4 research outputs found
Electrophilic Reaction of 2,2,2-TrifluoroÂdiazoethane with the in Situ Generated <i>N</i>‑Heterocyclic Carbenes: Access to <i>N</i>‑Aminoguanidines
A facile and efficient
electrophilic reaction of 2,2,2-trifluorodiazoethane
(CF<sub>3</sub>CHN<sub>2</sub>) with the in situ generated <i>N</i>-heterocyclic carbenes is reported. Under basic conditions,
a series of trifluoromethylated <i>N</i>-aminoguanidines
were obtained in good to high yields. Furthermore, this protocol was
applied in the synthesis of the agrochemical Imidacloprid analogue
Electrophilic Reaction of 2,2,2-TrifluoroÂdiazoethane with the in Situ Generated <i>N</i>‑Heterocyclic Carbenes: Access to <i>N</i>‑Aminoguanidines
A facile and efficient
electrophilic reaction of 2,2,2-trifluorodiazoethane
(CF<sub>3</sub>CHN<sub>2</sub>) with the in situ generated <i>N</i>-heterocyclic carbenes is reported. Under basic conditions,
a series of trifluoromethylated <i>N</i>-aminoguanidines
were obtained in good to high yields. Furthermore, this protocol was
applied in the synthesis of the agrochemical Imidacloprid analogue
Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β‑Keto Acids with 3‑Hydroxy-3-indolyloxindoles
A chiral phosphoric acid catalyzed
enantioselective decarboxylative
alkylation of β-keto acids with 3-hydroxy-3-indolyloxindoles
is described in this context. This method tolerates a series of aromatic
and aliphatic β-keto acids as well as substituted 3-hydroxy-3-indolyloxindoles,
affording the corresponding chiral 3-functionalized 3-indolyloxindoles
in high yields (up to 98%) and enantioselectivities (up to 99% ee)
K<sub>2</sub>CO<sub>3</sub>‑Catalyzed (3 + 2) Cycloaddition Reaction of <i>N</i>‑2,2,2-Trifluoroethylisatin Ketimines with Azodicarboxylates: Access to Spirooxindoles Containing Trifluoromethyl-1,2,4-triazolines
Potassium
carbonate-catalyzed (3 + 2) cycloaddition reaction between N-2,2,2-trifluoroethylisatin ketimines and azodicarboxylates
has been developed, constructing a series of novel N-heterocycle infused spirooxindoles in good to excellent yields (up
to 98%) under milder conditions. The presence of both biologically
active oxindole and trifluoromethyl-1,2,4-triazoline moieties in these
novel spirocyclic compounds would provide new lead structures in the
discovery of heterocyclic compounds with potential pharmaceutical
activities