FORMULATION AND EVALUATION OF PH-DEPENDENT COLON-TARGETED TABLETS OF RIFAXIMIN BY DESIGN OF EXPERIMENT

Objective: The research is designed at formulating and evaluating pH-sensitive rifaximin colon-targeted tablets for targeted action in proximal colon. Method: The colon-targeted tablets are done by granulation of three levels of polymers such as Eudragit L30D, Carbopol 974P, and ethyl cellulose. The evaluation parameters such as swelling studies, drug dissolution, in vitro drug release studies, stability, and the Fourier transform infrared studies carried out for optimized formulations. Results: Physicochemical parameters of all the 27 formulations (RF1-RF27) evaluated and RF21 is chosen for further investigation based on weight variation, hardness, drug content, and swelling index. The in vitro drug release studies indicate that the optimized formulation RF21 released 98.75% drug within 24 h. The stability studies indicate that the formulation is stable. Conclusion: An effective and stable pH-dependent rifaximin colon-targeted tablet formulated for the targeted treatment of bowel syndrome

Camel Milk as Adjuvant to Treat Alloxan Diabetes: Effect of Heat Treatment on this Property

Diabetes is one of the most frequent and serious chronic diseases in humans all over the world. The aim of our study was to evaluate the effect of heat treatment on antidiabetic activity of camel milk on serum glucose and lipid profile of alloxan-induced diabetic rats. Diabetes was induced in Wistar albino rats by intraperitoneal injection of alloxan (120 mg/kg BW once). Albino rats each weighing 180-230g were divided into 3 equal groups (n=4) as following: G1- normal rats fed on normal diet, G2 - diabetic rats fed on normal diet, and G3 - diabetic rats were fed with raw camel milk. Fasting blood glucose was measured lipid profile was assessed. Results: Our study showed a significant effect of raw camel milk on blood glucose and lipid profile parameters in alloxan induced diabetic rats, there was a significant reduction in lipid profile of T. Cholesterol, Triglycerides, LDL-C in (Diabetic+ Raw camel milk) comparing to (Diabetic+ Pasteurized camel milk) and Positive control group with values 121.4 mg/dl, 80.4 mg/dl, 17.9 mg/dl and 141.5 mg/dl, 90.7 mg/dl, 28.7 mg/dl and 181.6 mg/dl, 113.8 mg/dl, 48.9 mg/dl respectively. Diabetic+ Boiled camel milk group died at the end of experiment. Conclusion: Raw camel milk improved the glycemic and lipid profile in diabetic rats but not in Diabetic+ Boiled camel milk group. These findings indicate that boiling of raw camel milk may have reducing potential benefits in the treatment of diabetes. Future studies will be needed to establish its safety and mechanism of action

Comparison of stopped delay between field measurements and HCM 2010 estimations at actuated signalized intersections

The Highway Capacity Manual 2010 methodology of capacity analysis is widely used for performance evaluation of signalized intersections. However, very few studies have been performed to validate the HCM delay estimation model. This thesis aims to study the accuracy of the HCM 2010 delay estimation methodology for actuated signalized intersections using field data. The HCM stopped delay estimates were statistically compared with the field measurements for six signalized intersections along an actuated-coordinated corridor during four time periods of day, namely AM peak, off peak, noon peak, and PM peak. Overall, the HCM estimates were not significantly different from the field data only for 38.1% of the comparisons (32 cases out of 84). In the significant discrepancies, 74.2% of the HCM overestimations were on the minor streets (23 cases out of 31) and 95.2% of the underestimations were on the major street (20 cases out of 21). Hence, HCM significantly overestimated the delay on minor streets most of the time and significantly underestimated on major streets almost all the time. The over- and underestimation trend was verified for each intersection as well as each time period. In light of this trend, some insight is provided into the causes of observed discrepancies and recommendations are made for future studies

Group Stiffness and Group Fixed End Stresses in Structural Analysis

Civil Engineerin

SYNTHESIS OF TETRA-SUBSTITUTED IMIDAZOLE DERIVATIVES BY CONDENSATION REACTION USING ZEOLITE H-ZSM 22 AS A HETEROGENEOUS SOLID ACID CATALYST

Objective: The present work deals with the synthesis of tetrasubstituted imidazoles using environmentally benign and green catalyst H-ZSM-22. Methods: The synthesized catalyst was characterized by FTIR, XRD and the products by FTIR and NMR. Results: H-ZSM-22 has been used as an efficient catalyst for an improved and rapid synthesis of 1,2,4,5 tetrasubstituted imidazoles derivatives using reactants: Benzil, Aldehydes, Amines and Ammonium acetate having excellent yield under solvent conditions. Different derivatives of aldehyde have been used in this reaction. For all the synthesized derivatives, ambient reaction time was found to be of 15-30 min. Conclusion: The main advantage of this reaction is small reaction time, high purity yield, easy work-up and pollution free

Zeolite H-ZSM-5: an Efficient and Reusable Catalyst for One-Pot Synthesis of Amidoalkyl Naphthols under Solvent-Free Conditions

Zeolites have been used as an excellent and highly efficient catalyst for one-pot synthesis of amidoalkyl naphthols. This route involves multicomponent reaction of 2-napthol, various aromatic aldhydes and amide in presence of catalyst Zeolite H-ZSM-5 under solvent free condition. The synthesized Zeolite was characterized by XRD, FTIR and SEM. The products were characterized by FTIR and 1H-NMR. The method involves shorter reaction time, simple procedure, easy workup and the products are obtained in excellent yield

Possible intrusive food interaction with oral dabigatran’s anticoagulant activity in a rat models

Purpose: To evaluate the synergistic or antagonistic interaction between oral dabigitran etexilate (Pradaxa) and some foods.Methods: Aqueous extracts of sweet orange, cabbage, ginger, green tea, garlic and pineapple were prepared and lyophilized, and total phenolic acids and flavonoid contents evaluated. The residues of the aqueous extracts were given daily to the rats (500 mg/kg dose, oral) 1 h after administration of dabigatran (1.83 mg/kg dose) for 14 days. Bleeding time, International Normalized Ratio (INR), prothrombin time (PT) as well as alanine  aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in blood were measured.Results: Oral administration of Pradaxa with all the test food (except  cabbage) significantly increased bleeding time, INR and PT. Pradaxa  interaction with cabbage significantly decreased bleeding tendencies but the drug did not produce any major elevation of liver enzyme levels (ALT, AST and ALP). Conversely, significant elevation in ALP level was observed only after aqueous extract of ginger was administered with Pradaxa. Green tea and garlic significantly increased ALT and AST levels.Conclusion: Synergistic interaction occurrs between dabigatran etexilate with the selected foods, but interaction with cabbage antagonistic.Keywords: Dabigatran etexilate, Anticoagulant, Foods, Liver enzymes, International Normalized Ratio, Prothrombin tim

The Role of Exosomal miR-181c-3p Within the Ovarian Tumor Microenvironment

https://openworks.mdanderson.org/sumexp22/1034/thumbnail.jp

SHOPPING MALL AIR DISTRIBUTION SYSTEM

The objective to design Heating, Ventilation & Air conditioning (HVAC) system for a commercial Building, with simultaneously controls its temperature, humidity, cleanliness, proper distribution, noise level, heat load calculation, fresh air, exhaust, duct design, pipe design, equipment selection and layout of accessories such as indoor and outdoor unit of the project. Cooling load will be calculated on E20 form. Indeed, today the emphasis is no more on understanding air conditioning ‘products’ but on creating ‘solutions’ and not just solutions, but ‘customized solutions’ that suit specific cooling needs of specific business and establishment

OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer

Background: Given the estimate that 30% of our genes are controlled by microRNAs, it is essential that we understand the precise relationship between microRNAs and their targets. OncomiRs are microRNAs (miRNAs) that have been frequently shown to be deregulated in cancer. However, although several oncomiRs have been identified and characterized, there is as yet no comprehensive compilation of this data which has rendered it underutilized by cancer biologists. There is therefore an unmet need in generating bioinformatic platforms to speed the identification of novel therapeutic targets. Description: We describe here OncomiRdbB, a comprehensive database of oncomiRs mined from different existing databases for mouse and humans along with novel oncomiRs that we have validated in human breast cancer samples. The database also lists their respective predicted targets, identified using miRanda, along with their IDs, sequences, chromosome location and detailed description. This database facilitates querying by search strings including microRNA name, sequence, accession number, target genes and organisms. The microRNA networks and their hubs with respective targets at 3'UTR, 5'UTR and exons of different pathway genes were also deciphered using the 'R' algorithm. Conclusion: OncomiRdbB is a comprehensive and integrated database of oncomiRs and their targets in breast cancer with multiple query options which will help enhance both understanding of the biology of breast cancer and the development of new and innovative microRNA based diagnostic tools and targets of therapeutic significance