Trend of morbidity and mortality indicators due to acute diarrheal disease in children under five years old in the State of Piauí (2000–2019)

Abstract Objectives: to analyze the trend of morbidity and mortality indicators due to acute diarrheal diseases in children under five years old in Piauí. Methods: ecological study with data from the Information Technology Department at the Public Health System. The indicators of hospitalization rate and coefficient of mortality from the disease between 2000 and 2019 were calculated. A descriptive analysis of the indicators was carried out in the studied period and by the macro-regions in the State. For trend analysis, the simple linear regression model with log-transformation was used. Trends were classified as increasing, decreasing and stable, with a significance level of 5%. Results: the average on hospitalization rate was higher in the semi-arid macro-region (36.6/1000 children under five years old) and lower in Teresina (14.9/1000 children under five years old). The mean mortality coefficients were higher in the coastal macro-region (0.98/1000 live births) and lower in Teresina (0.47/1000 live births). The indicators showed a downward trend in all analyzed locations (p<0.05). A turning point was noted from 2009, with a significant reduction in hospitalization rates in the savanna and semi-arid macro-regions. Conclusion: indicators of morbidity and mortality due to acute diarrheal diseases in children under five years old showed a downward trend in Piauí between 2000 and 2019, with differences in trends between the evaluated macro-regions

Estudo comparativo entre metodologias para o diagnóstico da leishmaniose visceral humana: uma revisão integrativa / Comparative study methodologies for the diagnosis of human visceral leishmaniasis: an integrative review

Objetivo: Discutir e comparar os testes utilizados no diagnóstico da Leishmaniose Visceral (LV). Métodos: O presente estudo trata-se de uma revisão integrativa de literatura. Para a seleção dos artigos utilizou-se a base de dados Pubmed e a amostra desta revisão constituiu-se de sete artigos. Resultados: Existem várias metodologias, destacando-se os testes rápidos, ELISA (Enzimaimunoensaio), DAT (teste de aglutinação direta), RIFI (ensaio de imunofluorescência indireta), aspiração esplênica, teste de aglutinação em látex (KAtex), PCR (Reação em cadeia da polimerase) convencional e PCR. Em maioria apresentam uma diferença se sensibilidade e especificidade a depender do fabricante, todavia os métodos de biologia molecular mostraram-se mais efetivos em relação aos demais e os testes rápidos apresentaram um grande diferencial quanto a praticidade. Considerações finais: os testes convencionalmente usados para o diagnóstico da LV apresentaram variações significativas em relação à sua sensibilidade e existe a necessidade de mais de uma metodologia diferente para a confirmação do resultado

Chagasic infection among blood donors in Brazil: an integrative review

Based on the literature, this work aimed to discuss infection by Chagas disease among blood donors in Brazil. Studies on the prevalence of Trypanosoma cruzi infection in donors or candidates for blood donation in Brazil are important. The prevalence of infection appears to be a sensitive indicator and can be a true marker of the risk of the transmission of Chagas disease by blood transfusion. Moreover, it serves as a marker of the level of transmission of the disease in a region, as well as a tool to characterize the epidemiological profile of individuals affected by the disease. The present study is an integrative review of the literature on chagasic infection among blood donors. An evaluation of the literature identified the epidemiological profile of blood donors infected by T. cruzi, which is characterized in general as men, over 30 years old, with a low level of schooling, low income and mainly coming from rural areas. Keywords: Chagas disease, Trypanosoma cruzi, Blood donor, Blood transfusion, Brazi