15 research outputs found
Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletion
Projected Lifetime Healthcare Costs Associated with HIV Infection.
OBJECTIVE: Estimates of healthcare costs associated with HIV infection would provide valuable insight for evaluating the cost-effectiveness of possible prevention interventions. We evaluate the additional lifetime healthcare cost incurred due to living with HIV. METHODS: We used a stochastic computer simulation model to project the distribution of lifetime outcomes and costs of men-who-have-sex-with-men (MSM) infected with HIV in 2013 aged 30, over 10,000 simulations. We assumed a resource-rich setting with no loss to follow-up, and that standards and costs of healthcare management remain as now. RESULTS: Based on a median (interquartile range) life expectancy of 71.5 (45.0-81.5) years for MSM in such a setting, the estimated mean lifetime cost of treating one person was £ 360,800 (291,000 or € 246,000). The largest proportion (68%) of these costs was attributed to antiretroviral drugs. If patented drugs are replaced by generic versions (at 20% cost of patented prices), estimated mean lifetime costs reduced to £ 179,000 ( 158,900 or € 134,600) discounted. CONCLUSIONS: If 3,000 MSM had been infected in 2013, then future lifetime costs relating to HIV care is likely to be in excess of £ 1 billion. It is imperative for investment into prevention programmes to be continued or scaled-up in settings with good access to HIV care services. Costs would be reduced considerably with use of generic antiretroviral drugs
The Incidence of AIDS-Defining Illnesses at a Current CD4 Count ≥200 Cells/µL in the Post-Combination Antiretroviral Therapy Era
The incidence of AIDS was higher in patients with a current CD4 count of 500-749 cells/µL compared to 750-999 cells/µL, but did not decrease further at higher CD4 levels. Results were similar in those virologically suppressed on combination antiretroviral therapy, suggesting immune reconstitution is incomplete until CD4 >750/µ
Ongoing changes in HIV RNA levels during untreated HIV infection:Implications for CD4 cell count depletion
Age-and Sex-specific Death Rates in ART-naïve Patients with CD4 Count above 350 cells/m³ Compared with the General Population
Study Group on Death Rate at High CD4 Count in Antoretroviral-naïve patientsinfo:eu-repo/semantics/nonPublishe
Distribution of costs spent in an average lifetime in base case analysis.
<p>Distribution of costs spent in an average lifetime in base case analysis.</p
Distribution of costs spent in an average lifetime in analysis if patented drugs are replaced by generic versions.
<p>Distribution of costs spent in an average lifetime in analysis if patented drugs are replaced by generic versions.</p