Purpose: This study aims to evaluate the association between high sensitivity troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI).   

Methods: Patients undergoing cMRI were prospectively enrolled. Patients with right ventricular dysfunction(< 50%) were excluded. Blood samples for measurements of hsTn and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the time of cMRI.   

Results: 84 patients were included. Median left ventricular ejection fraction was 59% (IQR 51–64%). HsTn were correlated inversely with MAPSE within multivariable linear regression models (hsTnI: Beta − 0.19; T − 1.96; p = 0.05; hsTnT: Beta − 0.26; T − 3.26; p = 0.002). HsTn increased significantly according to decreasing stages of impaired MAPSE 

(p < 0.003). HsTn discriminated patients with impaired MAPSE < 11 mm (hsTnT: AUC = 0.67; p = 0.008; hsTnI: AUC = 0.64; p = 0.03) and < 8 mm (hsTnT: AUC = 0.79; p = 0.0001; hsTnI: AUC = 0.75; p = 0.001) and were still significantly associated in multivariable logistic regression models with impaired MAPSE < 11 mm (hsTnT: OR = 4.71; p = 0.002; hsTnI: OR = 4.22; p = 0.009).   Conclusions: This study demonstrates that hsTn are able to reflect MAPSE being assessed by cMRI

Akin, Ibrahim

Behnes, Michael

Bertsch, Thomas

Borggrefe, Martin

Budjan, Johannes

Hoffmann, Julia

Hoffmann, Ursula

Kim, Seung-Hyun

Lang, Siegfried

Natale, Michèle

Papavassiliu, Theano

Reckord, Nadine

European Journal of Medical Research

Abstract Purpose This study aims to evaluate the association between high sensitivity troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI). Methods Patients undergoing cMRI were prospectively enrolled. Patients with right ventricular dysfunction (< 50%) were excluded. Blood samples for measurements of hsTn and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the time of cMRI. Results 84 patients were included. Median left ventricular ejection fraction was 59% (IQR 51–64%). HsTn were correlated inversely with MAPSE within multivariable linear regression models (hsTnI: Beta − 0.19; T − 1.96; p = 0.05; hsTnT: Beta − 0.26; T − 3.26; p = 0.002). HsTn increased significantly according to decreasing stages of impaired MAPSE (p < 0.003). HsTn discriminated patients with impaired MAPSE < 11 mm (hsTnT: AUC = 0.67; p = 0.008; hsTnI: AUC = 0.64; p = 0.03) and < 8 mm (hsTnT: AUC = 0.79; p = 0.0001; hsTnI: AUC = 0.75; p = 0.001) and were still significantly associated in multivariable logistic regression models with impaired MAPSE < 11 mm (hsTnT: OR = 4.71; p = 0.002; hsTnI: OR = 4.22; p = 0.009). Conclusions This study demonstrates that hsTn are able to reflect MAPSE being assessed by cMRI

Michèle Natale

Michael Behnes

Seung-Hyun Kim

Julia Hoffmann

Nadine Reckord

Ursula Hoffmann

Johannes Budjan

Siegfried Lang

Martin Borggrefe

Theano Papavassiliu

Thomas Bertsch

Ibrahim Akin

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High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

Following publication of the original article [1], the authors reported that there was a mistake in the Methods section → Measurements of biomarkers (page 6, line 3): 2000g should read 2500g. So, the correct sentence should be “All samples were obtained by venipuncture into serum monovettes® and centrifuged at 2500g for 10 min at 20 °C.

Hofmann, Julia

Hofmann, Ursula

Heidelberger Dokumentenserver

Natale et al. Eur J Med Res  (2018) 23:9 https://doi.org/10.1186/s40001-018-0306-0CORRECTIONCorrection to: High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imagingMichèle Natale1, Michael Behnes1*, Seung‑Hyun Kim1, Julia Hofmann1, Nadine Reckord1, Ursula Hofmann1, Johannes Budjan2, Siegfried Lang1, Martin Borggrefe1, Theano Papavassiliu1, Thomas Bertsch3 and Ibrahim Akin1© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Correction to:  Eur J Med Res (2017) 22:38  https://doi.org/10.1186/s40001‑017‑0281‑xFollowing publication of the original article [1], the authors reported that there was a mistake in the Methods section → Measurements of biomarkers (page 6, line 3): 2000g should read 2500g. So, the correct sentence should be “All samples were obtained by venipuncture into serum  monovettes® and centrifuged at 2500g for 10 min at 20 °C.”Author details1 First Department of Medicine, Faculty of Medicine Mannheim, Uni‑versity Medical Center Mannheim (UMM), University of Heidelberg, Theodor‑Kutzer‑Ufer 1‑3, 68167 Mannheim, Germany. 2 Institute of Clinical Radiology and Nuclear Medicine, Faculty of Medicine Mannheim, University Medical Center Mannheim (UMM), University of Heidelberg, Mannheim, Germany. 3 Institute of Clinical Chemistry, Laboratory Medicine and Transfu‑sion Medicine, General Hospital Nuremberg, Paracelsus Medical University, Nuremberg, Germany. Publisher’s NoteSpringer Nature remains neutral with regard to jurisdictional claims in pub‑lished maps and institutional affiliations.Received: 8 February 2018   Accepted: 8 February 2018Reference 1. Natale M, Behnes M, Kim S‑H, Hofmann J, Reckord N, Hofmann U, Budjan J, Lang S, Borggrefe M, Papavassiliu T, Bertsch T, Akin I. High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging. Eur J Med Res. 2017;22:38. https://doi.org/10.1186/s40001‑017‑0281‑x.Open AccessEuropean Journalof Medical Research*Correspondence:  michael.behnes@umm.de 1 First Department of Medicine, Faculty of Medicine Mannheim, University Medical Center Mannheim (UMM), University of Heidelberg, Theodor‑Kutzer‑Ufer 1‑3, 68167 Mannheim, GermanyFull list of author information is available at the end of the articleThe original article can be found online at https://doi.org/10.1186/s40001‑017‑0281‑x.

Correction to: High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

Abstract Following publication of the original article [1], the authors reported that there was a mistake in the Methods section → Measurements of biomarkers (page 6, line 3): 2000g should read 2500g. So, the correct sentence should be “All samples were obtained by venipuncture into serum monovettes® and centrifuged at 2500g for 10 min at 20 °C.

Julia Hofmann

Ursula Hofmann

http://link.springer.com/article/10.1186/s40001-017-0281-x

High sensitivity troponin T and I reflect mitral annular plane systolic excursion being assessed by cardiac magnetic resonance imaging

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Directory of Open Access Journals

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