STUDIES ON APPLICATION OF PROSOLVE AS A DIRECT COMPRESSIBLE VEHICLE FOR IMPROVING THE DISSOLUTION RATE OF POORLY SOLUBLE DRUGS

Prosolve, a new directly compressible vehicle consists of microcrystalline cellulose (98%) and colloidal silicon dioxide (2%). Piroxicam (20 mg) tablets, celecoxib (100 mg) tablets and aceclofenac (100 mg) tablets were formulated employing prosolve and three super disintegrants namely pregelatinised starch, sodium starch glycolate and croscarmellose sodium by direct compression method with a view to enhance their dissolution rate. In the micromeritic evaluation microcrystalline cellulose and its blends with other tablet ingredients exhibited excellent to good flow needed for direct compression. All the tablets formulated employing prosolve fulfilled the Pharmacopoeial standards with regard to various tablet characters. These tablets also gave 2 to 5 fold increase in the dissolution rate when compared to commercial tablets. Among the three disintegrants sodium starch glycolate gave higher dissolution rates when compared with both pregelatinised starch and croscarmellose sodium

SYSTEMS AND METHODS TO OPTIMIZE THE SIGNALING BETWEEN UPF AND SMF DURING HANDOFF AND EPS-INTERNETWORKING

Systems and methods are described herein for optimizing the signaling between a User Plane Function (UPF) and a Session Management Function (SMF) during Handoff (HO) and Evolved Packet System (EPS)-Interworking cases. The systems and methods may be employed to intimate End-Marker notification from a UPF to a Source Radio Access Network (Source-RAN) of a respective 4G/5G Access-Network. This is achieved by introducing Send End Marker Packets (SNDEM) flags in Remove FAR as part of an N4 Session Modification Request. The solution described herein is applicable where a SMF has selected the same or different UPF to interact with a target RAN (T-RAN) based on slice information provided by Network Slice Selection Function (NSSF)

Comparing the personal oral hygiene practices among Government and Private school children of Mahabubnagar, Telangana state - A cross sectional study

Introduction: Oral health is fundamental to general health and well-being. A healthy mouth enables an individual to talk, eat, and socialize without experiencing active disease, discomfort, or embarrassment. Objectives: To assess the knowledge and oral hygiene practices of school children from both Government and Private schools in Mahabubnagar district. Materials and Methods: A total of 150 children aged 11–15 years were randomly selected from six Private and six Government schools. A questionnaire related to their personal and oral hygiene practices was distributed to the school children. Results: The results of this study showed thatmost respondents had a good knowledge of basic hygiene measures and positive attitude towards oral hygiene. The students of both schools exhibited poor oral hygiene practices but were significantly reported more in the Government school than in the Private schools (p<0.005). Majority of the respondents (91.3%) used a commercial toothbrush and toothpaste and half of them (50%) reported brushing twice a day. Two-third of the respondents (75%), had never visited a dental clinic. Conclusion: The results of the present study showed that the knowledge and oral hygiene practices of Government school children were less satisfactory in someaspects when compared to private school children.&nbsp

AUTOMATIC SYMMETRIC NETWORK ADDRESS TRANSLATION DISCOVERY AND TRAVERSE BETWEEN SOFTWARE-DEFINED WIDE AREA NETWORK EDGE DEVICES

The techniques presented herein relate to automatic network address translation (NAT) discovery and traverse for edge devices in a software-defined network in a wide area network (SD-WAN). More specifically, the techniques presented herein relate to techniques for automatic, symmetric NAT discovery and traverse between SD-WAN edge devices that ensure new branches can become part of an SD-WAN overlay network without explicit user (e.g., customer/administrator) involvement. Accordingly, and advantageously, the techniques presented herein can dynamically provide NAT-T hub connectivity for symmetric devices that can be used for service insertion of NAT-T functions. These techniques may vastly simplify SD-WAN deployment in diverse deployments and, thus, may provide significant business value

Inter-rater and intra-rater agreement in causality assessment of adverse drug reactions: a comparative study of WHO-UMC versus Naranjo scale

Background: The causality assessment system proposed by the WHO collaborating centre for international drug monitoring, the Uppsala monitoring centre (WHO-UMC) and the Naranjo probability scale are the generally accepted and most widely used methods for causality assessment. Both these scales are structured, transparent, consistent, and easy to apply with distinct advantages. The PvPI recommends use of WHO-UMC scale while many clinicians prefer Naranjo scale for its simplicity. As both these scales are used very widely in practise, it is important to study the level of agreement among them, to ensure proper interpretation of the causality assessment of the drugs. Objective was to study the inter-rater and intra-rater agreement in causality assessment of adverse drug reactions between WHO-UMC and Naranjo scale.Methods: A total of 200 cases were analyzed by three raters. Each ADR reporting form was analyzed by the raters independently using both the Naranjo scale and the WHO-UMC scale. The inter-rater and Intra-rater agreement of all the three raters was analyzed using kappa statistics.Results: The most common category of causality assessment was ‘possible’ which was around 73%, while the probable, definite and unlikely accounted for 23%, 3% and 1% respectively. The inter-rater agreement for the various categories of causality assessment when using Naranjo scale ranged from “very good to excellent” (Kappa value 0.95) while the same ranged from “good to very good” when the WHO-UMC scale was used (Kappa value 0.89) while the Intra-rater agreement for the three raters ranged from good to very good. The mean time (in minutes) taken for assessing the suspected adverse drug an ADR was 8. 26±2.53 for WHO-UMC scale while it was 14.18±3.44 when Naranjo scale was used.Conclusions: Both the WHO-UMC scale and Naranjo scale are reliable and valid tools for causality assessment but the Inter-rater agreement was slightly better with Naranjo as compared to WHO-UMC scale

EVALUATION OF WOUND HEALING ACTIVITY WITH A NEW FORMULATION OF DRY MANGIFERA INDICA AND HONEY USING SWISS ALBINO MICE

ABSTRACTObjective: A new formulation was made with dry M. indica power in combination with honey to understand the activity of wound healing on Swissalbino mice.Methods: Initially, animals were grouped into four groups, and a wound of 150 mm was created. All the groups were taken for the study, and woundcontraction was studied on different days. The control group was treated with saline, Vitamin E was used as standard of the care, and other groupswere treated with 200 mg/kg and 500 mg/kg of the new formulation.Results: Wound healing started after 4th2 day in the standard treated group, and the other formulation treated groups also started wound contractionfrom 2nd day onward, whereas control did not show any wound contraction after 2 day. However, significant wound contraction observed aftertreatment with 500 mg of formulation on the 10thnd day, and this cannot be compared with the standard group on the 12 day. Even good woundcontraction observed with 200 mg/kg of the formulation which is similar to that of standard treated groups. The control group showed woundcontraction of about 34.72 mm2, whereas the standard group showed 9.58 mm and the formulation-treated groups 200 mg/kg and 500 mg/kgshowed 15.39 mm2 and 8.48 mm2.2Conclusion: This observation showed that a good wound contraction observed with a new formulation.Keywords: Mangifera indica, Honey, Wound healing, Wound contraction, Swiss albino mice.t

Oral manifestations of Alagille-2 syndrome: a rare case report

Alagille-2 syndrome (AGLS-2) is a rare autosomal dominant illness that affects the Notch signalling pathway, with few studies reported in the literature related to dental science. It is recognized clinically, with anomalies of the liver, skeleton, kidneys, eyes, and face manifesting. The JAG1 gene accounts for about 97 percent of instances of Alagille syndrome variation, whereas mutations in NOTCH2 account for only 1 percent. When serum bilirubin levels in children are higher than 30 mg/dl, bilirubin builds up in dental tissue and results in varied greenish-brown dyschromia of the teeth. We discussed the dental findings of a patient diagnosed with NOTCH-2 who sought out dental treatment at the government college of dentistry in Indore, MP (India), complaining of pain and a stain in his teeth with typical features of facial dysmorphism.