Dipole Cosmology: The Copernican Paradigm Beyond FLRW

We introduce the $dipole$ $cosmological$ $principle$, the idea that the Universe is a maximally Copernican cosmology, compatible with a cosmic flow. It serves as the most symmetric paradigm that generalizes the FLRW ansatz, in light of the increasingly numerous (but still tentative) hints that have emerged in the last two decades for a non-kinematic component in the CMB dipole. Einstein equations in our "dipole cosmology" are still ordinary differential equations -- but instead of the two Friedmann equations, now we have four. The two new functions can be viewed as an anisotropic scale factor that breaks the isotropy group from $SO(3)$ to $U(1)$, and a "tilt" that captures the cosmic flow velocity. The result is an axially isotropic, tilted Bianchi V/VII$_h$ cosmology. We assess the possibility of model building within the dipole cosmology paradigm, and discuss the dynamics of expansion rate, anisotropic shear and tilt, in various examples. A key observation is that the cosmic flow (tilt) can grow even while the anisotropy (shear) dies down. Remarkably, this can happen even in an era of late time acceleration.Comment: v2: References and an appendix added. 48 page

Towards A Realistic Dipole Cosmology: The Dipole Λ\LambdaCDM Model

Dipole cosmology is the maximally Copernican generalization of the FLRW paradigm that can incorporate bulk flows in the cosmic fluid. In this paper, we first discuss how multiple fluid components with independent flows can be realized in this set up. This is the necessary step to promote ``tilted" Bianchi cosmologies to a viable framework for cosmological model building involving fluid mixtures (as in FLRW). We present a dipole $\Lambda$CDM model which has radiation and matter with independent flows, with (or without) a positive cosmological constant. A remarkable feature of models containing radiation (including dipole $\Lambda$CDM) is that the $relative$ flow between radiation and matter can increase at late times, which can contribute to eg., the CMB dipole. This can happen generically in the space of initial conditions. We discuss the significance of this observation for late time cosmic tensions.Comment: 35 pages, many figures; v2 references adde

Brief isoflurane administration as an adjunct treatment to control organophosphate-induced convulsions and neuropathology

Organophosphate-based chemical agents (OP), including nerve agents and certain pesticides such as paraoxon, are potent acetylcholinesterase inhibitors that cause severe convulsions and seizures, leading to permanent central nervous system (CNS) damage if not treated promptly. The current treatment regimen for OP poisoning is intramuscular injection of atropine sulfate with an oxime such as pralidoxime (2-PAM) to mitigate cholinergic over-activation of the somatic musculature and autonomic nervous system. This treatment does not provide protection against CNS cholinergic overactivation and therefore convulsions require additional medication. Benzodiazepines are the currently accepted treatment for OP-induced convulsions, but the convulsions become refractory to these GABAA agonists and repeated dosing has diminishing effectiveness. As such, adjunct anticonvulsant treatments are needed to provide improved protection against recurrent and prolonged convulsions and the associated excitotoxic CNS damage that results from them. Previously we have shown that brief, 4-min administration of 3%–5% isoflurane in 100% oxygen has profound anticonvulsant and CNS protective effects when administered 30 min after a lethal dose of paraoxon. In this report we provide an extended time course of the effectiveness of 5% isoflurane delivered for 5 min, ranging from 60 to 180 min after a lethal dose of paraoxon in rats. We observed substantial effectiveness in preventing neuronal loss as shown by Fluoro-Jade B staining when isoflurane was administered 1 h after paraoxon, with diminishing effectiveness at 90, 120 and 180 min. In vivo magnetic resonance imaging (MRI) derived T2 and mean diffusivity (MD) values showed that 5-min isoflurane administration at a concentration of 5% prevents brain edema and tissue damage when administered 1 h after a lethal dose of paraoxon. We also observed reduced astrogliosis as shown by GFAP immunohistochemistry. Studies with continuous EEG monitoring are ongoing to demonstrate effectiveness in animal models of soman poisoning

A tilt instability in the cosmological principle

Abstract We show that the Friedmann–Lemaître–Robertson–Walker (FLRW) framework has an instability towards the growth of fluid flow anisotropies, even if the Universe is accelerating. This flow (tilt) instability in the matter sector is invisible to Cosmic No-Hair Theorem-like arguments, which typically only flag shear anisotropies in the metric. We illustrate our claims in the setting of “dipole cosmology”, the maximally Copernican generalization of FLRW that can accommodate a flow. Simple models are sufficient to show that the cosmic flow need not track the shear, even in the presence of a positive cosmological constant. We also emphasize that the growth of the tilt hair is fairly generic if the effective equation of state $$w \rightarrow -1$$ w → - 1 at late times (as it does in standard cosmology), irrespective of the precise model of dark energy. The generality of our theoretical result puts various recent observational claims about late time anisotropies and cosmic dipoles in a new light