30 research outputs found

    Radio frequency interference and lightning studies of a square Kilometre Array demonstrator structure

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    We study the radio frequency interference and lightning protection of the South African Square Kilometre Array demonstrator: the Karoo Array Telescope. Increasingly-realistic scale models of the demonstrator have been built and computationally modeled using FEKO. Minimally-invasive S-parameter measurements are made on physical scale models in an anechoic chamber with good agreement to simulation. The modeling has enabled insightful investigations into current paths and field distributions for interference mitigation and structure lightning protection, with direct bearing on the demonstrator implementation. © 2011 IEEE.Articl

    Karoo array telescope: Lightning protection issues and RFI

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    Please help us populate SUNScholar with the post print version of this article. It can be e-mailed to: [email protected]

    Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment

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    Contains fulltext : 144496.pdf (publisher's version ) (Open Access)Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding of underlying genetic mechanisms has proved challenging. In this study, we use molecular genetic techniques to investigate an admixed isolated founder population from the Robinson Crusoe Island (Chile), who are affected by a high incidence of SLI, increasing the power to discover contributory genetic factors. We utilize exome sequencing in selected individuals from this population to identify eight coding variants that are of putative significance. We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 x 10-4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. We conclude that coding variants within NFXL1 confer an increased risk of SLI within a complex genetic model
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