1,183 research outputs found
Addressing the Safety and Criminal Exploitation of Vulnerable Young People: Before, During and After COVID-19 and Lockdown
This chapter is discussing the intersection of what is arguably an epidemic, and a pandemic, both of which can be fatal. In recent years there has been an epidemic in youth violence and crime, particularly in East London, and in the London Borough of Newham, where knife crime cases and youth knife injuries in particular have been consistently higher than comparator boroughs and London as a whole between 2013 and 2017. The chapter discusses in some detail the pre-pandemic Newham Keeping Safe (hereafter NKS) intervention aimed at vulnerable teenagers, proposing how this type of intervention could be adapted to the changing conditions of COVID-19 restrictions, and exploring the broader psychosocial implications for future interventions that aim to reduce the criminal exploitation of vulnerable young people, as we ‘open up’, or, at least, travel through new sets of changing conditions and restrictions. Such an endeavour requires that we reflect on what future levels of social distancing combined with more digital connections and practices could mean. Future interventions, we argue, need to include a reflection on the complex needs of children and families, and fathom the impact of interventions and their future post-COVID-19
EFFECT OF THE LOCATION OF THE FOOT IMPACT POINT ON BALL VELOCITY IN A SOCCER PENALTY KICK
The aim of this study was to identify the impact point on the foot that maximizes ball velocity in a soccer instep penalty kick. One male player performed 23 maximum-effort penalty kicks using a wide range of impact points along the length of his foot. The kicks were recorded by a video camera at 100 Hz and a biomechanical analysis was conducted to obtain measures of impact point, ball projection velocity, and kinematics of the kicking leg. We found that ball velocity was insensitive to the location of the impact point (at least for positions between the ankle joint and the base of the toes). This result suggests that players should consider other factors (such as shot accuracy, shot reliability, and foot comfort) when selecting the impact point
Comment on "Limited temporal variability of arsenic concentrations in 20 wells monitored for 3 years in Araihazar, Bangladesh"
Understanding Cheating: From the University Classroom to the Workplace
Cheating is defined as taking information, credit, or reward that one neither deserves nor did the work to achieve. Cheating behavior is often seen as a driver behind many of our current economic problems and the temptation to cheat has been associated with our downward slide in business practice for the past two decades. For example, the current housing crisis has been explained in part as banks cheating in terms of qualifying people for loans. Additionally, current headlines focus on legislators and Wall Street analysts who cheat investors by unfairly taking advantage of inside information not publicly available to others in the market. Cheating defeats fairness of competition and undermines the basis of business integrity. Writers in the business press are expressing concern over the widespread levels of ‘cheating’ among business executives. Enron, HealthSouth, and Tyco, all cheated shareholders in order to pad the pockets of their corporate executives. Some of the smartest and best business minds have fallen subject to the temptation to cheat and the result has been some of the most wideranging financial regulation in our history. The Sarbanes-Oxley and Dodd-Frank Acts were enacted in reaction to the perceived prevalence of cheating by business managers. The controversial new Consumer Financial Protection Bureau is yet another attempt to address this problem. Classroom teachers are also experiencing a growing concern over what seems to be ever increasing levels of cheating among students. Students cheat for a variety of reasons including a felt pressure to maintain good grades and because they perceive many opportunities to cheat but few real penalties for getting caught. Instructor behavior may unwittingly exacerbate the problem by giving unclear or arbitrary assignments that create a climate for cheating when students view the benefits of figuring out and completing the assignment honestly to be minimal at best. The problem of classroom cheating is that students are likely to carry the behaviors they learn in the classroom into the workplace. It is this prospect that leads us to examine the nature of classroom cheating as a precursor to what might happen in actual business settings. It is likely that many of us have cheated at something or in some way, however unimportant, in our lives. We may have taken advantage of unsuspecting others in sports or play and the amount of harm done is probably very little and accepted as part of the interaction. But when the stakes get higher and include academic or business integrity and the validity of a grade or financial statement are at stake, then cheating has significant potential consequences, and needs to be both understood and managed
A groundwater-planning toolkit for the main Karoo basin: Identifying and quantifying groundwater-development options incorporating the concept of wellfield yields and aquifer firm yields
This paper provides an overview of groundwater-planning tools that were developed during a Water Research Commission project that was initiated due to the need to place the significant knowledge on groundwater of the Karoo Basin within the realms of water resource planning. In essence, the project aimed to identify favourable areas of groundwater potential forbulk municipal water supplies, to provide a method to quantify them, and to package the information so that it is assessable for planning purposes. In identifying favourable groundwater areas, the focus turned to developing a detailed transmissivity map of the Main Karoo Basin. In order to present yields in an accessible manner to water-supply planners, the same concept used in surface-water resource assessments and dam or reservoir design were adapted and applied to groundwater. Two methods were developed, namely the Aquifer Assured Yield Model and the Aquifer Firm Yield Model (the latter of which was developed into a software package together with the other products). The Aquifer Firm Yield Model provides the historical firm yield and uses historical monthly rainfall data together with recharge, evapotranspiration and baseflow to determine aquifer storage in any given month. The firm yield can be considered to define the upper limit of the groundwater resource. In order to establish possible wellfield yields, the C-J Wellfield Model (based on the  Cooper-Jacob approximation of the Theis groundwater-flow equation) was developed whereby borehole spacing can be optimised after inputtingestimated transmissivity values from the transmissivity map. To aid the planning process, groundwater-quality maps were produced together with the Wellfield Cost Model which provides an easy way to obtain first-order cost estimates of the wellfield options. This paper briefly describes these ‘tools’ that were produced and provides slightly more detail on how thetransmissivity maps were developed
Natural organic matter in sedimentary basins and its relation to arsenic in anoxic ground water: the example of West Bengal and its worldwide implications
In order to investigate the mechanism of As release to anoxic ground water in alluvial aquifers, the authors sampled ground waters from 3 piezometer nests, 79 shallow (80 m) wells, in an area 750 m by 450 m, just north of Barasat, near Kolkata (Calcutta), in southern West Bengal. High concentrations of As (200-1180 mug L-1) are accompanied by high concentrations of Fe (3-13.7 mgL(-1)) and PO4 (1-6.5 mg L-1). Ground water that is rich in Mn (1-5.3 mg L-1) contains <50 mug L-1 of As. The composition of shallow ground water varies at the 100-m scale laterally and the metre-scale vertically, with vertical gradients in As concentration reaching 200 mug L-1 m(-1). The As is supplied by reductive dissolution of FeOOH and release of the sorbed As to solution. The process is driven by natural organic matter in peaty strata both within the aquifer sands and in the overlying confining unit. In well waters, thermotolerant coliforms, a proxy for faecal contamination, are not present in high numbers (<10 cfu/100 ml in 85% of wells) showing that faecally-derived organic matter does not enter the aquifer, does not drive reduction of FeOOH, and so does not release As to ground water.Arsenic concentrations are high (much greater than50 mug L-1) where reduction of FeOOH is complete and its entire load of sorbed As is released to solution, at which point the aquifer sediments become grey in colour as FeOOH vanishes. Where reduction is incomplete, the sediments are brown in colour and resorption of As to residual FeOOH keeps As concentrations below 10 mug L-1 in the presence of dissolved Fe. Sorbed As released by reduction of Mn oxides does not increase As in ground water because the As resorbs to FeOOH. High concentrations of As are common in alluvial aquifers of the Bengal Basin arise because Himalayan erosion supplies immature sediments, with low surface-loadings of FeOOH on mineral grains, to a depositional environment that is rich in organic mater so that complete reduction of FeOOH is common. (C) 2004 Published by Elsevier Ltd
A genome scale metabolic network for rice and accompanying analysis of tryptophan, auxin and serotonin biosynthesis regulation under biotic stress
Background
Functional annotations of large plant genome projects mostly provide information on gene function and gene families based on the presence of protein domains and gene homology, but not necessarily in association with gene expression or metabolic and regulatory networks. These additional annotations are necessary to understand the physiology, development and adaptation of a plant and its interaction with the environment.
Results
RiceCyc is a metabolic pathway networks database for rice. It is a snapshot of the substrates, metabolites, enzymes, reactions and pathways of primary and intermediary metabolism in rice. RiceCyc version 3.3 features 316 pathways and 6,643 peptide-coding genes mapped to 2,103 enzyme-catalyzed and 87 protein-mediated transport reactions. The initial functional annotations of rice genes with InterPro, Gene Ontology, MetaCyc, and Enzyme Commission (EC) numbers were enriched with annotations provided by KEGG and Gramene databases. The pathway inferences and the network diagrams were first predicted based on MetaCyc reference networks and plant pathways from the Plant Metabolic Network, using the Pathologic module of Pathway Tools. This was enriched by manually adding metabolic pathways and gene functions specifically reported for rice. The RiceCyc database is hierarchically browsable from pathway diagrams to the associated genes, metabolites and chemical structures. Through the integrated tool OMICs Viewer, users can upload transcriptomic, proteomic and metabolomic data to visualize expression patterns in a virtual cell. RiceCyc, along with additional species-specific pathway databases hosted in the Gramene project, facilitates comparative pathway analysis.
Conclusions
Here we describe the RiceCyc network development and discuss its contribution to rice genome annotations. As a case study to demonstrate the use of RiceCyc network as a discovery environment we carried out an integrated bioinformatic analysis of rice metabolic genes that are differentially regulated under diurnal photoperiod and biotic stress treatments. The analysis of publicly available rice transcriptome datasets led to the hypothesis that the complete tryptophan biosynthesis and its dependent metabolic pathways including serotonin biosynthesis are induced by taxonomically diverse pathogens while also being under diurnal regulation. The RiceCyc database is available online for free access at http://www.gramene.org/pathway
The public health significance of latrines discharging to groundwater used for drinking.
Faecal contamination of groundwater from pit latrines is widely perceived as a major threat to the safety of drinking water for several billion people in rural and peri-urban areas worldwide. On the floodplains of the Ganges-Brahmaputra-Meghna delta in Bangladesh, we constructed latrines and monitored piezometer nests monthly for two years. We detected faecal coliforms (FC) in 3.3-23.3% of samples at four sites. We differentiate a near-field, characterised by high concentrations and frequent, persistent and contiguous contamination in all directions, and a far-field characterised by rare, impersistent, discontinuous low-level detections in variable directions. Far-field FC concentrations at four sites exceeded 0 and 10 cfu/100 ml in 2.4-9.6% and 0.2-2.3% of sampling events respectively. The lesser contamination of in-situ groundwater compared to water at the point-of-collection from domestic wells, which itself is less contaminated than at the point-of-consumption, demonstrates the importance of recontamination in the well-pump system. We present a conceptual model comprising four sub-pathways: the latrine-aquifer interface (near-field); groundwater flowing from latrine to well (far-field); the well-pump system; and post-collection handling and storage. Applying a hypothetical dose-response model suggests that 1-2% of the diarrhoeal disease burden from drinking water is derived from the aquifer, 29% from the well-pump system, and 70% from post-collection handling. The important implications are (i) that leakage from pit latrines is a minor contributor to faecal contamination of drinking water in alluvial-deltaic terrains; (ii) fears of increased groundwater pollution should not constrain expanding latrine coverage, and (iii) that more attention should be given to reducing contamination around the well-head
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