Superconducting RF Technology R&D for Future Accelerator Applications

Superconducting rf technology (SRF) is evolving rapidly as are its applications. While there is active exploitation of what one may term the current state-of-the-practice, there is also rapid progress expanding in several dimensions the accessible and useful parameter space. While state-of-the-art performance sometimes outpaces thorough understanding, the improving scientific understanding from active SRF research is clarifying routes to obtain optimum performance from present materials and opening avenues beyond the standard bulk niobium. The improving technical basis understanding is enabling process engineering to both improve performance confidence and reliability and also unit implementation costs. Increasing confidence in the technology enables the engineering of new creative application designs. We attempt to survey this landscape to highlight the potential for future accelerator applications.Comment: Submitted to Reviews of Accelerator Science and Technolog

Experimental Observation of Modulation Instability and Optical Spatial Soliton Arrays in Soft Condensed Matter

In this Letter we report observations of optically induced self-organization of colloidal arrays in the presence of un-patterned counter-propagating evanescent waves. The colloidal arrays formed along the laser propagation-axis are shown to be linked to the break-up of the incident field into optical spatial solitons, the lateral spacing of the arrays being related to modulation instability of the soft condensed matter system.Comment: 16 pages, 3 figure

Superconducting Surface Impedance under Radiofrequency Field

Based on BCS theory with moving Cooper pairs, the electron states distribution at 0K and the probability of electron occupation with finite temperature have been derived and applied to anomalous skin effect theory to obtain the surface impedance of a superconductor under radiofrequency (RF) field. We present the numerical results for Nb and compare these with representative RF field-dependent effective surface resistance measurements from a 1.5 GHz resonant structure

Operating Experience with Superconducting Cavities at Jefferson Lab

The CEBAF recirculating superconducting electron linac at Jefferson Lab is now in full operation supporting nuclear physics experiments in three target halls at up to 4.4 GeV. The 330 SRF cavities, operating at 2.0 K, continue to perform well above design specifications, and have accumulated over 8,000,000 operating cavity hours. The authors have to date no evidence of degradation of cavity performance. The SRF cavities have demonstrated excellent reliability. The one klystron per cavity design provides CEBAF with flexibility and redundancy for normal operations. Several techniques have been developed for establishing optimum operating conditions for the 330 independent systems. Operation of the cavities and control systems at the full design current of 1 mA has recently been achieved. The principal constraints on usable gradient for low current operations are (1) discharge at the cold ceramic rf window induced by electron field emission in cavities, (2) tuner controls, and (3) stability of the waveguide vacuum in the region between the warm and cold windows. Several cryomodules have been improved by application of rf helium processing while installed on the beamline

Continuous wave superconducting radio frequency electron linac for nuclear physics research

CEBAF, the Continuous Electron Beam Accelerator Facility, has been actively serving the nuclear physics research community as a unique forefront international resource since 1995. This CW electron linear accelerator (linac) at the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility (Jefferson Lab) has continued to evolve as a precision tool for discerning the structure and dynamics within nuclei. Superconducting RF (SRF) technology has been the essential foundation for CEBAF, first as a 4 GeV machine, then 6 GeV, and currently capable of 12 GeV. We review the development, implementation, and performance of SRF systems for CEBAF from its early beginnings to the commissioning of the 12 GeV era.Comment: 56 pages, 31 figures, accepted for publication in Physical Review Accelerators and Beam

Investigating the evolution of apoptosis in malaria parasites: the importance of ecology

Apoptosis is a precisely regulated process of cell death which occurs widely in multicellular organisms and is essential for normal development and immune defences. In recent years, interest has grown in the occurrence of apoptosis in unicellular organisms. In particular, as apoptosis has been reported in a wide range of species, including protozoan malaria parasites and trypanosomes, it may provide a novel target for intervention. However, it is important to understand when and why parasites employ an apoptosis strategy before the likely long-and short-term success of such an intervention can be evaluated. The occurrence of apoptosis in unicellular parasites provides a challenge for evolutionary theory to explain as organisms are expected to have evolved to maximise their own proliferation, not death. One possible explanation is that protozoan parasites undergo apoptosis in order to gain a group benefit from controlling their density as this prevents premature vector mortality. However, experimental manipulations to examine the ultimate causes behind apoptosis in parasites are lacking. In this review, we focus on malaria parasites to outline how an evolutionary framework can help make predictions about the ecological circumstances under which apoptosis could evolve. We then highlight the ecological considerations that should be taken into account when designing evolutionary experiments involving markers of cell death, and we call for collaboration between researchers in different fields to identify and develop appropriate markers in reference to parasite ecology and to resolve debates on terminology.Host-parasite interactio

Plasticity in transmission strategies of the malaria parasite, Plasmodium chabaudi : environmental and genetic effects

Parasites may alter their behaviour to cope with changes in the within-host environment. In particular, investment in transmission may alter in response to the availability of parasite resources or host immune responses. However, experimental and theoretical studies have drawn conflicting conclusions regarding parasites' optimal (adaptive) responses to deterioration in habitat quality. We analyse data from acute infections with six genotypes of the rodent malaria species to quantify how investment in transmission (gametocytes) is influenced by the within-host environment. Using a minimum of modelling assumptions, we find that proportional investment in gametocytogenesis increases sharply with host anaemia and also increases at low parasite densities. Further, stronger dependence of investment on parasite density is associated with greater virulence of the parasite genotype. Our study provides a robust quantitative framework for studying parasites' responses to the host environment and whether these responses are adaptive, which is crucial for predicting the short-term and evolutionary impact of transmission-blocking treatments for parasitic diseases