Data_Sheet_2_Effectiveness of using e-government platform “Absher” as a tool for noncommunicable diseases survey in Saudi Arabia 2019–2020: A cross-sectional study.PDF

BackgroundE-government platforms provide an opportunity to use a novel data source for population health surveillance (also known as e-health). Absher is a Saudi e-government platform with 23 million authenticated users, including residents and citizens in Saudi Arabia. All Absher users were invited to participate in a web-based survey to estimate the prevalence of noncommunicable diseases and their risk factors in Saudi Arabia.ObjectiveTo assess the potential of using an e-government platform (Absher) to administer web-based health surveys.MethodsA cross-sectional, web-based health survey was administered to Absher users between April 2019 and March 2020. The survey instrument included eight items and took ResultsOverall, the Absher health survey had a 24.6% response rate, with most respondents being male (84%), Saudi (67%), and between 30 and 44 years of age (49%). Overall, the prevalence of noncommunicable diseases and risk factors among respondents was high for overweight (35%) and obesity (30%) and low for asthma (6%). The prevalence of diabetes, dyslipidemia, and hypertension was between 15 and 17% on average, and 26.5% were smokers. In comparison to population-based World Health Survey estimates, the Absher survey overestimated obesity, diabetes, dyslipidemia, hypertension, and smoking rates, and underestimated overweight, whereas asthma prevalence was similar for Absher and the WHS.ConclusionsWith improvements in the study design, the use of e-government platforms can provide a useful and potentially low-cost data source for public health research.</p

Image_1_Effectiveness of using e-government platform “Absher” as a tool for noncommunicable diseases survey in Saudi Arabia 2019–2020: A cross-sectional study.PNG

BackgroundE-government platforms provide an opportunity to use a novel data source for population health surveillance (also known as e-health). Absher is a Saudi e-government platform with 23 million authenticated users, including residents and citizens in Saudi Arabia. All Absher users were invited to participate in a web-based survey to estimate the prevalence of noncommunicable diseases and their risk factors in Saudi Arabia.ObjectiveTo assess the potential of using an e-government platform (Absher) to administer web-based health surveys.MethodsA cross-sectional, web-based health survey was administered to Absher users between April 2019 and March 2020. The survey instrument included eight items and took ResultsOverall, the Absher health survey had a 24.6% response rate, with most respondents being male (84%), Saudi (67%), and between 30 and 44 years of age (49%). Overall, the prevalence of noncommunicable diseases and risk factors among respondents was high for overweight (35%) and obesity (30%) and low for asthma (6%). The prevalence of diabetes, dyslipidemia, and hypertension was between 15 and 17% on average, and 26.5% were smokers. In comparison to population-based World Health Survey estimates, the Absher survey overestimated obesity, diabetes, dyslipidemia, hypertension, and smoking rates, and underestimated overweight, whereas asthma prevalence was similar for Absher and the WHS.ConclusionsWith improvements in the study design, the use of e-government platforms can provide a useful and potentially low-cost data source for public health research.</p

MOESM3 of ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Additional file 3. Alteration of levels of circulating cytokines/chemokines in C57BL/6 and ApoE−/− mice with induction of arthritis. Serum levels from non-arthritic and arthritic C57BL/6 (control, n = 2 non-arthritic and n = 13 arthritic) and ApoE−/− (n = 3 non-arthritic and n = 6 arthritic) mice at 4–6 months. Data are represented as mean ± SEM. * denotes statistically significant differences. *p < 0.05, **p < 0.01,***p < 0.001

Additional file 2: Table S2. of Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

ANOVA comparison data from Affymetrix QuantiGene 2.0 custom panel 21522 for analysis of macrophage polarization. (XLS 68 kb

Additional file 1: Table S1. of Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

Affymetrix QuantiGene 2.0 custom panel 21522 for analysis of macrophage polarization. Figure S1. Genotype validation of splenocyte populations. Figure S2. Genotype validation of BMDMs. Figure S3. TLR9 in vivo activation induces upregulation of serum cytokines and chemokines at similar levels in Casp8 fl/fl and Cre LysM Casp8 fl/fl mice. Figure S4. Caspase-8–deficient splenic myeloid populations are not predisposed to aberrant death. Figure S5. Caspase-8–deficient BMDMs express Fas. Figure S6. Caspase-8–deficient BMDMs undergo caspase-independent cell death in response to apoptotic stimuli. Figure S7. Caspase-8 deficiency in macrophages alters the response to TLR activation in vitro. Figure S8. Caspase-8 deficiency in macrophages alters the genetic profile in response to macrophage polarization in vitro. (PDF 5409 kb