Allergies Related to Mosquitoes, Repellents, and Insecticides

Man\u27s skin response to the mosquito bite exhibits great individual variability. The everyday immediate reaction consists o f a red, or erythematous wheal that lasts only one or two hours. Twenty to 24 hours after the mosquito bite, a delayed reaction of erythema, swelling, and itching may also occur. An individual may exhibit an immediate reaction, delayed reaction, both reactions, or neither reaction. Studies suggest that sensitization to mosquito saliva may be responsible for the inflammatory response. This hypothesis is supported by histologic studies which demonstrate striking infiltration of inflammatory cells at the site of mosquito bites. Severe local reactions can occur in areas of compromised circulation. Severe systemic reactions, on the other hand, are extremely rare. Although allergy or hypersensitivity to mosquito saliva is thought to cause both the ordinary and systemic bite reactions, this has not been investigated by modern immunologic methods. The use of insect repellents is a safe, effective method for avoiding insect bites. However, these agents can cause allergic contact dermatitis or hives. Aerosol insecticides are also effective, but respiratory allergic symptoms can occur in susceptible or asthmatic individuals

Decision-making Techniques for Community Groups

Community groups often have a problem coming to a decision about projects to undertake. Quite often, resources, both human and financial, are limited; the number of problems seem overwhelming; or there are forceful advocates of a "pet" project. How can a group overcome these difficulties? The four decision-making techniques shown in this guide will make the task easier. The first two techniques generate ideas about community goals or projects while the last two prioritize the alternatives you have identified.New 6/92/5M

Town Meetings that Work

Town meetings -- The nature of community -- Orgainizing a town meeting -- The town meeting process -- Final thoughts -- AppendiciesNew 4/93/lM.Includes bibliographical reference

Decision-making techniques for community groups

"Community groups often have a problem coming to a decision about projects to undertake. Quite often, resources, both human and financial, are limited; the number of problems seem overwhelming; or there are forceful advocates of a 'pet' project. How can a group overcome these difficulties? The four decision-making techniques shown in this guide will make the task easier. The first two techniques generate ideas about community goals or projects, while the last two prioritize the alternatives you have identified."--Page 1.Reviewed by Sarah Hultine Massengale (Community Economic Development). Johanna Reed Adams, Charles M. St. Clair and William E. Robertson (Department of Community Development)Reviewed 03/202

The Lantern Vol. 17, No. 3, Summer 1949

• All the Silver in Taxco • The Fall • Parlor Games • Something There Is • Friday Night • Evening • Checker-Board Country • A Noise • Expected Up In Heaven Today • When Time Has Torn My Youth • Impression of Deathhttps://digitalcommons.ursinus.edu/lantern/1048/thumbnail.jp

Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation

Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor histocompatibility antigens (mHA). The mHA presented on the HLA class I and II molecules and the ensuing T cell response to these antigens results in graft vs. host disease. In this paper, results of a whole exome sequencing study are presented, with resulting alloreactive polymorphic peptides and their HLA class I and HLA class II (DRB1) binding affinity quantified. Large libraries of potentially alloreactive recipient peptides binding both sets of molecules were identified, with HLA-DRB1 generally presenting a greater number of peptides. These results are used to develop a quantitative framework to understand the immunobiology of transplantation. A tensor-based approach is used to derive the equations needed to determine the alloreactive donor T cell response from the mHA-HLA binding affinity and protein expression data. This approach may be used in future studies to simulate the magnitude of expected donor T cell response and determine the risk for alloreactive complications in HLA matched or mismatched hematopoietic cell and solid organ transplantation

Anderson Localization, Non-linearity and Stable Genetic Diversity

In many models of genotypic evolution, the vector of genotype populations satisfies a system of linear ordinary differential equations. This system of equations models a competition between differential replication rates (fitness) and mutation. Mutation operates as a generalized diffusion process on genotype space. In the large time asymptotics, the replication term tends to produce a single dominant quasispecies, unless the mutation rate is too high, in which case the populations of different genotypes becomes de-localized. We introduce a more macroscopic picture of genotypic evolution wherein a random replication term in the linear model displays features analogous to Anderson localization. When coupled with non-linearities that limit the population of any given genotype, we obtain a model whose large time asymptotics display stable genotypic diversityComment: 25 pages, 8 Figure

Exercise training increases glucose transporter protein GLUT-4 in skeletal muscle of obese Zucker (fa/fa) rats

AbstractThe present study examined the level of GLUT-4 glucose transporter protein in gastrocnemius muscles of 36 week old genetically obese Zucker (fa/fa) rats and their lean (Fa/-) littermates, and in obese Zucker rats following 18 or 30 weeks of treadmill exercise training. Despite skeletal muscle insulin resistance, the level of GLUT-4 glucose transporter protein was similar in lean and obese Zucker rats. In contrast, exercise training increased GLUT-4 protein levels by 1.7 and 2.3 fold above sedentary obese rats. These findings suggest endurance training stimulates expression of skeletal muscle GLUT-4 protein which may be responsible for the previously observed increase in insulin sensitivity with training