2-Eth­oxy-5-methylbis[1,2,4]triazolo[1,5-a:4′,3′-c]quinazoline

The title compound, C13H12N6O, is a functionalized ditriazoloquinazoline with substituted eth­oxy and methyl groups attached at the 2-position of each triazole spacer. The fused-ring system is essentially planar [r.m.s. deviation = 0.016 (2) Å]. In the crystal, a weak C—H⋯N hydrogen bond connects the mol­ecules into a chain along [101]

2-Benz­yloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one

The title compound, C16H12N4O2, is a functionalized triazoloquinazoline with a substituted benz­yloxy group attached at the 2-position of a triazole spacer. The triazoloquinazoline fused-ring system is approximately planar (r.m.s. deviation = 0.016 Å) while the benzyl substituent is perpendicular to the ring system, making a dihedral angle of 65.29 (6)°. The phenyl ring of the benz­yloxy moiety is equally disordered over two sets of sites. A centrosymmetric N—H⋯N hydrogen bond connects mol­ecules into dimers

3-Benzyl-8-meth­oxy-2-sulfanyl­idene-1,2,3,4-tetra­hydro­quinazolin-4-one

The tetra­hydro­quinazole fused-ring system of the title compound, C16H14N2O2S, is roughly planar (r.m.s. deviation = 0.039 Å); the phenyl ring of the benzyl substituent is aligned at 78.1 (1)° with respect to the mean plane of the fused-ring system. In the crystal, two mol­ecules are linked by a pair of N—H⋯S hydrogen bonds about a center of inversion, generating a dimer

N-[2,4-Dioxo-3-aza­tricyclo­[7.3.1.05,13]trideca-1(13),5,7,9,11-pentaen-3-yl]thio­urea

In the two independent mol­ecules in the asymmetric unit of the title compound, C13H9N3O2S, the aza­tricyclo­trideca­penta­ene ring system is approximately planar with r.m.s. deviations of 0.022 and 0.033 Å. The urea unit connected to the fused rings is approximately perpendicular [dihedral angles = 82.4 (1) and 82.7 (1)°]. In the crystal, the mol­ecules associate by N—H⋯O hydrogen bonds, forming a chain running along the a axis. The crystal studied was a non-merohedral twin with a fractional contribution of 49.6 (1)% for the minor domain

3-(Prop-2-en-1-yl)-2-sulfanyl­idene-1,2,3,4-tetra­hydro­quinazolin-4-one

The tetra­hydro­quinazoline fused-ring system of the title compound, C11H10N2OS, is approximately planar (r.m.s. deviation = 0.019 Å). In the crystal, adjacent mol­ecules are linked by N—H⋯O hydrogen bonds, forming a chain running along the b axis

2-Phen­oxy-1,2,4-triazolo[1,5-a]quinazol­in-5(4H)-one

The triazoloquinazole ring system in the title compound, C15H10N4O2 is approximately planar (r.m.s. deviation = 0.035 Å). The phenyl ring of the phen­oxy substitutent is aligned at 59.3 (1)° with respect to this ring system. In the crystal, two mol­ecules are linked about a center of inversion by a pair of N—H⋯O hydrogen bonds, generating a dimer

2-Methyl­sulfanyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one

The non-H atoms of the title compound, C10H8N4OS, lie approximately in a common plane (r.m.s. deviation = 0.058 Å). In the crystal, two mol­ecules are linked across a center of inversion by a pair of N—H⋯N hydrogen bonds, forming a a dimer

5-Chloro-2-methyl­sulfonyl-1,2,4-triazolo[1,5-a]quinazoline

The triazoloquinazole fused-ring system of the title compound, C10H7ClN4O2S, is essentially planar (r.m.s. deviation = 0.009 Å). In the methyl­sulfonyl substituent, the two S—O bonds are of equal length [1.402 (2) Å]. In the crystal, adjacent mol­ecules inter­act weakly through Cl⋯N contacts [ca 3.197 (2) Å]

3-Benzyl-6-methyl-2-sulfanylidene-2,3-di­hydroquinazolin-4(1H)-one

In the title compound, C16H14N2OS, the quinazoline ring system is essentially planar, with a maximum deviation of 0.029 (3) Å. The dihedral angle between the quinazoline and benzene rings is 88.4 (2)°. In the crystal, adjacent mol­ecules are connected via pairs of N—H⋯S and C—H⋯O hydrogen bonds, which generate R 2 2(8) and R 2 2(10) graph-set motifs, respectively, resulting in a supra­molecular chain along the a axis

Chemical Composition, Antioxidant and Antibacterial Activities of Thymus broussonetii Boiss and Thymus capitatus (L.) Hoffmann and Link Essential Oils

Thymus capitatus and Thymus broussonnetii are two Moroccan endemic medicinal plants used traditionally by the local population. The present study aims to investigate their essential oil chemical composition, antioxidant and antibacterial activities. The chemical composition of the essential oils was determined using the GC-MS analysis, the antioxidant activity assessed using DPPH and FRAP methods while the antimicrobial activity was evaluated against nine bacteria species tested (Enterococcus faecalis, Serratia fonticola, Acinetobacter baumannii, Klebsiella oxytoca, sensitive Klebsiella pneumoniae, sensitive Escherichia coli, resistant Escherichia coli, resistant Staphylococcus aureus and Enterobacter aerogenes). The major identified compounds of T. capitatus essential oil where carvacrol (75%) and p-cymene (10.58%) while carvacrol (60.79%), thymol (12.9%), p-cymene (6.21%) and γ-terpinene (4.47%) are the main compounds in T. broussonnetii essential oil. The bioactivity of the essential oils of the two species of thyme was explained by their richness in oxygenated monoterpenes known for their great effectiveness with an IC50 of 3.48 ± 0.05 and 4.88 ± 0.04 μL/mL and EC50 of 0.12 ± 0.01 and 0.20 ± 0.02 μL/mL in the DPPH and FRAP assays, respectively, with an important antibacterial activity. These results encourage the use of these plants as a source of natural antioxidants, and antibacterial additives, to protect food from oxidative damage and to eliminate bacteria that are responsible for nosocomial infections