Cultural affordances : scaffolding local worlds through shared intentionality and regimes of attention

Abstract: In this paper we outline a framework for the study of the mechanisms involved in the engagement of human agents with cultural affordances. Our aim is to better understand how culture and context interact with human biology to shape human behavior, cognition, and experience. We attempt to integrate several related approaches in the study of the embodied, cognitive, and affective substrates of sociality and culture and the sociocultural scaffolding of experience. The integrative framework we propose bridges cognitive and social sciences to provide (i) an expanded concept of ‘affordance’ that extends to sociocultural forms of life, and (ii) a multilevel account of the socioculturally scaffolded forms of affordance learning and the transmission of affordances in patterned sociocultural practices and regimes of shared attention. This framework provides an account of how cultural content and normative practices are built on a foundation of contentless basic mental processes that acquire content through immersive participation of the agent in social practices that regulate joint attention and shared intentionalit

Extended active inference: constructing predictive cognition beyond skulls

Cognitive niche construction is construed as a form of instrumental intelligence, whereby organisms create and maintain cause–effect models of their niche as guides for fitness influencing behavior. Extended mind theory claims that cognitive processes extend beyond the brain to include predictable states of the world – that function as cognitive extensions to support the performance of certain cognitive tasks. Predictive processing in cognitive science assumes that organisms (and their brains) embody predictive models of the world that are leveraged to guide adaptive behavior. On that view, standard cognitive functions – such as action, perception and learning – are geared towards the optimization of the organism’s predictive (i.e., generative) models of the world. Recent developments in predictive processing – known as active inference – suggest that niche construction is an emergent strategy for optimizing generative models. In this paper, based on the active inference formulation of niche construction, we first argue that cognitive niche construction can be studied as a cognitive function. Second, we argue that under the lens of active inference, cognitive niche construction can be viewed as a process of constructing, optimizing, and leveraging cognitive extensions; what we call extended active inference

First principles in the life sciences: the free-energy principle, organicism, and mechanism

The free-energy principle states that all systems that minimize their free energy resist a tendency to physical disintegration. Originally proposed to account for perception, learning, and action, the free-energy principle has been applied to the evolution, development, morphology, anatomy and function of the brain, and has been called a postulate, an unfalsifiable principle, a natural law, and an imperative. While it might afford a theoretical foundation for understanding the relationship between environment, life, and mind, its epistemic status is unclear. Also unclear is how the free-energy principle relates to prominent theoretical approaches to life science phenomena, such as organicism and mechanism. This paper clarifies both issues, and identifies limits and prospects for the free-energy principle as a first principle in the life sciences

Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

Introduction: Giant cell arteritis (GCA) is an autoimmune disease commonest in Northern Europe and Scandinavia. Previous studies report various associations with HLA-DRB1*04 and HLA-DRB1*01; HLA-DRB1 alleles show a gradient in population prevalence within Europe. Our aims were (1) to determine which amino acid residues within HLA-DRB1 best explained HLA-DRB1 allele susceptibility and protective effects in GCA, seen in UK data combined in meta-analysis with previously published data, and (2) to determine whether the incidence of GCA in different countries is associated with the population prevalence of the HLA-DRB1 alleles that we identified in our meta-analysis. Methods: GCA patients from the UK GCA Consortium were genotyped by using single-strand oligonucleotide polymerization, allele-specific polymerase chain reaction, and direct sequencing. Meta-analysis was used to compare and combine our results with published data, and public databases were used to identify amino acid residues that may explain observed susceptibility/protective effects. Finally, we determined the relationship of HLA-DRB1*04 population carrier frequency and latitude to GCA incidence reported in different countries. Results: In our UK data (225 cases and 1378 controls), HLA-DRB1*04 carriage was associated with GCA susceptibility (odds ratio (OR) = 2.69, P = 1.5×10 −11 ), but HLA-DRB1*01 was protective (adjusted OR = 0.55, P = 0.0046). In meta-analysis combined with 14 published studies (an additional 691 cases and 4038 controls), protective effects were seen from HLA-DR2, which comprises HLA-DRB1*15 and HLA-DRB1*16 (OR = 0.65, P = 8.2×10 −6 ) and possibly from HLA-DRB1*01 (OR = 0.73, P = 0.037). GCA incidence (n = 17 countries) was associated with population HLA-DRB1*04 allele frequency (P = 0.008; adjusted R 2 = 0.51 on univariable analysis, adjusted R 2 = 0.62 after also including latitude); latitude also made an independent contribution. Conclusions: We confirm that HLA-DRB1*04 is a GCA susceptibility allele. The susceptibility data are best explained by amino acid risk residues V, H, and H at positions 11, 13, and 33, contrary to previous suggestions of amino acids in the second hypervariable region. Worldwide, GCA incidence was independently associated both with population frequency of HLA-DRB1*04 and with latitude itself. We conclude that variation in population HLA-DRB1*04 frequency may partly explain variations in GCA incidence and that HLA-DRB1*04 may warrant investigation as a potential prognostic or predictive biomarker

The role of valence and meta-awareness in mirror self-recognition using hierarchical active inference

The underlying processes that enable self-perception are crucial for understanding multisensory integration, body perception and action, and the development of the self. Previous computational models have overlooked an essential aspect: affective or emotional components cannot be uncoupled from the self-recognition process. Hence, here we propose a computational approach to study self-recognition that incorporates affect using state-of-the-art hierarchical active inference. We evaluated our model in a synthetic experiment inspired by the mirror self-recognition test, a benchmark for evaluating self-recognition in animals and humans alike. Results show that i) negative valence arises when the agent recognizes itself and learns something unexpected about its internal states. Furthermore, ii) the agent in the presence of strong prior expectations of a negative affective state will avoid the mirror altogether in anticipation of an undesired learning process. Both results are in line with current literature on human self-recognition