Spatial Geometry and the Wu-Yang Ambiguity

We display continuous families of SU(2) vector potentials $A_i^a(x)$ in 3 space dimensions which generate the same magnetic field $B^{ai}(x)$ (with det $B\neq 0$). These Wu-Yang families are obtained from the Einstein equation $R_{ij}=-2G_{ij}$ derived recently via a local map of the gauge field system into a spatial geometry with $2$-tensor $G_{ij}=B^a{}_i B^a{}_j\det B$ and connection $\Gamma_{jk}^i$ with torsion defined from gauge covariant derivatives of $B$.Comment: Based on talks given by R. Khuri at PASCOS-94, Syracuse University, May 1994 and at Gursey Memorial Conference I, Istanbul, June 1994, 7 pages, TeX (typo in first Author's name is corrected.

TiO₂ Nanoparticles Prepared by Sol-Gel Method for Anode Application in Lithium-Ion Batteries

TiO 2 nanoparticles are prepared via sol-gel method using titanium tetraisopropoxide (TTIP) as a precursor under refluxing and controlled pH. It is found that pure anatase phase is obtained with pH 10. Further characterization studies are carried out on pure nanoparticle anatase phase by XRD, SEM, and transmission electron microscope (TEM). Their electrochemical performances as anode material in lithium-ion batteries are investigated by cyclic voltammetry, galvanostatic cycling, and rate capability measurements. A high discharge capacity of 321 mAh/g (vs. 335 mAh/g theoretical) is achieved at 1C rate. After the first galvanostatic charge/discharge cycle, voltage profiles show plateaus at 1.75 and 1.95 V versus Li at discharge and charge, respectively. High Coulombic efficiency (>99%) is maintained after 300 cycles, which makes anatase TiO 2 nanoparticles prepared by sol-gel method, a very promising material for anode application in lithium rechargeable batteries

Halal logistics legal framework: Malaysia perspective

Halal logistics is one of the profitable industries in Malaysia with demand from local and international clients. Though there are regulations and standards protecting this industry, the enforcement on these two demands attention and further study as there are still reports of abuse of the Halal logo due to failure to segregation of halal and non-halal products during the logistics chains. Currently, there are very limited literature review on enforcement of halal logistics. Hence, this research seeks to discover the critical factors for effective enforcement of halal logistics in Malaysia. Applying a qualitative method, semi-structured interviews were conducted with stakeholders of the industry. Besides that, references were made to previous publication, case laws and legal documents. The interviews were recorded, transcribed, coded and reconciled. By using Nvivo software (12 Plus), the researcher coded the transcriptions and identify the themes and sub-themes. The findings discovered the following elements as critical within the industry: First the source of laws applicable in halal logistics, the duties and responsibilities of legal agencies and the due process (legal proceedings). This research will focus on the critical elements which are the sources of laws and the due process. The result shows that with regards to the sources of law, all participants agreed criminal laws are applicable in Halal logistics cases. However, only the academician and Halal logistics operator agreed civil laws should be included. Moreover, they also concurred that inclusive application of civils laws should also extend legal exposure to the halal logistics operators in order to manage the activities and avoid mistakes and cross-contamination

Exploring Strategies to Enhance TVET Engagement in Maldives to Improve Youth Career Development

Several aspects of the Maldives’ recent development pattern highlight imbalances between labor demand and supply. Public sector jobs are predominantly in the civil service with the rapid expansion of cadres in the 1990s and 2000s. However, with the increasing standard of living over time, the labor market has become more challenging for Maldivians in general. Increasing educational attainment among the younger generation and expectations have coincided/collided with the rapid growth in low-skill service jobs associated with tourism and construction, leading to a mismatch in skills supply and demand. Despite the high levels of growth and labor market conditions in public investments, tourism, fisheries and non-tradable tourism related activities, important challenges remain for young Maldivians. TVET is perceived as second-class option to most of the youth. Many reasons that cloaked these issues such as lack of awareness, publicity and career readiness. This research seeks to identify the issue and challenges and strategies that can be implemented to enhance career development among Maldivian youth on TVET. Mixed method has been adapted in this research by employing questionnaires and conducting interviews. 200 respondents participated in the survey and five experts were involved in the interviews. Data were analysed quantitatively for survey and thematic analysis for the qualitative data. According to the findings, a majority of respondents (81.7%) have heard of Technical and Vocational Education and Training (TVET), but less than half (45.2%) understand that it can lead to better employment opportunities. Experts have identified seven strategies to improve TVET for youth career development, including promoting it through electronic media, launching a national campaign, strengthening partnerships with industry, branding and holding skills competitions. This information is valuable for policymakers and stakeholders in the Maldives as they work to design and implement effective and coordinated government support for TVET

Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways

BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States, suggesting that novel strategies for the prevention and treatment of PDAC are urgently needed. K-ras mutations are observed in >90% of pancreatic cancer, suggesting its role in the initiation and early developmental stages of PDAC. In order to gain mechanistic insight as to the role of mutated K-ras, several mouse models have been developed by targeting a conditionally mutated K-ras(G12D) for recapitulating PDAC. A significant co-operativity has been shown in tumor development and metastasis in a compound mouse model with activated K-ras and Ink4a/Arf deficiency. However, the molecular mechanism(s) by which K-ras and Ink4a/Arf deficiency contribute to PDAC has not been fully elucidated. METHODOLOGY/PRINCIPAL FINDINGS:To assess the molecular mechanism(s) that are involved in the development of PDAC in the compound transgenic mice with activated K-ras and Ink4a/Arf deficiency, we used multiple methods, such as Real-time RT-PCR, western blotting assay, immunohistochemistry, MTT assay, invasion, EMSA and ELISA. We found that the deletion of Ink4a/Arf in K-ras(G12D) expressing mice leads to PDAC, which is in part mediated through the activation of Notch and NF-κB signaling pathways. Moreover, we found down-regulation of miR-200 family, which could also play important roles in tumor development and progression of PDAC in the compound transgenic mice. CONCLUSIONS/SIGNIFICANCE:Our results suggest that the activation of Notch and NF-κB together with the loss of miR-200 family is mechanistically linked with the development and progression of PDAC in the compound K-ras(G12D) and Ink4a/Arf deficient transgenic mice

Antimicrobial, Antioxidant and Cytotoxic Activities and Phytochemical Screening of Some Yemeni Medicinal Plants

The traditional medicine still plays an important role in the primary health care in Yemen. The current study represents the investigation of 16 selected plants, which were collected from different localities of Yemen. The plants were dried and extracted with two different solvents (methanol and hot water) to yield 34 crude extracts. The obtained extracts were tested for their antimicrobial activity against three Gram-positive bacteria, two Gram-negative bacteria, one yeast species and three multiresistant Staphylococcus strains using agar diffusion method, for their antioxidant activity using scavenging activity of DPPH radical method and for their cytotoxic activity using the neutral red uptake assay. In addition, a phytochemical screening of the methanolic extracts was done. Antibacterial activity was shown only against Gram-positive bacteria, among them multiresistant bacteria. The highest antimicrobial activity was exhibited by the methanolic extracts of Acalypha fruticosa, Centaurea pseudosinaica, Dodonaea viscosa, Jatropha variegata, Lippia citriodora, Plectranthus hadiensis, Tragia pungens and Verbascum bottae. Six methanolic extracts especially those of A. fruticosa, Actiniopteris semiflabellata, D. viscosa, P. hadiensis, T. pungens and V. bottae showed high free radical scavenging activity. Moreover, remarkable cytotoxic activity against FL-cells was found for the methanolic extracts of A. fruticosa, Iris albicans, L. citriodora and T. pungens. The phytochemical screening demonstrated the presence of different types of compounds like flavonoids, terpenoids and others, which could be responsible for the obtained activities

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation

BACKGROUND: Numerous interactions between the coagulation and complement systems have been shown. Recently, links between coagulation and mannan-binding lectin-associated serine protease-1 (MASP-1) of the complement lectin pathway have been proposed. Our aim was to investigate MASP-1 activation of factor XIII (FXIII), fibrinogen, prothrombin, and thrombin-activatable fibrinolysis inhibitor (TAFI) in plasma-based systems, and to analyse effects of MASP-1 on plasma clot formation, structure and lysis. METHODOLOGY/PRINCIPAL FINDINGS: We used a FXIII incorporation assay and specific assays to measure the activation products prothrombin fragment F1+2, fibrinopeptide A (FPA), and activated TAFI (TAFIa). Clot formation and lysis were assessed by turbidimetric assay. Clot structure was studied by scanning electron microscopy. MASP-1 activated FXIII and, contrary to thrombin, induced FXIII activity faster in the Val34 than the Leu34 variant. MASP-1-dependent generation of F1+2, FPA and TAFIa showed a dose-dependent response in normal citrated plasma (NCP), albeit MASP-1 was much less efficient than FXa or thrombin. MASP-1 activation of prothrombin and TAFI cleavage were confirmed in purified systems. No FPA generation was observed in prothrombin-depleted plasma. MASP-1 induced clot formation in NCP, affected clot structure, and prolonged clot lysis. CONCLUSIONS/SIGNIFICANCE: We show that MASP-1 interacts with plasma clot formation on different levels and influences fibrin structure. Although MASP-1-induced fibrin formation is thrombin-dependent, MASP-1 directly activates prothrombin, FXIII and TAFI. We suggest that MASP-1, in concerted action with other complement and coagulation proteins, may play a role in fibrin clot formation

The North American tree-ring fire-scar network

Fire regimes in North American forests are diverse and modern fire records are often too short to capture important patterns, trends, feedbacks, and drivers of variability. Tree-ring fire scars provide valuable perspectives on fire regimes, including centuries-long records of fire year, season, frequency, severity, and size. Here, we introduce the newly compiled North American tree-ring fire-scar network (NAFSN), which contains 2562 sites, >37,000 fire-scarred trees, and covers large parts of North America. We investigate the NAFSN in terms of geography, sample depth, vegetation, topography, climate, and human land use. Fire scars are found in most ecoregions, from boreal forests in northern Alaska and Canada to subtropical forests in southern Florida and Mexico. The network includes 91 tree species, but is dominated by gymnosperms in the genus Pinus. Fire scars are found from sea level to >4000-m elevation and across a range of topographic settings that vary by ecoregion. Multiple regions are densely sampled (e.g., >1000 fire-scarred trees), enabling new spatial analyses such as reconstructions of area burned. To demonstrate the potential of the network, we compared the climate space of the NAFSN to those of modern fires and forests; the NAFSN spans a climate space largely representative of the forested areas in North America, with notable gaps in warmer tropical climates. Modern fires are burning in similar climate spaces as historical fires, but disproportionately in warmer regions compared to the historical record, possibly related to under-sampling of warm subtropical forests or supporting observations of changing fire regimes. The historical influence of Indigenous and non-Indigenous human land use on fire regimes varies in space and time. A 20th century fire deficit associated with human activities is evident in many regions, yet fire regimes characterized by frequent surface fires are still active in some areas (e.g., Mexico and the southeastern United States). These analyses provide a foundation and framework for future studies using the hundreds of thousands of annually- to sub-annually-resolved tree-ring records of fire spanning centuries, which will further advance our understanding of the interactions among fire, climate, topography, vegetation, and humans across North America