Weakly Enforced Boundary Conditions for the NURBS-Based Finite Cell Method

In this paper, we present a variationally consistent formulation for the weak enforcement of essential boundary conditions as an extension to the finite cell method, a fictitious domain method of higher order. The absence of boundary fitted elements in fictitious domain or immersed boundary methods significantly restricts a strong enforcement of essential boundary conditions to models where the boundary of the solution domain coincides with the embedding analysis domain. Penalty methods and Lagrange multiplier methods are adequate means to overcome this limitation but often suffer from various drawbacks with severe consequences for a stable and accurate solution of the governing system of equations. In this contribution, we follow the idea of NITSCHE [29] who developed a stable scheme for the solution of the Laplace problem taking weak boundary conditions into account. An extension to problems from linear elasticity shows an appropriate behavior with regard to numerical stability, accuracy and an adequate convergence behavior. NURBS are chosen as a high-order approximation basis to benefit from their smoothness and flexibility in the process of uniform model refinement

Infrared receivers for low background astronomy: Incoherent detectors and coherent devices from one micrometer to one millimeter

The status of incoherent detectors and coherent receivers over the infrared wavelength range from one micrometer to one millimeter is described. General principles of infrared receivers are included, and photon detectors, bolometers, coherent receivers, and important supporting technologies are discussed, with emphasis on their suitability for low background astronomical applications. Broad recommendations are presented and specific opportunities are identified for development of improved devices

Conditioning of hiPSC-derived cardiomyocytes using surface topography obtained with high throughput technology

Surface functionalization of polymers aims to introduce novel properties that favor bioactive responses. We have investigated the possibility of surface functionalization of polyethylene terephthalate (PET) sheets by the combination of laser ablation with hot embossing and the application of such techniques in the field of stem cell research. We investigated the response of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to topography in the low micrometer range. HiPSC-CMs are expected to offer new therapeutic tools for myocardial replacement or regeneration after an infarct or other causes of cardiac tissue loss. However, hiPSC-CMs are phenotypically immature compared to myocytes in the adult myocardium, hampering their clinical application. We aimed to develop and test a high-throughput technique for surface structuring that would improve hiPSC-CMs structural maturation. We used laser ablation with a ps-laser source in combination with nanoimprint lithography to fabricate large areas of homogeneous micron- to submicron line-like pattern with a spatial period of 3 µm on the PET surface. We evaluated cell morphology, alignment, sarcomeric myofibrils assembly, and calcium transients to evaluate phenotypic changes associated with culturing hiPSC-CMs on functionalized PET. Surface functionalization through hot embossing was able to generate, at low cost, low micrometer features on the PET surface that influenced the hiPSC-CMs phenotype, suggesting improved structural and functional maturation. This technique may be relevant for high-throughput technologies that require conditioning of hiPSC-CMs and may be useful for the production of these cells for drug screening and disease modeling applications with lower costs.Fil: Cortella, Lucas R. X.. Universidade de Sao Paulo; BrasilFil: Cestari, Idágene A.. Universidade de Sao Paulo; BrasilFil: Lahuerta, Ricardo D.. Universidade de Sao Paulo; BrasilFil: Arana, Matheus C.. Universidade de Sao Paulo; BrasilFil: Soldera, Marcos Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Rank, Andreas. Technische Universität Dresden; AlemaniaFil: Lasagni, Andrés F.. Technische Universität Dresden; AlemaniaFil: Cestari, Ismar N.. Universidade de Sao Paulo; Brasi

Stellar Populations and Mass-Loss in M15: A Spitzer Detection of Dust in the Intra-Cluster Medium

We present Spitzer Space Telescope IRAC and MIPS observations of the galactic globular cluster M15 (NGC 7078), one of the most metal-poor clusters with a [Fe/H] = -2.4. Our Spitzer images reveal a population of dusty red giants near the cluster center, a previously detected planetary nebula (PN) designated K648, and a possible detection of the intra-cluster medium (ICM) arising from mass loss episodes from the evolved stellar population. Our analysis suggests 9 (+/-2) x 10^-4 solar masses of dust is present in the core of M15, and this material has accumulated over a period of approximately 10^6 years, a timescale ten times shorter than the last galactic plane crossing event. We also present Spitzer IRS follow up observations of K648, including the detection of the [NeII] 12.81 micron line, and discuss abundances derived from infrared fine structure lines.Comment: Accepted for publication in AJ. 20 pages, 10 figures, 6 tables. Full resolution versions of figures 1, 5, 7, and 8 are available in a PDF version of this manuscript at http://ir.astro.umn.edu/~mboyer/ms_060906.pd

The Beam_Optics at the Extraction Region of SNS Ring: Revisited

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Sex determination in ratite and non ratite birds by molecular method

In spite of number of methods for sex determination in birds, it is very difficult to distinguish sex especially in ratite birds due to lack of sexual dimorphism. Chromodomain helicase DNA binding 1 gene (CHD 1) is the choice of gene for gender differentiation using PCR based molecular method. In present study, non ratite CHD gene specific primers viz. 1237L/1272H, 2550F/2718R, P2/P8, P2/P3 and ratite bird specific primers viz.W5/ W7 and W1/ K7 were used for gender differentiation in ratite birds. The ratite bird specific primer W5/W7 was the only primer, which determined the sex in emu as well as ostrich successfully, while 1237L/1272H, 2550F/2718R, P2/ P8, P2/P3 primers were unable to discriminate sex in emu and ostrich but ratite and non ratite primers can be used to discriminate the sex in non-ratite bird, primarily in chicken. In an alternative approach of PCR-RFLP, the high resolution melting curve (HRM) analysis showed conflicting pattern in both sexes of ratite birds but in chicken HRM analysis showed clear cut differential melting temperature in both sexes, hence HRM can be used for gender differentiation successfully

Strong Structural Controllability and Zero Forcing

In this chapter, we study controllability and output controllability of systems defined over graphs. Specifically, we consider a family of state-space systems, where the state matrix of each system has a zero/non-zero structure that is determined by a given directed graph. Within this setup, we investigate under which conditions all systems in this family are controllable, a property referred to as strong structural controllability. Moreover, we are interested in conditions for strong structural output controllability. We will show that the graph-theoretic concept of zero forcing is instrumental in these problems. In particular, as our first contribution, we prove necessary and sufficient conditions for strong structural controllability in terms of so-called zero forcing sets. Second, we show that zero forcing sets can also be used to state both a necessary and a sufficient condition for strong structural output controllability. In addition to these main results, we include interesting results on the controllability of subfamilies of systems and on the problem of leader selection.</p

Application of time-dependent density functional theory to optical activity

As part of a general study of the time-dependent local density approximation (TDLDA), we here report calculations of optical activity of chiral molecules. The theory automatically satisfies sum rules and the Kramers-Kronig relation between circular dichroism and optical rotatory power. We find that the theory describes the measured circular dichroism of the lowest states in methyloxirane with an accuracy of about a factor of two. In the chiral fullerene C_76 the TDLDA provides a consistent description of the optical absorption spectrum, the circular dichroism spectrum, and the optical rotatory power, except for an overall shift of the theoretical spectrum.Comment: 17 pages and 13 PostScript figure

Refractive Index of Humid Air in the Infrared: Model Fits

The theory of summation of electromagnetic line transitions is used to tabulate the Taylor expansion of the refractive index of humid air over the basic independent parameters (temperature, pressure, humidity, wavelength) in five separate infrared regions from the H to the Q band at a fixed percentage of Carbon Dioxide. These are least-squares fits to raw, highly resolved spectra for a set of temperatures from 10 to 25 C, a set of pressures from 500 to 1023 hPa, and a set of relative humidities from 5 to 60%. These choices reflect the prospective application to characterize ambient air at mountain altitudes of astronomical telescopes.Comment: Corrected exponents of c0ref, c1ref and c1p in Table

Making things happen : a model of proactive motivation

Being proactive is about making things happen, anticipating and preventing problems, and seizing opportunities. It involves self-initiated efforts to bring about change in the work environment and/or oneself to achieve a different future. The authors develop existing perspectives on this topic by identifying proactivity as a goal-driven process involving both the setting of a proactive goal (proactive goal generation) and striving to achieve that proactive goal (proactive goal striving). The authors identify a range of proactive goals that individuals can pursue in organizations. These vary on two dimensions: the future they aim to bring about (achieving a better personal fit within one’s work environment, improving the organization’s internal functioning, or enhancing the organization’s strategic fit with its environment) and whether the self or situation is being changed. The authors then identify “can do,” “reason to,” and “energized to” motivational states that prompt proactive goal generation and sustain goal striving. Can do motivation arises from perceptions of self-efficacy, control, and (low) cost. Reason to motivation relates to why someone is proactive, including reasons flowing from intrinsic, integrated, and identified motivation. Energized to motivation refers to activated positive affective states that prompt proactive goal processes. The authors suggest more distal antecedents, including individual differences (e.g., personality, values, knowledge and ability) as well as contextual variations in leadership, work design, and interpersonal climate, that influence the proactive motivational states and thereby boost or inhibit proactive goal processes. Finally, the authors summarize priorities for future researc