Pulmonary alveolar proteinosis in a marble worker

Pulmonary alveolar proteinosis (PAP) is a rarely seen disease of the alveoli, characterized by accumulation of proteinous material, which stains positive with periodic acid Schiff, in the alveoli. Secondary PAP may develop as a result of occupational exposure to materials such as silica and indium. In the paper, together with a review of the relevant literature, we present an uncommon case of a 47-year old male, marble worker who was diagnosed with PAP associated with a 12-year history of exposure to marble dust. Int J Occup Med Environ Health 2016;29(5):871–87

Pulmonary alveolar proteinosis in a marble worker

Pulmonary alveolar proteinosis (PAP) is a rarely seen disease of the alveoli, characterized by accumulation of proteinous material, which stains positive with periodic acid Schiff, in the alveoli. Secondary PAP may develop as a result of occupational exposure to materials such as silica and indium. In the paper, together with a review of the relevant literature, we present an uncommon case of a 47-year old male, marble worker who was diagnosed with PAP associated with a 12-year history of exposure to marble dust. Int J Occup Med Environ Health 2016;29(5):871–87

Endobronchial Lipoma Presenting with Localised Wheezes: A Case Report

A 67-year-old non-smoking man was referred to our clinic with dry cough and shortness of breath during exercise over the course of 6 months. The physical examination was unremarkable except for the presence of isolated localised wheezes over the left upper lung. His chest X-ray was normal. A computed tomography (CT) scans of chest revealed an irregular and partial obstruction of the left upper lobe bronchus with soft-tissue density lesion. Bronchoscopy revealed the presence of a smooth surface tumour occluding the orifice of the lingula bronchus. The lesion and its stalk were totally removed by cutting with forceps. After the removal of the lesion, patient's dyspnoea and wheezes were disappeared completely. Histopathological examination of the lesion was reported as endobrochial lipoma (EL). At the 2-years follow-up period, the patient was remained asymptomatic. We present a case report of an unusual presentation of EL with localised wheezes and without the presence of fat density on CT scanning. [Med-Science 2015; 4(4.000): 2897-902

Effect of Resveratrol on Treatment of Bleomycin-Induced Pulmonary Fibrosis in Rats

Resveratrol has a preventive potential on bleomycin-induced pulmonary fibrosis in prophylactic use; however, it was not studied in the treatment of the fibrosis. This study investigated the role of resveratrol on the treatment of bleomycin-induced pulmonary fibrosis. Intratracheal bleomycin (2.5 mg/kg) was given in fibrosis groups and saline in controls. First dose of resveratrol was given 14 days after bleomycin and continued until sacrifice. On 29th day, fibrosis in lung was estimated by Aschoft's criteria and hydroxyproline content. Bleomycine increased the fibrosis score (3.70 +/- 1.04) and hydroxyproline levels (4.99 +/- 0.90 mg/g tissue) as compared to control rats (1.02 +/- 0.61 and 1.88 +/- 0.59 mg/g), respectively. These were reduced to 3.16 +/- 1.58 (P = 0.0001) and 3.08 +/- 0.73 (P > 0.05), respectively, by resveratrol. Tissue malondialdehyde levels in the bleomycin-treated rats were higher (0.55 +/- 0.22 nmol/mg protein) than that of control rats (0.16 +/- 0.07; P = 0.0001) and this was reduced to 0.16 +/- 0.06 by resveratrol (P = 0.0001). Tissue total antioxidant capacity is reduced (0.027 +/- 0.01) by bleomycine administration when compared control rats (0.055 +/- 0.012 mmol Trolox Equiv/mg protein; P = 0.0001) and increased to 0.041 +/- 0.008 (P = 0.001) by resveratrol. We concluded that resveratrol has some promising potential on the treatment of bleomycin-induced pulmonary fibrosis in rats. However, different doses of the drug should be further studied

An Unusual Case of Tracheobronchial Foreign Body Aspiration in a Laryngectomized Patient: Rolled Tissue

Tracheobronchial foreign body aspirations are the most common cause of acute respiratory obstruction and vital health problem that have to be diagnosed and managed immediately. Aspiration can lead to serious consequences up to respiratory arrest, if complete or near complete airway obstruction occurs or intervention is delayed. The existence of tracheal stoma after previous surgeries is an important factor that facilitates foreign body aspiration. In this article we present a case with total laryngectomy who aspirated roll of tissue when he tried to clean tracheal stoma. It is very important to keep in mind the possibility of foreign body aspiration through stoma in tracheotomized patients presented with respiratory comprimise. Immediate diagnosis and proper intervention of this situation is lifesaving. [Med-Science 2015; 4(2.000): 2263-70

Predictors of successful percutaneous transvenous mitral commissurotomy using the Bonhoeffer Multi-Track system in patients with moderate to severe mitral stenosis: Can we see beyond the Wilkins score?

WOS: 000362968700017PubMed: 26477725To the Editor, We read the original investigation entitled “Predictors of successful percutaneous transvenous mitral commissurotomy using the Bonhoeffer Multi-Track system in patients with moderate to severe mitral stenosis: Can we see beyond the Wilkins score?” by Farman et al. (1) published in the Anatol J Cardiol 2015; 15: 373-9. with great interest. We would like to touch on some points regarding this article

The effects of treatment in patients with childhood asthma on the elastic properties of the aorta

WOS: 000405948700008PubMed: 28759088Introduction: The study aimed to investigate the effects of treatment in patients with childhood asthma on the elastic properties of the aorta and cardiovascular risk. Methods: The study was performed in 66 paediatric patients diagnosed with bronchial asthma (BA). All patients were administered the beta(2) agonist, salbutamol, for seven days, followed by one month of montelukast and six months of inhaled steroid treatment. All patients underwent conventional transthoracic echocardiographic imaging before and after treatment. Aortic elasticity parameters were considered to be the markers of aortic function. Results: Aortic elasticity parameters, including aortic strain (15.2 +/- 4.8 and 18.8 +/- 9.5%, p = 0.043), aortic distensibility (7.26 +/- 4.71 and 9.53 +/- 3.50 cm(2)/dyn, p = 0.010) and aortic stiffness index (3.2 +/- 0.6 and 2.8 +/- 0.5, p = 0.045 showed significant post-treatment improvement when compared to pre-treatment values. Tricuspid annular plane systolic excursion (TAPSE) was also observed to improve after treatment (1.81 +/- 0.38 and 1.98 +/- 0.43, p = 0.049). Conclusion: The study demonstrated that when provided at appropriate doses, medications used in BA may result in an improvement in aortic stiffness