High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

Purpose: This study aims to evaluate the association between high sensitivity troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). Methods: Patients undergoing cMRI were prospectively enrolled. Patients with right ventricular dysfunction(< 50%) were excluded. Blood samples for measurements of hsTn and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the time of cMRI. Results: 84 patients were included. Median left ventricular ejection fraction was 59% (IQR 51–64%). HsTn were correlated inversely with MAPSE within multivariable linear regression models (hsTnI: Beta − 0.19; T − 1.96; p = 0.05; hsTnT: Beta − 0.26; T − 3.26; p = 0.002). HsTn increased significantly according to decreasing stages of impaired MAPSE (p < 0.003). HsTn discriminated patients with impaired MAPSE < 11 mm (hsTnT: AUC = 0.67; p = 0.008; hsTnI: AUC = 0.64; p = 0.03) and < 8 mm (hsTnT: AUC = 0.79; p = 0.0001; hsTnI: AUC = 0.75; p = 0.001) and were still significantly associated in multivariable logistic regression models with impaired MAPSE < 11 mm (hsTnT: OR = 4.71; p = 0.002; hsTnI: OR = 4.22; p = 0.009). Conclusions: This study demonstrates that hsTn are able to reflect MAPSE being assessed by cMRI

Анализ причин возникновения дефектов при эксплуатации резервуаров вертикальных стальных типа РВС-20000м3 и технологии их ремонта

Объектом исследования является резервуар вертикальный стальной 20000 м³. Цель работы – рассмотрение анализа причин возникновения дефектов при эксплуатации резервуаров вертикальных стальных типа РВС 20000 м3 и технологии их ремонта. В процессе исследования проводились расчетов строительных конструкций вертикального стального резервуара. В результате исследования анализа дефектов РВС 20000. На основании полученных результатов было выявлено, что применение ремонтных работ, которая увеличивает срок эксплуатации трубопровода. Основные конструктивные, технологические и технико-эксплуатационные характеристики: технология и организация выполнения работ, подготовительные работы, земляные работы, монтаж резервуара, сварочно-монтажные работы резервуара.The object of study is the vertical steel tank of 20000 m3. The aim of this work is the consideration of the analysis of the causes of defects in the operation of vertical steel tanks type RVS 20000 m3 and repair technology. In the process the research was carried out calculations of building structures vertical steel tank. The study analysis of the defects of RVS 20000. On the basis of obtained results it was found that the use of repairs, which increases the lifetime of the pipeline. The basic constructive, technological and technical performance: technology and organization of implementation of works, preparatory work, excavation work, tank installation, welding and installation works of tank

Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score

Background: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). Methods: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD. Within 24 h of CCT examination, peripheral blood samples were taken to measure cardiac biomarkers hs-cTnI and hs-cTnT. Results: A total of 76 patients were enrolled including 38% without detectable CAC, 36% with an Agatston score from 1 to 100, 17% from 101 to 400, and 9% with values ≥ 400. hs-cTnI was increasing alongside Agatston score and was able to differentiate between different groups of Agatston scores. Both hs-cTn discriminated values greater than 100 (hs-cTnI, AUC = 0.663; p = 0.032; hs-cTnT, AUC = 0.650; p = 0.048). In univariate and multivariate logistic regression models, hs-cTnT and hs-cTnI were significantly associated with increased Agatston scores. Patients with hs-cTnT ≥ 0.02 µg/l and hs-cTnI ≥ 5.5 ng/l were more likely to reveal values ≥ 400 (hs-cTnT; OR = 13.4; 95% CI 1.545–116.233; p = 0.019; hs-cTnI; OR = 8.8; 95% CI 1.183–65.475; p = 0.034). Conclusion: The present study shows that the Agatston score was significantly correlated with hs cardiac troponins, both in univariable and multivariable linear regression models. Hs-cTnI is able to discriminate between different Agatston values. The present results might reveal potential cut-off values for hs cardiac troponins regarding different Agatston values. Trial registration Cardiovascular Imaging and Biomarker Analyses (CIBER), NCT03074253 https://clinicaltrials.gov/ct2/show/record/NCT0307425

Untersuchung des intraabdominellen Druckes im Verlauf der Laparostomatherapie

Background: In the surgical therapy of mechanical obstruction, peritonitis or trauma, the primary closure of the abdominal wall is frequently impossible. Objective parameters for determination of the abdominal wall closure after laparostomy are not known yet. So far, the intra-abdominal pressure (IAD) has not been evaluated as a criterion regarding the feasibility of fascial closure.Patients and Methods: The intravesical pressure (IVD) was used to assess IAD. The resulting IVD was compared with the IAD of two control groups. 15 patients were examined during laparoscopic surgery. IVD was measured during pneumoperitoneum and was compared to the IAD of the Laparoflator. The second control group consisted of 100 patients undergoing elective abdominal surgery (resection of the small bowel (12%), colo-rectal resection (28%), multivisceral resection (27%)). IVD was measured immediate after surgery. The studygroup consisted of 42 patients a laparostomy was applied to (24 female/18 male). The average age was 58,1 ± 17,2 years. Indication for applying a laparostomy were peritonitis (43%, average MPI 31), intestinal ischemia (27%), mechanical obstruction (21%), intraabdominal bleeding (7%) and trauma (2%). There was a standard procedure to apply the Laparostoma: After median laparotomy a net of polyglactin (Vicryl®, Ethicon, Hamburg) with the size 28 x 18 cm was sutured (1er Vicryl, Ethicon) to the abdominal wall. In 23 of 42 patients (55%), the definite closure of the abdomen was performed. In this group IVD was evaluated for seen days: three days before and three days after closure of the abdomen and at the day of surgery. Furthermore, parameters of ardio-circulatory, renal, pulmonary and liver function were recorded. The APACHE II Score was recorded. For statistical analysis, t-test and analysis of variance (ANOVA) were used. Significant was p < 0,05. To compare the agreement of IVD and pressure of the Laparoflator, the approach of Bland and Altman was used

Untersuchung des intraabdominellen Druckes im Verlauf der Laparostomatherapie

Background: In the surgical therapy of mechanical obstruction, peritonitis or trauma, the primary closure of the abdominal wall is frequently impossible. Objective parameters for determination of the abdominal wall closure after laparostomy are not known yet. So far, the intra-abdominal pressure (IAD) has not been evaluated as a criterion regarding the feasibility of fascial closure.Patients and Methods: The intravesical pressure (IVD) was used to assess IAD. The resulting IVD was compared with the IAD of two control groups. 15 patients were examined during laparoscopic surgery. IVD was measured during pneumoperitoneum and was compared to the IAD of the Laparoflator. The second control group consisted of 100 patients undergoing elective abdominal surgery (resection of the small bowel (12%), colo-rectal resection (28%), multivisceral resection (27%)). IVD was measured immediate after surgery. The studygroup consisted of 42 patients a laparostomy was applied to (24 female/18 male). The average age was 58,1 ± 17,2 years. Indication for applying a laparostomy were peritonitis (43%, average MPI 31), intestinal ischemia (27%), mechanical obstruction (21%), intraabdominal bleeding (7%) and trauma (2%). There was a standard procedure to apply the Laparostoma: After median laparotomy a net of polyglactin (Vicryl®, Ethicon, Hamburg) with the size 28 x 18 cm was sutured (1er Vicryl, Ethicon) to the abdominal wall. In 23 of 42 patients (55%), the definite closure of the abdomen was performed. In this group IVD was evaluated for seen days: three days before and three days after closure of the abdomen and at the day of surgery. Furthermore, parameters of ardio-circulatory, renal, pulmonary and liver function were recorded. The APACHE II Score was recorded. For statistical analysis, t-test and analysis of variance (ANOVA) were used. Significant was p < 0,05. To compare the agreement of IVD and pressure of the Laparoflator, the approach of Bland and Altman was used

Farewell to thee, lady, farewell, ballad /

In bound volumes: Copyright Deposits 1820-186