On the semiclassical Laplacian with magnetic field having self-intersecting zero set

This paper is devoted to the spectral analysis of the Neumann realization of the 2D magnetic Laplacian with semiclassical parameter h > 0 in the case when the magnetic field vanishes along a smooth curve which crosses itself inside a bounded domain. We investigate the behavior of its eigenpairs in the limit h $\rightarrow$ 0. We show that each crossing point acts as a potential well, generating a new decay scale of h 3/2 for the lowest eigenvalues, as well as exponential concentration for eigenvectors around the set of crossing points. These properties are consequences of the nature of associated model problems in R 2 for which the zero set of the magnetic field is the union of two straight lines. In this paper we also analyze the spectrum of model problems when the angle between the two straight lines tends to 0

Cross-validating administrative and survey datasets through microsimulation and the assessment of a tax reform in Luxembourg

Using EUROMOD, we cross-validate two types of micro-data presently available in the Grand-Duchy of Luxembourg, administrative data on one hand and survey data on the other hand. While administrative data, extracted from the recently implemented Social Security Data Warehouse, contain information of the whole population of Luxembourg (449,000 observations) in 2003, survey data, extracted from the Luxembourg household panel PSELL3/EU-SILC for 2004 (incomes from 2003), is a representative sample of around 3,600 private households (9,800 individuals) living in Luxembourg with detailed information on incomes, household structure and other socio-economic dimensions. As a concrete application of this cross-validation, we analyze the 2001-2002 tax reform in Luxembourg. The main aspects of this reform are the reduction of the number of the tax brackets and the fall of the maximal marginal tax rate (from 46% in 2000 to 42% in 2001 and to 38% in 2002). The distributional effects of the tax reform are measured in terms of losers and winners, change in inequalities and poverty rates. The results issued from different types of input data are compared for cross-validation and allow us to emphasize methodological difficulties as well as to underline the advantages and limitations of each dataset.EUROMOD ; Microsimulation ; Tax reform ; Validation

Prospects for Measuring Planetary Spin and Frame-Dragging in Spacecraft Timing Signals

Satellite tracking involves sending electromagnetic signals to Earth. Both the orbit of the spacecraft and the electromagnetic signals themselves are affected by the curvature of spacetime. The arrival time of the pulses is compared to the ticks of local clocks to reconstruct the orbital path of the satellite to high accuracy, and to implicitly measure general relativistic effects. In particular, Schwarzschild space curvature (static) and frame-dragging (stationary) due to the planet's spin affect the satellite's orbit. The dominant relativistic effect on the path of the signal photons is Shapiro delay due to static space curvature. We compute these effects for some current and proposed space missions, using a Hamiltonian formulation in four dimensions. For highly eccentric orbits, such as in the Juno mission and in the Cassini Grand Finale, the relativistic effects have a kick-like nature, which could be advantageous for detecting them if their signatures are properly modeled as functions of time. Frame-dragging appears, in principle, measurable by Juno and Cassini, though not by Galileo 5 and 6. Practical measurement would require disentangling frame-dragging from the Newtonian 'foreground' such as the gravitational quadrupole which has an impact on both the spacecraft's orbit and the signal propagation. The foreground problem remains to be solved.Comment: 10 pages, 6 figures, provisionally accepted for publication in Frontiers in Astronomy and Space Sciences, section Fundamental Astronom

Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol: histopathological analysis

The digestive tract is a target for the mycotoxin deoxynivalenol (DON), a major cereals grain contaminant of public health concern in Europe and North America. Pig, the most sensitive species to DON toxicity, can be regarded as the most relevant animal model for studying the intestinal effects of DON. A pig jejunal explants culture was developed to assess short-term effects of DON. In a first step, jejunal explants from 9-13 week-old and from 4-5 week-old pigs were cultured in vitro for up to 8 hours. Explants from younger animals were better preserved after 8 hours, as assessed by morphological scores and by villi lengths. In a second step, dose-related alterations of the jejunal tissue were observed, including shortened and coalescent villi, lysis of enterocytes, oedema. After 4h of DON exposure of explants from 4-5 week-old pigs, a no-effect concentration level of 1 µM was estimated (corresponding to diet contaminated with 0.3 mg DON/kg) based on morphological scores, and of 0.2 µM based on villi lengths. In conclusion, our data indicate that pig intestinal explants represent a relevant and sensitive model to investigate the effects of food contaminants

An Improved Physics-Based Formulation of the Microwave p-i-n Diode Impedance

International audienceAn improved formulation of the frequency-dependent impedance for p-i-n diodes from physical and geometrical parameters is presented. This work is addressed to diode designers and allows them to evaluate quickly and accurately the diode impedance. It comes in parallel with existing SPICE p-i-n diode model [1] used in CAD software. Under forward bias conditions, important recombinations occur in the heavily doped end regions of thin p-i-n diodes that seriously affects the diode impedance. This effect is taken into account to increase the accuracy of existing numerical models and to extend their validity domain to any I-region thicknesses. This improvement has been validated by measurement results on a 5- m I-region width silicon p-i-n diode

Modulation of granulocyte LAM-1 and MAC-1 during dialysis—A prospective, randomized controlled trial

Modulation of granulocyte LAM-1 and MAC-1 during dialysis—A prospective, randomized controlled trial. Hemodialysis with first-use cellulosic dialysis membranes results in activation of the alternative pathway of complement and profound neutropenia followed by rebound leukocytosis. The neutropenia has been shown to be associated with increased expression of adhesion receptors and pulmonary sequestration of granulocytes. However, the mechanism underlying the return of the granulocytes has not been elucidated. We determined simultaneously the changes in the granulocyte adhesion receptor MAC-1 (CD11b-CD18) and the selectin LAM-1 receptor during dialysis using a complement activating and a non-complement activating membrane, in a randomized, cross-over study. With initiation of dialysis with cellulosic membranes, there was a rapid and prominent increase in the expression of MAC-1 receptors. At the nadir of granulocyte count, 15 minutes after initiation of dialysis with the complement activating membrane, there was a four-fold increase in the MAC-1 receptor expression. At the same time, there was a two-fold decrease in LAM-1 expression. There were no changes in the expression of two other granulocyte receptors CD 11a and CD 15 which are known not to be modulated during granulocyte activation. Granulocytes harvested during dialysis and which had high MAC-1 and low LAM-1 expression had a significantly decreased adherence to endothelial cell monolayers. Dialysis of the same patients with non-complement activating membranes resulted in no significant change in the expression of these receptors on granulocytes nor in their adherence to endothelial cells. These results shed new light on the mechanism of the cyclical granulocytopenia and rebound granulocytosis during dialysis with new cellulosic membranes

A method for measuring the acoustic properties of a porous sample mounted in a rigid ring in acoustic tubes

International audienceThis study presents a method to measure the acoustic properties of a homogeneous porous material with a support or a reduction element in an acoustic tube. Some materials tested have a lateral size much smaller than the tube's diameter, as they cannot be produced in the correct dimensions without corrupting the material; this also permits the testing of the same samples in a large frequency bandwidth by using different section tubes. Moreover, the acoustic leaks on the material boundaries can significantly change the transmission loss measured in tubes. To rectify these problems, rings can be placed on each material surface. The presence of these rings can influence the acoustic indicator measurement; while this effect is negligible for tubes with a large cross section, it is not for tubes with a small cross section. To correct, or remove, the influence of the rings, we propose to use an application of the parallel assembly process of the transfer matrix method which has recently been proposed by Panneton et al. [Proceeding Internoise New York (2012)]. Measurements on classical porous materials with and without reductions are proposed and compared to simulated results. The ring's effects and the proposed corrections are discussed for different materials

Prediction of acoustic properties of parallel assemblies by means of transfer matrix method

International audienceThe Transfer Matrix Method (TMM) is used conventionally to predict the acoustic properties of laterally infinite homogeneous layers assembled in series to form a multilayer. In this work, a parallel assembly process of transfer matrices is used to model heterogeneous materials such as patchworks, acoustic mosaics, or a collection of acoustic elements in parallel. In this method, it is assumed that each parallel element can be modeled by a 2x2 transfer matrix, and no diffusion exists between elements. The method is validated by comparison with finite element method (FEM). Then, an overview of the possibilities, such as the combination of series and parallel matrices, the sound absorption coefficient and the transmission loss of a parallel array of resonators or three-dimensional geometries is presented and discussed

Cardiac Surgery in Octogenarians; Peri-Operative Outcome and Long-Term Results

AIMS: Because the elderly are increasingly referred for operation, we reviewed the results of cardiac surgery in patients of 80 years or older. METHODS AND RESULTS: Records of 182 consecutive octogenarians who had had cardiac operations between 1992 and 1998 were reviewed. Follow-up was 100% complete. Seventy patients had coronary grafting (CABG), 70 aortic valve replacement, 30 aortic valve replacement+CABG, and 12 mitral valve repair/replacement. Rates of hospital death, stroke, and prolonged stay (>14 days) were as follows: CABG: 7 (10%), 2 (2.8%) and 41 (58%); aortic valve replacement: 6 (8.5%), 2 (2.8%) and 32 (45.7%); aortic valve replacement+CABG: 8 (26.5%), 1 (3.8%) and 14 (46.6%); mitral valve repair/replacement: 3 (25%), 1 (8.3%) and 5 (41.6%). Multivariate predictors (P<0.05) of hospital death were New York Heart Association functional class, urgent procedure, prolonged cardiopulmonary bypass time, and, after aortic valve replacement, previous percutaneous aortic valvuloplasty. Ascending aortic atheromatous disease was predictive of stroke, while pre-operative myocardial infarction was predictive of prolonged hospital stay. Actuarial 5-year survival was as follows: CABG, 65.8+/-8.8%; aortic valve replacement, 63.6+/-7.1%; aortic valve replacement+CABG, 62.4+/-6.8%; mitral valve repair/replacement, 57.1+/-5.6%; and total, 63.0+/-5.6%. Multivariate predictors of late death were pre-operative myocardial infarction, and urgent procedure. Ninety percent of long-term survivors were in New York Heart Association class I or II, and 87% believed having a heart operation after age 80 years was a good choice. CONCLUSION: Cardiac operations are successful in most octogenarians with increased hospital mortality, and longer hospital stay. Long-term survival and quality of life are good

Testing scalar-tensor theories and PPN parameters in Earth orbit

We compute the PPN parameters $\gamma$ and $\beta$ for general scalar-tensor theories in the Einstein frame, which we compare to the existing PPN formulation in the Jordan frame for alternative theories of gravity. This computation is important for scalar-tensor theories that are expressed in the Einstein frame, such as chameleon and symmetron theories, which can incorporate hiding mechanisms that predict environment-dependent PPN parameters. We introduce a general formalism for scalar-tensor theories and constrain it using the limit on $\gamma$ given by the Cassini experiment. In particular we discuss massive Brans-Dicke scalar fields for extended sources. Next, using a recently proposed Earth satellite experiment, in which atomic clocks are used for spacecraft tracking, we compute the observable perturbations in the redshift induced by PPN parameters deviating from their general relativistic values. Our estimates suggest that $|\gamma - 1| \sim |\beta -1| \sim 10^{-6}$ may be detectable by a satellite that carries a clock with fractional frequency uncertainty $\Delta f/f \sim 10^{-16}$ in an eccentric orbit around the Earth. Such space experiments are within reach of existing atomic clock technology. We discuss further the requirements necessary for such a mission to detect deviations from Einstein relativity.Comment: 17 pages, 6 figures, accepted for publication in Phys. Rev.