Odontogenic Fibromyxoma of Maxilla: A Case Report

Odontogenic fibromyxoma (OM) is a rare locally invasive, non metastasizing benign neoplasm found exclusively in the jaws. It commonly occurs in the second and third decade,and the mandible is involved more commonly than the maxilla. The lesion often grows without symptoms and presents as a painless swelling. The radiographic features are variable so the diagnosis is not easy in many cases. It posesa diagnostic and therapeutic challenge due to its morphology and biological behaviour. A caseo f OM of the maxilla with unusual radiographic and histological features is described in a 27 year old female

A novel technique of using implant drills for decompression of large cystic lesions

Many techniques and materials have been used in the past for decompression of large cysts, but proper description of technique had not been specified,here we enumerate technique of using implant drills for creating a bony window transmucosally and usage of Pediatric ET tube for decompression

Non Syndromic Bilateral Dentigerous Cysts: An Unusual Case Report

Dentigerous cysts are odontogenic developmental cyst, which mostly surround the crown of unerupted teeth, odontomas, or supernumerary teeth. These cyst are mostly solitary in occurrence, their bilateral presentation is rare, especially in the absence of syndromes like Monteaux-Lamy, Basal cell nevus or Cleidocranial dysplasia. Non syndromic bilateral cysts show a predilection for the mandibular first molar area. We present a unusual case of a 11-year-old girl presenting with bilateral radiolucencies in associated with unerupted mandibular second premolars that were diagnosed histopathologically as dentigerous cysts

Effect of Post Weld Heat Treatments on the Elevated Temperature Mechanical Properties of Ti6Al4V Friction Welds

The {\alpha}+\b {eta} titanium alloy (Ti6Al4V) has been successfully joined using rotary friction welding. To investigate the influence of post weld heat treatments on the microstructure and mechanical properties of the welds, the weld joints were heat treated in {\alpha}+\b {eta} and\b {eta} regions, followed by air cooling and furnace cooling. Subsequent to heat treatment, the specimens were subjected to stress relieving treatment. The heat treatment temperatures were selected keeping in view the beta transus temperature of the alloy. Mechanical properties of the welds are evaluated in the as-welded and post weld heat treated conditions at the working temperature of this alloy. The results reported are an average of the values obtained from three tests carried out at a given set of condition. Joints produced exhibited better mechanical properties when compared to the parent metal. Coarse transgranular microstructure and coarse grains in general exhibit better creep and stress rupture properties, while finer microstructures exhibit better tensile strengthsThe {\alpha}+\b {eta} titanium alloy (Ti6Al4V) has been successfully joined using rotary friction welding. To investigate the influence of post weld heat treatments on the microstructure and mechanical properties of the welds, the weld joints were heat treated in {\alpha}+\b {eta} and\b {eta} regions, followed by air cooling and furnace cooling. Subsequent to heat treatment, the specimens were subjected to stress relieving treatment. The heat treatment temperatures were selected keeping in view the beta transus temperature of the alloy. Mechanical properties of the welds are evaluated in the as-welded and post weld heat treated conditions at the working temperature of this alloy. The results reported are an average of the values obtained from three tests carried out at a given set of condition. Joints produced exhibited better mechanical properties when compared to the parent metal. Coarse transgranular microstructure and coarse grains in general exhibit better creep and stress rupture properties, while finer microstructures exhibit better tensile strength

Validation of Potential Fishing Zone (PFZ) Advisories (2006 – 2007)

The Potential Fishing Zone (PFZ) Advisories are being generated and disseminated by Indian National Centre for Ocean Information Services (INCOIS). The methodology used for generation of these advisories and the scientific basis behind the identification of the PFZ locations was described. With a view to validate these PFZ Advisories and to assess the potential benefits to the fishing community, INCOIS had undertaken PFZ validation experiments at various places under the leadership of fishery experts. Simultaneous fishing operations have been conducted within the PFZ Areas and outside PFZ Areas using identical vessels. The quantitative results of the experiments were described

Socio-economic patterning of cardiometabolic risk factors in rural and peri-urban India: Andhra Pradesh children and parents study (APCAPS).

AIM: To assess the prevalence of cardiometabolic risk factors by socio-economic position (SEP) in rural and peri-urban Indian population. SUBJECTS AND METHODS: Cross-sectional survey of 3,948 adults (1,154 households) from Telangana (2010-2012) was conducted to collect questionnaire-based data, physical measurements and fasting blood samples. We compared the prevalence of risk factors and their clustering by SEP adjusting for age using the Mantel Hansel test. RESULTS: Men and women with no education had higher prevalence of increased waist circumference (men: 8 vs. 6.4 %, P < 0.001; women: 20.9 vs. 12.0 %, P = 0.01), waist-hip ratio (men: 46.5 vs. 25.8 %, P = 0.003; women: 58.8 vs. 29.2 %, P = 0.04) and regular alcohol intake (61.7 vs. 32.5 %, P < 0.001; women: 25.7 vs. 3.8 %, P < 0.001) than educated participants. Unskilled participants had higher prevalence of regular alcohol intake (men: 57.7 vs. 38.7 %, P = 0.001; women: 28.3 vs. 7.3 %, P < 0.001). In contrast, participants with a higher standard of living index had higher prevalence of diabetes (top third vs. bottom third: men 5.2 vs. 3.5 %, P = 0.004; women 5.5 vs. 2.4 %, P = 0.003), hyperinsulinemia (men 29.5 vs. 16.3 %, P = 0.002; women 31.1 vs. 14.3 %, P < 0.001), obesity (men 23.3 vs. 10.6 %, P < 0.001; women 25.9 vs. 12.8 %, P < 0.001), and raised LDL (men 16.8 vs. 11.4 %, P = 0.001; women 21.3 vs. 14.0 %, P < 0.001). CONCLUSIONS: Cardiometabolic risk factors are common in rural India but do not show a consistent association with SEP except for higher prevalence of smoking and regular alcohol intake in lower SEP group. Strategies to address the growing burden of cardiometabolic diseases in urbanizing rural India should be assessed for their potential impact on social inequalities in health

Cohort profile: Andhra Pradesh Children and Parents Study (APCAPS).

The Andhra Pradesh Children and Parents Study (APCAPS) was originally established to study the long-term effects of early-life undernutrition on risk of cardiovascular disease. Its aims were subsequently expanded to include trans-generational influences of other environmental and genetic factors on chronic diseases in rural India. It builds on the Hyderabad Nutrition Trial (HNT) conducted in 1987-90 to compare the effects on birthweight of a protein-calorie supplement for pregnant women and children. The index children of HNT and their mothers were retraced and examined in 2003-05, and the children re-examined as young adults aged 18-21 years in 2009-10. The cohort was expanded to include both parents and siblings of the index children in a recently completed follow-up conducted in 2010-12 (N=∼6225 out of 10,213 participants). Recruitment of the remaining residents of these 29 villages (N=∼55,000) in Ranga Reddy district of Andhra Pradesh is now under way. Extensive data on socio-demographic, lifestyle, medical, anthropometric, physiological, vascular and body composition measures, DNA, stored plasma, and assays of lipids and inflammatory markers on APCAPS participants are available. Details of how to access these data are available from the corresponding author

Diphyllobothriasis in a nine-year-old child in India: a case report

<p>Abstract</p> <p>Introduction</p> <p>The <it>Diphyllobothrium </it>genus belongs to the <it>Diphyllobothridea </it>order of tapeworms. <it>Diphyllobothrium </it>spp., which is commonly known as fish tapeworm, is generally transmitted in humans, but also in other species, such as bears, dogs, cats, foxes, and other terrestrial carnivores. Although worldwide in distribution, the original heartland of <it>Diphyllobothrium </it>spp. spreads across Scandinavia, northern Russia, and western Serbia. We report a rare case that occurred in India.</p> <p>Case presentation</p> <p>A nine-year-old south Indian girl was brought to the casualty at the Prathima Institute of Medical Sciences with complaints of vomiting and loose stools that had started three days earlier. The vomit did not have a foul smell and contained no blood or mucus, but it did contain undigested food particles. The patient described a history of recurrent abdominal pain. She was a non-vegetarian and said she had a history of eating fish.</p> <p>Conclusion</p> <p>The incidence of <it>Diphyllobothrium </it>spp. infection is infrequent in India. Since this is only the fourth reported case in India, and since the previously reported cases also involved observed pediatric patients, we emphasize the need for clinical microbiologists and pediatricians to suspect fish tapeworm infection and recommend epidemiological study of <it>Diphyllobothrium </it>spp. infection.</p

1α,25(OH)2-3-Epi-Vitamin D3, a Natural Physiological Metabolite of Vitamin D3: Its Synthesis, Biological Activity and Crystal Structure with Its Receptor

Background: The 1 alpha,25-dihydroxy-3-epi-vitamin-D(3) (1 alpha,25(OH)(2)-3-epi-D(3)), a natural metabolite of the seco-steroid vitamin D(3), exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcription regulator. In vivo action of 1 alpha,25(OH)(2)-3-epi-D(3) is tissue-specific and exhibits lowest calcemic effect compared to that induced by 1 alpha,25(OH)(2)D(3). To further unveil the structural mechanism and structure-activity relationships of 1 alpha,25(OH)(2)-3-epi-D3 and its receptor complex, we characterized some of its in vitro biological properties and solved its crystal structure complexed with human VDR ligand-binding domain (LBD). Methodology/Principal Findings: In the present study, we report the more effective synthesis with fewer steps that provides higher yield of the 3-epimer of the 1 alpha,25(OH)(2)D(3). We solved the crystal structure of its complex with the human VDR-LBD and found that this natural metabolite displays specific adaptation of the ligand-binding pocket, as the 3-epimer maintains the number of hydrogen bonds by an alternative water-mediated interaction to compensate the abolished interaction with Ser278. In addition, the biological activity of the 1 alpha,25(OH)(2)-3-epi-D(3) in primary human keratinocytes and biochemical properties are comparable to 1 alpha,25(OH)(2)D(3). Conclusions/Significance: The physiological role of this pathway as the specific biological action of the 3-epimer remains unclear. However, its high metabolic stability together with its significant biologic activity makes this natural metabolite an interesting ligand for clinical applications. Our new findings contribute to a better understanding at molecular level how natural metabolites of 1 alpha,25(OH)(2)D(3) lead to significant activity in biological systems and we conclude that the C3-epimerization pathway produces an active metabolite with similar biochemical and biological properties to those of the 1 alpha,25(OH)(2)D(3)