4 research outputs found
A randomised controlled trial evaluating a rehabilitation complex intervention for patients following intensive care discharge: the RECOVER study
- Author
- Publication venue
- BMJ Publishing Group
- Publication date
- 01/01/2012
- Field of study
Introduction: Patients who survive an intensive care unit admission frequently suffer physical and psychological morbidity for many months after discharge. Current rehabilitation pathways are often fragmented and little is known about the optimum method of promoting recovery. Many patients suffer reduced quality of life.Methods and analysis: The authors plan a multicentre randomised parallel group complex intervention trial with concealment of group allocation from outcome assessors. Patients who required more than 48 h of mechanical ventilation and are deemed fit for intensive care unit discharge will be eligible. Patients with primary neurological diagnoses will be excluded. Participants will be randomised into one of the two groups: the intervention group will receive standard ward-based care delivered by the NHS service with additional treatment by a specifically trained generic rehabilitation assistant during ward stay and via telephone contact after hospital discharge and the control group will receive standard ward-based care delivered by the current NHS service. The intervention group will also receive additional information about their critical illness and access to a critical care physician. The total duration of the intervention will be from randomisation to 3 months postrandomisation. The total duration of follow-up will be 12 months from randomisation for both groups. The primary outcome will be the Rivermead Mobility Index at 3 months. Secondary outcomes will include measures of physical and psychological morbidity and function, quality of lifeand survival over a 12-month period. A health economic evaluation will also be undertaken. Groups will be compared in relation to primary and secondary outcomes; quantitative analyses will be supplemented by focus groups with patients, carers and healthcare workers.Ethics and dissemination: Consent will be obtained from patients and relatives according to patient capacity. Data will be analysed accordingto a predefined analysis plan
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016
- Author
- Aarts Craig
- Abdallah Rehab
- Abdul-Alim Siddiq
- Abolhalaj Milad
- Abtin Fereidoun
- Acheson Anupama
- Acquavella Nicolas
- Adams Gregory P.
- Adams Katherine
- Adams Sharon
- Adamus Tomasz
- Adekandi Madhukara
- Adurthi Sreenivas
- Adusumilli Prasad S.
- Aeffner Famke
- Afentoulis Michael
- Ager Casey
- Aggouraki Despoina
- Agrawal Rajendra
- Agrawal Sudhir
- Agrawal Swati
- Ahlers Christoph Matthias
- Ahmed Nabil
- Ahn Myung Ju
- Ahr Katya
- Ai Midan
- Aiba Rachida-Siham Bel
- Aisner Joseph
- Albertini Mark R.
- Albiges Laurence
- Albright Andrew
- Algazi Alain
- Ali Siraj
- Alicea Candido
- Allen Natalie
- Allersdorfer Andrea
- Alva Ajjai
- Amado Rafael
- Amaria Rodabe
- Ameratunga Malaka
- Amin Asim
- Amor Amira Ben
- Amrhein John
- Anagnostou Valsamo
- Andersen Rikke
- André Thierry
- Andtbacka Robert H. I.
- Angela Omilian
- Angell Helen K.
- Annels Nicola
- Annunziata Christina M.
- Ansa-Addo Ephraim A
- Ansari Tameem
- Antilla Marjukka
- Antonarakis Emmanuel S.
- Aoki Rhonda
- Armand Philippe
- Armstrong Adam
- Arora Kshitij
- Arreaza Gladys
- Ascierto Paolo A.
- Ashworth-Sharpe Julia
- Askmyr David
- Asmellash Senait
- Assadipour Yasmine
- Assenmacher Mario
- Athelogou Maria
- Atkins Michael B.
- Attaf Meriem
- Au Gough
- Au-Young Janice
- Avery Kendra N.
- Ayers Mark
- Azimi Vahid
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- Backert Linus
- Backes Floor J.
- Bagg Eleanor A. L.
- Bahjat Keith
- Bajorin Dean
- Bakker Lex
- Balakumaran Arun
- Ballesteros-Merino Carmen
- Bander Neil
- Bang Yung-Jue
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- Baratelli Felicita E.
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- Bergamaschi Cristina
- Berger Frank
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- Bernstein Donna
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- Wydro Mateusz
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- Yigitsoy Mehmet
- Yimer Habte
- Yonemitsu Yoshikazu
- Yoshino Takayuki
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- Yu Wendy
- Yu Xuezhong
- Yu Zhiya
- Yusko Erik
- Zacharakis Nikolaos
- Zaharoff David
- Zamarin Dmitriy
- Zang Xingxing
- Zanhow Cynthia
- Zappasodi Roberta
- Zarour Hassane
- Zavadova Eva
- Zehn Dietmar
- Zeng Gang
- Zeng Xue
- Zha Yuanyuan
- Zhang Bingqing
- Zhang Congcong
- Zhang Hongjun
- Zhang Hua
- Zhang Hui
- Zhang Jian
- Zhang Jinyu
- Zhang Liping
- Zhang Maggie
- Zhang Wenjun
- Zhang Xiaonan
- Zhang Yayan
- Zhao Fei
- Zhao Xingli
- Zhao Zeguo
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- Zhu Baogong
- Zhu Cheng
- Zhu Yifei
- Zi Tong
- Zimarino Carlo
- Zinzani Pier Luigi
- Zoon Kathryn C.
- Zuleger Cindy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
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- Allison K.S.
- Allos R.
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- Zöllner S.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
- Author
- Aarts Craig
- Abdallah Rehab
- Abdul-Alim Siddiq
- Abolhalaj Milad
- Abtin Fereidoun
- Acheson Anupama
- Acquavella Nicolas
- Adams Gregory P
- Adams Katherine
- Adams Sharon
- Adamus Tomasz
- Adekandi Madhukara
- Adurthi Sreenivas
- Adusumilli Prasad S
- Aeffner Famke
- Afentoulis Michael
- Ager Casey
- Aggouraki Despoina
- Agrawal Rajendra
- Agrawal Sudhir
- Agrawal Swati
- Ahlers Christoph M
- Ahmed Nabil
- Ahn Myung J
- Ahr Katya
- Ai Midan
- Aiba Rachida-Siham B
- Aisner Joseph
- Albertini Mark R
- Albertini Mark R
- Albiges Laurence
- Albright Andrew
- Albright Andrew
- Algazi Alain
- Ali Siraj
- Alicea Candido
- Allen Natalie
- Allersdorfer Andrea
- Alva Ajjai
- Amado Rafael
- Amaria Rodabe
- Ameratunga Malaka
- Amin Asim
- Amor Amira B
- Amrhein John
- Anagnostou Valsamo
- Andersen Rikke
- Andersen Rikke
- André Thierry
- Andtbacka Robert H I
- Angela Omilian
- Angell Helen K
- Annels Nicola
- Annunziata Christina M
- Ansa-Addo Ephraim A
- Ansari Tameem
- Antilla Marjukka
- Antonarakis Emmanuel S
- Antonarakis Emmanuel S
- Aoki Rhonda
- Armand Philippe
- Armand Philippe
- Armstrong Adam
- Arora Kshitij
- Arreaza Gladys
- Ascierto Paolo A
- Ashworth-Sharpe Julia
- Askmyr David
- Asmellash Senait
- Assadipour Yasmine
- Assenmacher Mario
- Athelogou Maria
- Atkins Michael B
- Atkins Michael B
- Atkins Michael B
- Attaf Meriem
- Au Gough
- Au-Young Janice
- Avery Kendra N
- Avery Kendra N
- Ayers Mark
- Ayers Mark
- Ayers Mark
- Azimi Vahid
- Aznar M. A
- Backert Linus
- Backes Floor J
- Bagg Eleanor A L
- Bahjat Keith
- Bajorin Dean
- Bakker Lex
- Balakumaran Arun
- Balakumaran Arun
- Balakumaran Arun
- Ballesteros-Merino Carmen
- Ballesteros-Merino Carmen
- Ballesteros-Merino Carmen
- Bander Neil
- Bang Yung-Jue
- Bannerji Rajat
- Baratelli Felicita E
- Barbee Susannah D
- Barlesi Fabrice
- Barrett Carl
- Barrett David
- Barth Carola
- Bartkowiak Todd
- Bartlett Nancy
- Basher Fahmin
- Bassett Roland
- Bassett Roland
- Basu Samik
- Bath Natalie
- Batista Luciana
- Bauer Todd
- Bauer Todd M
- Bauer Todd W
- Baughman Jan E
- Bayle J. H
- Baylin Stephen
- Beechem Joseph
- Beechem Joseph
- Beechem Joseph
- Beeson Craig
- Bellmunt Joaquim
- Bellmunt Joaquim
- Bellovin David I
- Beltran Nancy
- Bendell Johanna
- Bender James
- Bender James
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- Bennett Alan D
- Bennett Mark K
- Bergamaschi Cristina
- Berger Frank
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- Bergeron Derek
- Berglund Anders
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- Bernatchez Chantale
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- Bernstein Donna
- Bessell Catherine A
- Betts Gareth
- Beyer Sophie
- Bhanot Gyan
- Bhardwaj Nina
- Bhardwaj Nina
- Bhardwaj Nina
- Bhardwaj Rukmini
- Bhatia Shailender
- Bhatia Shailender
- Bhaumik Srabani
- Bianchi Valentina
- Bielamowicz Kevin
- Bieniarz Christopher
- Bifulco Carlo
- Bifulco Carlo
- Bifulco Carlo
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- Billingsley James M
- Binder-Scholl Gwendolyn
- Binder-Scholl Gwendolyn
- Binnig Gerd
- Birditt Brian
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- Black Joshua C
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- Black Mary
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- Blackmon Shauna
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- Blaskovich Michelle A
- Blaskovich Michelle A
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- Blazar Bruce R
- Blitzer Grace
- Bonzon Christine
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- Borch Troels H
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- Borges Luis
- Borkar Rohan N
- Bornschlegl Svetlana
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- Bosch Marnix
- Bose Nandita
- Bossen Bolette
- Bot Adrian
- Botti Gerardo
- Boudadi Karim
- Boussiotis Vassiliki A
- Brahmer Julie
- Bramson Jonathan
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- Cao Alexander
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- Caron Christine
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- Carpio Cecilia
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- Carvajal-Hausdorf Daniel
- Caspell Richard
- Caux Christophe
- Cecchi Fabiola
- Celis Esteban
- Cerkovnik Logan
- Cervera-Carrascón Víctor
- Chacon Jessica
- Chagin Karen
- Chakraborty Paramita
- Champagne Monique
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- Chao Mark
- Chatterjee Shilpak
- Chaudhri Apoorvi
- Cheever Martin
- Chen Amanda
- Chen Hui
- Chen Jie Q
- Chen Lawrence
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- Chen Xiufen
- Cheng Jonathan
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- Chikina Maria
- Chin Renee
- Chinnasamy Harshini
- Chlosta Sabine
- Chlosta Sabine
- Choi Minsig
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- Christian Beth
- Chu Liz
- Chu Seung
- Chu Seung
- Chunduru Srinivas
- Clark Joseph I
- Clayburgh Daniel R
- Clement Amanda
- Clements Erin
- Cohen Lewis
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- Colevas A D
- Collins Jennifer
- Colyer Duncan
- Cong Mei
- Conlin Alison
- Conlon Kevin
- Conrad Valerie
- Conroy Jeff
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- Copeland Larry
- Copploa Domenico
- Cordes Lisa
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- Cortina Luis
- Coussens Lisa M
- Couto Joseph
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- Crabill George
- Cristescu Razvan
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- Crocker Andrea
- Cui Weiguo
- Culp William
- Cumberbatch Kerwin
- Curran Michael
- Curti Brendan
- Curti Brendan
- Curti Brendan
- Curti Brendan
- Dadey Rebekah
- Daenthanasanmak Anusara
- Dai Zhimin
- Damare Sherri
- Dammassa Ernesta
- Danaher Patrick
- Danaher Patrick
- Danforth David
- Daud Adil
- Davar Diwakar
- Davenport Anna
- David Larry
- Davies Bronwyn
- Davies Michael A
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- Davis Tom
- De Bono Johann
- De Macedo Mariana P
- de Oliveira Moacyr R
- De Santis Maria
- de Wit Ronald
- Deacon Donna H
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- Deeds Michael
- Del Pilar Estevez Diz Maria
- Delcommenne Marc
- Delgoffe Greg M
- Delgoffe Greg M
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- Delismon Judy
- Denisova Galina
- Dennis Lucas
- Dennis Lucas
- Deol Abhinav
- Derakhshandeh Roshanak
- DeRenzo Christopher
- Desai Jayesh
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- Deshpande Amit
- Deshpande Amit
- Deshpande Vikram
- Desjarlais John
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- Deveraux Quinn
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- Devlin Sean
- Dey Chaitali
- Dhudashia Amit
- di Pietro Alessandra
- Diab Adi
- Diaz Luis A
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- Ding Naiqing
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- Disis Mary L
- Dobson Jason R
- Docta Roslin
- Dolstra Harry
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- Donda Alena
- Donia Marco
- Donia Marco
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- Donovan Michael J
- doo Chang Young
- Doody Jacqueline
- Dotti Gianpietro
- Dougherty Janna
- Downing Sean
- Dragnev Konstanin
- Drake Charles G
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- Dranoff Glenn
- Draper Lindsey M
- Drechsel Katharina
- Dreicer Robert
- Dubay Christopher
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- Dubois Sigrid
- Duhen Rebekka
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- Dummer Reinhard
- Dunaway Dwayne
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- Dundr Pavel
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- Dutour Aurélie
- Dyson Gregory
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- Essand Magnus
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- Fakhrejahani Farhad
- Falchook Gerald
- Fan Aaron
- Fan Frank
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- Tsai Katy
- Tsang Kwong
- Tsang Kwong
- Tsao Tsu-Shuen
- Tsourkas Andrew
- Tsujikawa Takahiro
- Tufman Amanda
- Tumeh Paul
- Tumeh Paul C
- Turcotte Simon
- Tykodi Scott
- Uemura Marc
- Uger Robert
- Uhlik Mark
- Uhlin Michael
- Uhlin Michael
- Urba Walter
- Urba Walter
- Urba Walter
- Urba Walter
- Uribe Diana
- Vaishampayan Ulka
- Vaishampayan Ulka
- Valsesia-Wittmann Sandrine
- van den Brink Marcel R M
- Van den Eynde Marc
- van Hoef Vincent
- van Loo Pieter F
- Vandeven Natalie
- Varadarajan Navin
- Varadhachary Gauri R
- Vasaturo Angela
- Vaske Charles
- Vasselli James
- Veerapathran Anandaraman
- Velcheti Vamsidhar
- Velcheti Vamsidhar
- Veninga Henrike
- Vetsika E-K
- Vignali Dario
- Villabona Lisa
- Villalobos Victor M
- Villarroel Patricio P
- Viller Natasja N
- Vitale Laura A
- Vitale Laura A
- Vocka Michal
- Volkmer Jens-Peter
- Voss Martin
- Vuyyuru Raja
- Wagner Joel P
- Wakefield Jessica
- Wakelee Heather A
- Waldmann Anja
- Waldmann Thomas
- Wallace William D
- Waller Edmund K
- Walser Tonya C
- Walsh William
- Wan Ee
- Wan Ee
- Wan Ee
- Wang Chichung
- Wang Chun-Wei
- Wang Daqing
- Wang Gerald
- Wang Hao
- Wang Judy S
- Wang Lai
- Wang Ziming
- Wang Ziming
- Wardell Seth
- Wardell Seth
- Wargo Jennifer
- Wargo Jennifer
- Warren Sarah
- Warren Sarah
- Warren Sarah
- Wassman Karl
- Watkins Simon
- Webb Tonya J
- Weber James
- Weber Jeffrey
- Weber Jeffrey
- Weber Jeffrey
- Weber Sharon
- Webster Philippa
- Wei Ziewn
- Weidlick Jeffrey
- Weigel Tracey
- Weinberg Andrew
- Weinberg Andrew
- Weissbrich Bianca
- Weissman Irving L
- Wels Winfried S
- Wennerberg Erik
- Wenthe Jessica
- Westergaard Marie C W
- Westergaard Marie C W
- Whetstone Ryan
- White Andrew M
- White Andrew M
- White Eileen
- Whiting Sam
- Widger Jenifer
- Wiedenmann Alexander
- Wiedermann Guy
- Wiegand Volker
- Wiener Doris
- Wigginton Jon
- William Loging
- Williams Jason B
- Williams LaTerrica C
- Winter Hauke
- Withers Sita
- Witjes J. A
- Witt Kristina
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfson Martin
- Wondyfraw Nebiyu
- Wong Philip
- Wong Ryan
- Woodman Scott
- Woods David
- Workman Creg
- Wu Catherine J
- Wu Haiyan
- Wu Haiyan
- Wu Jennifer
- Wunderlich John
- Wunderlich John
- Wydro Mateusz
- Xiao Christine
- Xiao Weihua
- Xin Gang
- Xu Hui
- Xue Allen
- Yamamoto Tori
- Yanagawa Jane
- Yang James
- Yang Jason
- Yang Richard
- Yearley Jennifer
- Yearley Jennifer
- Yee Andrew J
- Yee Cassian
- Yehuda Dina B
- Yigitsoy Mehmet
- Yimer Habte
- Yonemitsu Yoshikazu
- Yoshino Takayuki
- Yu Evan Y
- Yu Wendy
- Yu Xuezhong
- Yu Zhiya
- Yu Zhiya
- Yusko Erik
- Zacharakis Nikolaos
- Zaharoff David
- Zamarin Dmitriy
- Zang Xingxing
- Zanhow Cynthia
- Zappasodi Roberta
- Zarour Hassane
- Zavadova Eva
- Zehn Dietmar
- Zeng Gang
- Zeng Xue
- Zha Yuanyuan
- Zhang Bingqing
- Zhang Congcong
- Zhang Hongjun
- Zhang Hua
- Zhang Hui
- Zhang Jian
- Zhang Jinyu
- Zhang Liping
- Zhang Maggie
- Zhang Wenjun
- Zhang Xiaonan
- Zhang Yayan
- Zhang Yayan
- Zhao Fei
- Zhao Xingli
- Zhao Zeguo
- Zhong Shi
- Zhu Baogong
- Zhu Cheng
- Zhu Yifei
- Zi Tong
- Zi Tong
- Zimarino Carlo
- Zinzani Pier L
- Zinzani Pier L
- Zoon Kathryn C
- Zuleger Cindy
- Publication venue
- Publication date
- 27/03/2018
- Field of study