A study on outcome of pregnancy of unknown location

Background: Pregnancies of unknown location (PUL) are becoming more common as women presenting to early pregnancy assessment units when a pregnancy test comes positive but there is no evidence of an intrauterine pregnancy. The objective of the present retrospective study was to find out the outcome of women with pregnancy of unknown location presenting to a tertiary hospital in Northern Ireland.Methods: This retrospective analytic study used medical record data between July 2019 and December 2021 from the Altnagelvin Area Hospital of Northern Ireland. TVUS was considered to diagnose the PUL and thereafter beta-human chorionic gonadotrophin (β-hCG) level was monitored as per institutional protocol. Expectant management was carried out until the pregnancy outcome was finalised. Using Statistical package for social sciences (SPSS) version 26, all collected data were analysed using the multinomial logistic regression.Results: For the analysis among the 63 participants, 25.4% were primi gravida and 38.1% presented with 4-5 weeks of gestation. Pain abdomen and vaginal bleeding was represented by 20.6% and 52.4% respectively. Confirmed ectopic pregnancy was observed among 4.8% and was surgically managed. Also, persistent PUL was 7.9% and these cases were successfully managed by Methotrexate.Conclusions: The large proportion will be biochemical pregnancy or intrauterine pregnancies, with a tiny fraction of ectopic pregnancies. Early detection of ectopic pregnancy is most challenging part among the women presented with PUL category

A Review on Current Status of Blood Disorder: Thalassemia and its Treatment

The most prevalent hereditary monogenic disorders that claim millions of lives globally are thalassemic syndromes. A thalassemia is an inherited condition, at least one parent must carry the disease's gene. Perhaps a genetic mutation/ defective globin chain or the loss of specific important gene segments is the main cause. Thalassemic illnesses started to strain the healthcare systems of several nations worldwide. Management of thalassemia is now seen as a lifelong treatment that requires continuous monitoring. In this review, we seek to compile and analyze recent research on thalassemia diagnosis and treatment, including papers, studies, and clinical trials. We also intend to present a concise yet comprehensive study. A thalassemia is an inherited condition, at least one parent must carry the disease's gene. Perhaps a genetic mutation/ defective globin chain or the loss of specific important gene segments is the main cause

Calculations of energy levels, radiative transition parameters, hyperfine structure constants AJ - BJ, Landé gJ factors and isotope shifts for Sc XX using the MCDF-RCI method

Large scale calculations for the energy levels, transition rates, oscillator strengths, lifetimes, hyperfine interaction constants, Landé gJ factors, and isotope shift factors have been performed for 1s2 and 1snl (n=2−8andl≤n−1) levels of He-like Sc XX ion. The general-purpose relativistic atomic structure package (GRASP2018) based on the fully relativistic multiconfiguration Dirac–Fock (MCDF) method is used to carry out the calculations. The leading quantum electrodynamic corrections, Breit interaction and nuclear recoil effects are also included in the succeeding relativistic configuration interaction (RCI) calculations. The relativistic isotope shift (RIS4) programme is used to determine the mass and field shifts factors. Furthermore, the percentage uncertainty in the transition parameters and lifetimes is estimated. A detailed comparison of the present results with the corresponding values from the NIST database and other theoretical and experimental works, wherever available, has been done, and an excellent agreement is achieved. A large section of the results is reported for the first time in the present work

Extended Calculations of Atomic Structure Parameters for Na-like Ar, Kr and Xe Ions Using Relativistic MCDHF and MBPT Methods

In this study, comprehensive calculations of energies, hyperfine structure constants, Landé gJ factors and isotope shifts have been performed for the lowest 71 states of Na-like Ar7+, Kr25+ and Xe43+ ions. Radiative parameters viz., wavelengths, transition rates, oscillator strengths and lifetimes are estimated for the electric dipole E1 transitions among these levels. The states under consideration include 1s22s22p6nl for n = 3–9, l = 0–6, and the fully relativistic multiconfiguration Dirac–Hartree–Fock (MCDHF) method integrated in the latest version of the general-purpose relativistic atomic structure package (GRASP2018) is used for the calculations. The additional corrections, such as the Breit interaction and quantum electrodynamics effects are included in the relativistic configuration interaction calculations, and their effects on energies and other parameters are analysed. We examined the impact of including the core–core and core–valence correlations on level energies. Furthermore, to inspect the reliability of our MCDHF results, we performed another set of calculations using the many-body perturbation theory built into the Flexible Atomic Code (FAC). Moreover, we estimated the uncertainties in the computed lifetimes and transition parameters and assigned their accuracy class. A thorough comparison between the two obtained calculations and with the previous theoretical and experimental results, wherever available, is carried out and a good agreement is observed

Condylar degeneration in anterior open bite patients: A cone beam computed tomography study

Objectives: The purpose of this study was to investigate the prevalence of condylar degeneration in patients with anterior open bites (AOB). Study design: Cone beam computed tomography (CBCT) scans of 194 patients with AOB (108 with skeletal open bites and 86 with dental open bites) and 100 patients serving as controls were included in this retrospective study. Two oral and maxillofacial radiologists categorized each of the 588 condyles as normal, degenerative-active, or degenerative-repair. The χ2 analysis with Bonferroni adjustment was used to evaluate the relationship of condylar status (normal vs degenerative) to anterior open bites. Results: Of the 103 degenerative condyles, there were 59 in the group with skeletal open bites, 14 in the group with dental open bites, and 30 in the control group. Condylar degeneration occurred twice as frequently in patients with skeletal open bites as it did in the control group (P \u3c .0001). Conversely, a greater frequency of normal condyles was found in the group of patients with dental open bites (P = .0002). The group with skeletal open bites also showed a significantly higher frequency of bilateral degenerative condyles (P = .0001). The frequency of condylar degeneration did not differ significantly between female and male individuals. Conclusions: Degenerative condylar change was significantly more likely in patients with skeletal open bites and less likely in patients with dental open bites

tardis-sn/tardis: TARDIS v2023.10.20

<p>This release has been created automatically by the TARDIS continuous delivery pipeline.</p> <p>A complete list of changes for this release is available at <a href="https://github.com/tardis-sn/tardis/blob/master/CHANGELOG.md">CHANGELOG.md</a>.</p&gt

tardis-sn/tardis: TARDIS v2023.11.05

<p>This release has been created automatically by the TARDIS continuous delivery pipeline.</p> <p>A complete list of changes for this release is available at <a href="https://github.com/tardis-sn/tardis/blob/master/CHANGELOG.md">CHANGELOG.md</a>.</p&gt