A convenient procedure for the synthesis of phthalimides under microwave irradiation

882-884An efficient, extremely fast and clean procedure for the synthesis of phthalimides 2 and 3 by the reaction of phthalic anhydrides 1 with urea and aromatic amines in the presence of catalytic amount of DMF under microwave irradiation is described. The products are obtained in quantitative yields and excellent purities

Solvent-free microwave enhanced synthesis of 2- arylidene-1-tetralones

1535-1536A rapid and efficient method for the synthesis of 2-arylidene-1-tetralones 2 by the condensation of 1-tetralone 1 with aromatic aldehydes in the presence of p-toluenesulphonic acid (PTSA) in solvent free conditions under microwave irradiation is reported

Luciferase Activity of Insect Fatty Acyl-CoA Synthetases with Synthetic Luciferins

Long-chain fatty acyl-CoA synthetases (ACSLs) are homologues of firefly luciferase but are incapable of emitting light with firefly luciferin. Recently, we found that an ACSL from the fruit fly <i>Drosophila melanogaster</i> is a latent luciferase that will emit light with the synthetic luciferin CycLuc2. Here, we have profiled a panel of three insect ACSLs with a palette of >20 luciferin analogues. An ACSL from the nonluminescent beetle <i>Agrypnus binodulus</i> (AbLL) was found to be a second latent luciferase with distinct substrate specificity. Several rigid luciferins emit light with both ACSLs, but styryl luciferin analogues are light-emitting substrates only for AbLL. On the other hand, an ACSL from the luminescent beetle <i>Pyrophorus angustus</i> lacks luciferase activity with all tested analogues, despite its higher homology to beetle luciferases. Further study of ACSLs is expected to shed light on the features necessary for bioluminescence and substrate selectivity