10 research outputs found

    Functional impairment of systemic scleroderma patients with digital ulcerations: Results from the DUO registry

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    A Permian andesitic tuff ring at Rožmitál (the Intra-Sudetic Basin, Czech Republic) : evolution from explosive to effusive and high-level intrusive activity

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    Mafic, monogenetic volcanism is increasingly recognized as a common manifestation of post-collisional volcanism in late Variscan, Permo-Carboniferous intramontane basins of Central Europe. Although identification of individual eruptive centres is not easy in these ancient successions, the Permian Rožmitál andesites in the Intra-Sudetic Basin (NE Bohemian Massif) provide an exceptionally detailed record of explosive, effusive and high-level intrusive activity. Based on field study and petrographic and geochemical data on pyroclastic and coherent rocks, the Rožmitál succession is interpreted as the proximal part of a tuff ring several hundred metres in diameter. Initial accumulation of pyroclastic fall and surge deposits occurred during phreatomagmatic eruptions, with transitions towards Strombolian eruptions. Gullies filled with reworked tephra document periods of erosion and redeposition. Andesitic blocky lavas capped the volcaniclastic succession. Invasion of lavas into unconsolidated sediments and emplacement of shallow-level intrusions in near-vent sections resulted in the formation of jigsaw- and randomly-textured peperites. Most geochemical differences between coherent andesites and pyroclastic rocks can be linked to incorporation of quartz-rich sediments during the explosive eruptive processes and to later cementation of the volcaniclastic deposits by dolomite. The Rožmitál tuff ring could have been one of several phreatomagmatic centres in a monogenetic volcanic field located on an alluvial plain

    Emplacement History of the Miocene Zebín Tuff Cone (Czech Republic) Revealed From Ground Geophysics, Anisotropy of Magnetic Susceptibility, Paleomagnetic, and 40

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    Abstract The Zebín Volcano, Czech Republic, is a quarried tuff cone that offers the opportunity to understand emplacement processes responsible for magma transport through a pyroclastic cone and magmatic processes involved in its development. A high‐resolution ground magnetometry survey, electrical resistivity tomography, and refraction seismic were conducted to supplement field mapping of the size, shape, and inner structure of the volcanic system. The Zebín Volcano yields normal polarity rocks, and the cone is underlain by a complex and branching magma feeder system with several diverging dikes. Samples were collected at 24 sites from feeder dikes and the main conduit for anisotropy of magnetic susceptibility and paleomagnetic analysis. Anisotropy of magnetic susceptibility results yield inferred magma flow directions indicating subhorizontal magma flow toward and away from the axial conduit as well as both upward and downward flow. Paleomagnetic data from all sites are normal polarity with statistically distinct remanence directions between some sites that indicate that significant time passed or deformation occurred during the growth of this volcanic system. 40Ar/39Ar isochron ages of groundmass provide emplacement ages of 18.38 ± 0.03 and 18.45 ± 0.03 Ma, whereas a weighted mean date of 18.52 ± 0.03 Ma for hornblende provides an eruption age. We argue that the Zebín Volcano evolved from a polyphase feeding system and through a complex feeder network. This detailed study shows that many monogenetic volcanoes deserve highly detailed study, as their subtleties can provide insight into broader crustal and magmatic environment during magmatism

    Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry

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    Objective. Digital ulcers (DUs) are frequent manifestations of systemic scleroderma (SSc). This study assessed functional limitations due to DUs among patients enrolled in the Digital Ulcer Outcome (DUO) Registry, an international, multicentre, observational registry of SSc patients with DU disease. Methods. Patients completed at enrolment a DU-specific functional assessment questionnaire with a 1-month recall period, measuring impairment in work and daily activities, and hours of help needed from others. Physician-reported clinical parameters were used to describe the population. For patients who completed at least part of the questionnaire, descriptive analyses were performed for overall results, and stratified by number of DUs at enrolment. Results. This study included 2327 patients who completed at least part of the questionnaire. For patients with 0, 1-2, and DUs at enrolment, mean overall work impairment during the prior month among employed/self-employed patients was 28\%, 42\%, and 48\%, respectively. Across all included patients, ability to perform daily activities was impaired on average by 35\%, 54\%, and 63\%, respectively. Patients required a mean of 2.0, 8.7, and 8.8 hours of paid help and 17.0, 35.9, and 63.7 hours of unpaid help, respectively, due to DUs in the prior month. Patients with DUs had more complications and medication use than patients with no DUs. Conclusion. With increasing number of DUs, SSc patients reported more impairment in work and daily activities and required more support from others
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