Analysis of Acoustic Emission Signals using WaveletTransformation Technique

Acoustic emission (AE) monitoring is carried out during proof pressure testing of pressurevessels to find the occurrence of any crack growth-related phenomenon. While carrying out AEmonitoring, it is often found that the background noise is very high. Along with the noise, thesignal includes various phenomena related to crack growth, rubbing of fasteners, leaks, etc. Dueto the presence of noise, it becomes difficult to identify signature of the original signals related to the above phenomenon. Through various filtering/ thresholding techniques, it was found that the original signals were getting filtered out along with noise. Wavelet transformation technique is found to be more appropriate to analyse the AE signals under such situations. Wavelet transformation technique is used to de-noise the AE data. The de-noised signal is classified to identify a signature based on the type of phenomena.Defence Science Journal, 2008, 58(4), pp.559-564, DOI:http://dx.doi.org/10.14429/dsj.58.167

Novel Approaches to Enhance Oral Bioavailability of Poorly Soluble Drugs

Oral administration is considered as major, convenient route among all other routes of delivery, owing to several benefits. But, the poor solubility or enzymatic/metabolic activity are the major concerns in developing a successful formulation. About 40% of approved drugs which are in the current market and 90% of new drug molecules in the developmental pipeline are hydrophobic in nature. The challenge to formulate insoluble drugs has met with various approaches to overcome the problems related to solubility, application of nanotechnology is one amongst them. The present review deals with various nanocarriers and technologies that are proven to be effective in enhancing the bioavilability of poorly soluble drugs

Simplifying the mosaic description of DNA sequences

By using the Jensen-Shannon divergence, genomic DNA can be divided into compositionally distinct domains through a standard recursive segmentation procedure. Each domain, while significantly different from its neighbours, may however share compositional similarity with one or more distant (non--neighbouring) domains. We thus obtain a coarse--grained description of the given DNA string in terms of a smaller set of distinct domain labels. This yields a minimal domain description of a given DNA sequence, significantly reducing its organizational complexity. This procedure gives a new means of evaluating genomic complexity as one examines organisms ranging from bacteria to human. The mosaic organization of DNA sequences could have originated from the insertion of fragments of one genome (the parasite) inside another (the host), and we present numerical experiments that are suggestive of this scenario.Comment: 16 pages, 1 figure, Accepted for publication in Phys. Rev.