Thai marine fungal diversity

The marine fungal diversity of Thailand was investigated and 116 Ascomycota, 3 Basidiomycota, 28 anamorphic fungi, 7 Stramenopiles recorded, with 30 tentatively identified. These species have primarily been collected from driftwood and attached decayed wood of mangrove trees. The holotype number of 15 taxa is from Thailand and 33 are new records from the country

Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes <i>Perenniporia centrali-africana</i> and <i>Cerrena</i> sp. nov

Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,7-Dehydro-isodrimenediol (3) were isolated from P. centrali-africana. In parallel, the two new drimane-type sesquiterpene lactams 5 and 6 were isolated together with known isodrimenediol (4) from Cerrena sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities

Lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete <i>Ganoderma australe</i>

<p>A new lanostane triterpene (<b>1</b>), together with three known compounds (<b>2</b>–<b>4</b>), were isolated from cultivated fruiting bodies of the basidiomycete <i>Ganoderma australe</i>. The structure was elucidated on the basis of NMR spectroscopic and mass spectrometry data. The olefinic geometry of methyl australate (<b>2</b>) was revised from 20(22)<i>Z</i> to 20(22)<i>E</i>. These compounds (<b>1</b>–<b>4</b>) were different from the lanostanes isolated from mycelial cultures of the same strain source.</p

Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete <i>Ganoderma</i> sp. BCC 16642

Sixteen new lanostane triterpenoids (<b>1</b>–<b>16</b>), together with 26 known compounds (<b>17</b>–<b>42</b>), were isolated from cultures of the basidiomycete <i>Ganoderma</i> sp. BCC 16642. Antitubercular activities of these <i>Ganoderma</i> lanostanoids against <i>Mycobacterium tuberculosis</i> H37Ra were evaluated, and structure–activity relationships are proposed

Antitubercular Activity of Mycelium-Associated <i>Ganoderma</i> Lanostanoids

In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of <i>Ganoderma</i> species, three strains, <i>Ganoderma orbiforme</i> BCC 22325, <i>Ganoderma</i> sp. BCC 60695, and <i>Ganoderma australe</i> BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together with 35 known compounds, were isolated. Antitubercular activities of these mycelium-associated <i>Ganoderma</i> lanostanoids against <i>Mycobacterium tuberculosis</i> H37Ra were evaluated. Taken together with the assay data of previously isolated compounds, structure–activity relationships of the antitubercular activity are proposed. Most importantly, 3β- and 15α-acetoxy groups were shown to be critical for antimycobacterial activity. The most potent compound was (24<i>E</i>)-3β,15α-diacetoxylanosta-7,9­(11),24-trien-26-oic acid (<b>35</b>)