iv bolus and 2mg/min iv infusion beginning at the time of recruitment, and ADO 70mcg/kg iv infusion beginning when coronary occlusion (TIMI grade 0–1 blood flow) was confirmed angiographically. Pts with bronchospasm, blood pressure <100mmHg, or<1° heart block were excluded. ADO and LDO were given for 1 hour after vessel patency was restored. Myocardial area at risk and final infarction area were measured with serial Tc-99m-sestamibi perfusion studies (prior to angioplasty, before hospital discharge and 6 weeks after discharge). A salvage index (S1) was constructed by correcting the change in sestamibi perfusion defect for the mass of myocardium at risk. Analysis of 25 patients completing the protocol revealed a mean (±SD) salvage of 20±17% and S1=0.55. Salvage and S1 were 25±18% and 0.54 for anterior infarctions, 13±5% and 0.57 for inferior infarctions, respectively. These data were compared to an historical control group consisting of 50 patients undergoing direct angioplasty for AMI without adjunctive ADO/LDO. After adjustment for time to treatment and perfusion nadir, analysis of covariance revealed a similar degree of early salvage in the study and control groups (p=0.3). However, at 6 weeks, the median infarct size for study pts was 0. Using logistic regression analysis, significantly more study pts had no final measureable infarction at 6 weeks than control pts at hospital discharge (p=0.007). After adjusting for infarct size, location and time to treatment, this difference persisted (p=0.04).ConclusionsAdjunctive ADO and LDO during angioplasty for AMI may favorably affect late final infarction size. Randomized studies assessing 6 week final infarction size are needed

Intravascular ultrasound imaging: In vitro validation and pathologic correlation

AbstractIntravascuiar ultrasound imaging is a new method in which high resolution images of the arterial wall are obtained with use of a catheter placed within an artery. An in vitro Plexiglas well model was used to validate measurements of the luminal area, and an excellent correlation was obtained. One hundred thirty segments of fresh peripheral arteries underwent ultrasound imaging and the findings were compared with the corresponding histopathologic sections. luminal areas determined with ultrasound imaging correlated well with those calculated from microscopic slides (r = 0.98).Three patterns were identified on the ultrasound images: 1) distinct interface between media and adventitia, 2) indistinct interface between media and adventitia but different echo density layers, and 3) diffuse homogeneous appearance. The types of patterns depended on the relative composition of the and adventitia. Calcification of intimal plaque obscured underlying structures. Atherosclerotic plaque was readily visualized but could not always be differentiated from the underlying media

Genetically engineered probiotic E. coli Nissle to consume amino acids associated with orphan metabolic diseases

Orphan metabolic diseases are rare genetic defects that interfere with metabolism due to ineffective or missing enzymes. Two of them, Phenylketonuria (PKU) and Maple Syrup Urine Disease (MSUD) are defined by accumulation of amino acids to toxic levels due to defective metabolism of protein break down products. PKU is caused by a defect in the gene encoding phenylalanine hydroxylase (PAH). MSUD is caused by a defect in a multi-enzyme complex found in mitochondria called branched chain ɑ-ketoacid dehydrogenase “BCKDH”. Without the activity of these enzymes, the amino acid phenylalanine (Phe) in the case of PKU or the branched-chain amino acids leucine (Leu), isoleucine and valine for MSUD build up to neurotoxic levels in the blood and brain, leading to neurological deficits. Current treatment options focus on dietary protein restriction, are insufficient and, unfortunately, can lead to a failure to thrive. Lifelong compliance with a prescription diet is also a concern. We have genetically engineered Nissle, a probiotic strain of E. coli, to reduce serum phenylalanine and leucine levels in patients with PKU or MSUD; preclinical data supporting the activity of these strains are described. Please click Additional Files below to see the full abstract