Challenges in the preservation of electronic information in digital era

Digital library is an increasingly wide range of digital resources from formally published e-journals, e-books through databases and datasets in many formats. The development of networked environment explores the challenges before the working library professional, archivist and information scientist to preserve the electronic information in the Digital era. Selected four major key areas ie. Internet, IPR, Security and Data format and discussed its present situation and barriers to preserve the electronic collection . Highlighted some important solutions pointed out by the Joint Information System Committee, UK . and National Digital Library Federation and Research Library Groups, Australia

A membrane paradigm at large D

We study $SO(d+1)$ invariant solutions of the classical vacuum Einstein equations in $p+d+3$ dimensions. In the limit $d \to \infty$ with $p$ held fixed we construct a class of solutions labelled by the shape of a membrane (the event horizon), together with a `velocity' field that lives on this membrane. We demonstrate that our metrics can be corrected to nonsingular solutions at first sub-leading order in $\frac{1}{d}$ if and only if the membrane shape and `velocity' field obey equations of motion which we determine. These equations define a well posed initial value problem for the membrane shape and this `velocity' and so completely determinethe dynamics of the black hole. They may be viewed as governing the non-linear dynamics of the light quasi normal modes of Emparan, Suzuki and Tanabe.Comment: The main results emphasised better, The presentation of the quasinormal modes improved for clarity and typos correcte

Coral reef research in India: A Bibliometric analysis (Part-I)

Part-I of this paper attemps to evaluate the coral reef research in India using Bibliographic tools for the period 1900-2000. The data has been extracted from "Bibliography on Indian coral reefs". It highlights research productivity by subjects, domains, institutions (Research and Academic) etc. The study examines authorship pattern, productivity on individual scientists and also identified the various countries - participation. It analyzes the forms of communication, journals productivity and identified criteria for selection of the core journals for library. Suggested to create a database on coral reefs and to develop marine science at national level that would facilitate easy use of all categories of people

E-learning: A new way of Library and Information Science Education through Distance Mode

This study explored that the e-learning mechanism is required to provide for quality of Library and Information Science education at university level through the distance learning. This paper is divided into three sections. The first section deals with the LIS education in distance mode. Second section examines the developments of E-learning and LIS education in India. Third Section spells out the universities are forced to face the following major challenges to adopt e-learning mechanisms, which are to design LIS programmes to fit into the e-learning environment, to provide quality education, the teachers aswellas students are to be trained the information technology advancement, to enhance LIS education e-learning consortium, collaboration, quality assurance with accreditation and cost effective were discussed in details to strengthening the LIS education

Detection of Reliable Software Using SPRT on Interval Domain Data

In Classical Hypothesis testing volumes of data is to be collected and then the conclusions are drawn which may take more time. But, Sequential Analysis of statistical science could be adopted in order to decide upon the reliable / unreliable of the developed software very quickly. The procedure adopted for this is, Sequential Probability Ratio Test (SPRT). In the present paper we proposed the performance of SPRT on Interval domain data using Weibull model and analyzed the results by applying on 5 data sets. The parameters are estimated using Maximum Likelihood Estimatio

Tehnička svojstva zrna pirinča

Engineering properties of rice is essential for designing of storage bin. The physical properties of rice (ADT-43) namely, size, shape, thousand grains mass, aspect ratio, surface area, volume, bulk density, true density and porosity at moisture content ranging from 11.55 to 26.84% (db) were determined using standard techniques for development of ozone based storage bin. In this case, thousand grains mass, surface area and volume increased from 10.70 to 14.59 g, 14.58 to 16.94 mm2 and 3.78 to 4.76 mm3, respectively, with an increase in moisture content from 11.55 to 26.84% (db). Geometric mean diameter, sphericity, aspect ratio, true density and porosity increased from 2.30 to 2.48 mm, 0.45 to 0.46, 33.10 to 34.66%, 961.89 to 975.24 kg·m-3 and 26.97 to 29.66%, respectively, with an increase in moisture content from 11.55 to 26.84% (db). These properties are very essential for designing of different parts of ozone based storage bin.Tehnička svojstva pirinča su osnova za projektovanje skladišnog rezervoara. Sledeća svojstva pirinča (ADT-43): dimenzije, oblik, masa hiljadu zrna, površina, zapremina, gustina mase, stvarna gustina i poroznost, pri vlažnosti od 11.55 do 26.84% (db), određivane su standardnim tehnikama za razvoj ozonskog skladišnog rezervoara. U ovom slučaju, masa hiljadu zrna, površina i zapremina porasli su sa 10.70 na 14.59 g, 14.58 na 16.94 mm2 i 3.78 na 4.76 mm3, redom, sa povećanjem sadržaja vlage sa 11.55 na 26.84% (db). Geometrijski srednji prečnik, sveričnost, stvarna gustina i poroznost su se povećali sa 2.30 na 2.48 mm, 0.45 na 0.46, 33.10 na 34.66%, 961.89 na 975.24 kg·m-3 i 26.97 na 29.66%, redom, sa povećanjem sadržaja vlage sa 11.55 na 26.84% (db). Ova svojstva su osnov za konstruisanje različitih delova ozonskog skladišnog rezervoara

SYNTHESIS, ANTICANCER ACTIVITY, MOLECULAR DOCKING, AND ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION TOXICITY STUDIES OF NOVEL BENZOTHIAZINES

ABSTRACTObjective: A series of benzothiazine compounds were studied for absorption, distribution, metabolism, and excretion (ADME) properties to assestheir drug-like properties. Compounds 1-10 with favorable ADME properties were selected for molecular docking studies as PIM1 kinase inhibitors.Methods: Synthesis of compound 1 and 7 by conventional heating and characterized by various methods. Molecular docking carried out using Glidesoftware; ADME toxicity predicted using QuickPro.Results: Compound 1 showed a Glide score of −7.622 kcal/mol with good hydrophobic and hydrophilic interactions with PIM1 kinase proteins andappears to be more potent. Structure-activity relationship study was made among the 10 compounds, and a basic template was arrived at. An analysisof the structure - Affinity relationships suggested that the substituent at position three is important in influencing affinity.Conclusion: Compounds with an alkyl spacer between the carboxyl group and the core benzothiazine ring are required for binding of the compoundswith the PIM1 kinase. It was further confirmed by its in vitro anticancer activity of compound 1 against K562 cell lines by 3-(4, 5dimethythiazol-2yl)-2,5-diphenyltetrazoliumbromideassaybyexhibitingan IC50 value of 36.82 μg/ml.Keywords: Benzothiazine, Molecular docking, Absorption; distribution; metabolism; and excretion properties, In vitro anticancer activity

The effect of nutritional status on the response to highly active antiretroviral therapy in human immunodeficiency virus-infected children at regional antiretroviral therapy centre in Northern India

Background: Effect of highly active antiretroviral therapy (HAART) on growth in children is well established but influence of prior nutritional status on the response to HAART is not well known. Objective: To determine the influence of prior nutritional status on the response to HAART in terms of growth and CD4 counts. Methods: It was a retrospective record review based study conducted at a regional ART centre at a tertiary care, teaching hospital in Northern India. Human immunodeficiency virus (HIV) positive children who were naïve to antiretroviral therapy and were initiated on treatment from January 2006 to December 2007 were included in this study. Age, weight, height and CD4 cell counts were recorded at the initiation of HAART and after 24 months of therapy. Data was analyzed using paired t-tests within the groups, Chi-square tests, and one-way analysis of variance. Results: Seventy-nine HIV positive children were included in the study. At baseline, 29% of children were normal weight, 27% moderately underweight and 44% severely underweight with mean CD4 counts 243.30±178.50, 282.95±173.69 and 215.11±85.71 respectively. After 24 months of HAART, mean CD4 cell counts as well as weight for age z scores increased significantly in all 3 groups with mean CD4 counts being 913.61±401.46, 931.24±363.54 and 775.31±424.43 respectively in the groups. There were no significant differences in CD4 counts in the groups both pre and post ART. Conclusion: Underlying malnutrition does not adversely affect growth and immunologic response (increase in CD4 count) to HAART in HIV-infected children