484 research outputs found
Overview of ASDEX Upgrade results
The ASDEX Upgrade (AUG) programme is directed towards physics input to critical
elements of the ITER design and the preparation of ITER operation, as well as addressing
physics issues for a future DEMO design. Since 2015, AUG is equipped with a new pair of
3-strap ICRF antennas, which were designed for a reduction of tungsten release during ICRF
operation. As predicted, a factor two reduction on the ICRF-induced W plasma content could
be achieved by the reduction of the sheath voltage at the antenna limiters via the compensation
of the image currents of the central and side straps in the antenna frame. There are two main
operational scenario lines in AUG. Experiments with low collisionality, which comprise
current drive, ELM mitigation/suppression and fast ion physics, are mainly done with freshly
boronized walls to reduce the tungsten influx at these high edge temperature conditions. Full
ELM suppression and non-inductive operation up to a plasma current of Ip = 0.8 MA could
be obtained at low plasma density. Plasma exhaust is studied under conditions of high neutral
divertor pressure and separatrix electron density, where a fresh boronization is not required.
Substantial progress could be achieved for the understanding of the confinement degradation
by strong D puffing and the improvement with nitrogen or carbon seeding. Inward/outward
shifts of the electron density profile relative to the temperature profile effect the edge stability
via the pressure profile changes and lead to improved/decreased pedestal performance.
Seeding and D gas puffing are found to effect the core fueling via changes in a region of high
density on the high field side (HFSHD).
The integration of all above mentioned operational scenarios will be feasible and
naturally obtained in a large device where the edge is more opaque for neutrals and higher
plasma temperatures provide a lower collisionality. The combination of exhaust control
with pellet fueling has been successfully demonstrated. High divertor enrichment values of
nitrogen EN 10 have been obtained during pellet injection, which is a prerequisite for the
simultaneous achievement of good core plasma purity and high divertor radiation levels.
Impurity accumulation observed in the all-metal AUG device caused by the strong neoclassical
inward transport of tungsten in the pedestal is expected to be relieved by the higher
neoclassical temperature screening in larger devices.European Commission (EUROfusion 633053
ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol
Attention deficit hyperactivity disorder; Digital phenotyping; Remote monitoringTrastorno por déficit de atención con hiperactividad; Fenotipado digital; Monitoreo remotoTranstorn per dèficit d'atenció amb hiperactivitat; Fenotipat digital; Monitorització remotaBackground
Emerging evidence points at substantial comorbidity between adult attention deficit hyperactivity disorder (ADHD) and cardiometabolic diseases, but our understanding of the comorbidity and how to manage cardiometabolic disease in adults with ADHD is limited. The ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA) project uses remote measurement technology to obtain real-world data from daily life to assess the extent to which ADHD medication treatment and physical activity, individually and jointly, may influence cardiometabolic risks in adults with ADHD. Our second main aim is to obtain valuable real-world data on adherence to pharmacological treatment and its predictors and correlates during daily life from adults with ADHD.
Methods
ART-CARMA is a multi-site prospective cohort study within the EU-funded collaboration ‘TIMESPAN’ (Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients) that will recruit 300 adults from adult ADHD waiting lists. The participants will be monitored remotely over a period of 12 months that starts from pre-treatment initiation. Passive monitoring, which involves the participants wearing a wrist-worn device (EmbracePlus) and downloading the RADAR-base Passive App and the Empatica Care App on their smartphone, provides ongoing data collection on a wide range of variables, such as physical activity, sleep, pulse rate (PR) and pulse rate variability (PRV), systolic peaks, electrodermal activity (EDA), oxygen saturation (SpO2), peripheral temperature, smartphone usage including social connectivity, and the environment (e.g. ambient noise, light levels, relative location). By combining data across these variables measured, processes such as physical activity, sleep, autonomic arousal, and indicators of cardiovascular health can be captured. Active remote monitoring involves the participant completing tasks using a smartphone app (such as completing clinical questionnaires or speech tasks), measuring their blood pressure and weight, or using a PC/laptop (cognitive tasks). The ART system is built on the RADAR-base mobile-health platform.
Discussion
The long-term goal is to use these data to improve the management of cardiometabolic disease in adults with ADHD, and to improve ADHD medication treatment adherence and the personalisation of treatment.The ART-CARMA study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 965381. This communication reflects the views of the authors, and the European Commission is not responsible for any use that may be made of the information it contains. HD is supported by the UK Medical Research Council (MR/N013700/1) and King’s College London member of the MRC Doctoral Training Partnership in Biomedical Sciences
Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads
to tolerable heat and particle loads on the wall is a major challenge. The new European
medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade
(AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide
parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal
and SOL parameters are not achievable simultaneously in present day devices. A two prong
approach is adopted. On the one hand, scenarios with tolerable transient heat and particle
loads, including active edge localised mode (ELM) control are developed. On the other hand,
divertor solutions including advanced magnetic configurations are studied. Considerable
progress has been made on both approaches, in particular in the fields of: ELM control with
resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control,
as well as filamentary scrape-off-layer transport. For example full ELM suppression has now
been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement
HH(98,y2) 0.95. Advances have been made with respect to detachment onset and control.
Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor)
shed new light on SOL physics. Cross field filamentary transport has been characterised in a
wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental
understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the
SOL also play a crucial role for ELM stability and access to small ELM regimes.European Commission (EUROfusion 633053
Medium-modified evolution of multiparticle production in jets in heavy-ion collisions
The energy evolution of medium-modified average multiplicities and
multiplicity fluctuations in quark and gluon jets produced in heavy-ion
collisions is investigated from a toy QCD-inspired model. In this model, we use
modified splitting functions accounting for medium-enhanced radiation of gluons
by a fast parton which propagates through the quark gluon plasma. The leading
contribution of the standard production of soft hadrons is found to be enhanced
by the factor while next-to-leading order (NLO) corrections are
suppressed by , where the nuclear parameter accounts for
the induced-soft gluons in the hot medium. The role of next-to-next-to-leading
order corrections (NNLO) is studied and the large amount of medium-induced soft
gluons is found to drastically affect the convergence of the perturbative
series. Our results for such global observables are cross-checked and compared
with their limits in the vacuum and a new method for solving the second
multiplicity correlator evolution equations is proposed.Comment: 21 pages and 8 figures, typo corrections, references adde
Validation of the Spanish version of the Borderline Personality Disorder Checklist (BPD Checklist) in a sample of BPD patients: Study of psychometric properties
The Conners Continuous Performance Test CPT3™: Is it a reliable marker to predict neurocognitive dysfunction in Myalgic encephalomyelitis/chronic fatigue syndrome?
IntroductionThe main objective is to delimit the cognitive dysfunction associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in adult patients by applying the Continuous Performance Test (CPT3™). Additionally, provide empirical evidence on the usefulness of this computerized neuropsychological test to assess ME/CFS.MethodThe final sample (n = 225; 158 Patients/67 Healthy controls) were recruited in a Central Sensitization Syndromes (CSS) specialized unit in a tertiary hospital. All participants were administered this neuropsychological test.ResultsThere were significant differences between ME/CFS and healthy controls in all the main measures of CPT3™. Mainly, patients had a worse indicator of inattentiveness, sustained attention, vigilance, impulsivity, slow reaction time, and more atypical T-scores, which is associated with a likelihood of having a disorder characterized by attention deficits, such as Attention Deficit Hyperactivity Disorder (ADHD). In addition, relevant correlations were obtained between the CPT3™ variables in the patient’s group. The most discriminative indicators of ME/CFS patients were Variability and Hit Reaction Time, both measures of response speed.ConclusionThe CPT3™ is a helpful tool to discriminate neurocognitive impairments from attention and response speed in ME/CFS patients, and it could be used as a marker of ME/CFS severity for diagnosing or monitoring this disease
The role of environmental influences in the complex relationship between borderline personality disorder and attention-deficit/hyperactivity disorder : review of recent findings
In recent years, the existence of possible developmental pathways from childhood Attention-Deficit/Hyperactivity Disorder (ADHD) to adult Borderline Personality Disorder (BPD) has been suggested. The existence of common genetic factors has been described but there is little evidence on the role of environmental factors in the possible transition from one disorder to another throughout life. The main goal of this work is to review the literature about the existing evidence on childhood traumas as factors that mediate the risk of developing BPD in children with ADHD. A literature search was conducted using PubMed, Science Direct and PsychInfo databases. Criteria included studies of BPD and ADHD relationships and childhood traumas as environmental influences from epidemiological or clinical samples. The review only identified 4 studies that matched the search criteria. All studies retrospectively analyzed childhood traumas, and adult patients with BPD, with or without comorbid ADHD, were the most frequently mentioned. The analyzed evidence reinforces the relationship between the number of childhood traumas and higher clinical severity. Three of these analyzed studies describe an increased the risk of children with ADHD who report emotional and sexual traumatic experiences to develop BPD in adulthood. The experience of traumatic childhood events, especially those of an emotional type, may have a mediating effect of an increased risk of developing adult BPD in childhood ADHD patients. However, to consider them as risk factors, more studies, and especially longitudinal studies, are necessary to clarify the probable transactional process between the two disorders. Evidence from these studies may be helpful to develop early intervention programs to reduce the functional impairment associated with the two disorders
Functional improvement and correlations with symptomatic improvement in adults with attention deficit hyperactivity disorder receiving long-acting methylphenidate
Item does not contain fulltextBACKGROUND: Data on the relationship between core symptoms and daily functioning in adults with attention deficit hyperactivity disorder (ADHD) are limited. Daily functioning was assessed as part of an open-label extension, and associations with symptom scores were evaluated. METHOD: After a 5-week double-blind study with adults with ADHD receiving osmotic-controlled release oral delivery system (OROS) methylphenidate (MPH) 18, 36 or 72 mg/day, or placebo, participants were eligible for a 7-week open-label extension in which all patients received OROS MPH. Data for the Conners' Adult ADHD Rating Scale - Observer: Screening Version (CAARS-O:SV) (primary endpoint) have been presented previously. Secondary endpoints included the observer self-reported short version of the CAARS (CAARS-S:S) and the Clinical Global Impressions - Severity Scale (CGI-S). Daily functioning and quality of life were assessed using the Sheehan Disability Scale (SDS) and the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) respectively. In post-hoc analyses, changes in CAARS-O:SV were evaluated in subgroups. Relationships between symptom and functional outcomes were evaluated in a multivariate regression analysis. RESULTS: A total of 370 patients entered the open-label extension. Significant improvements from baseline in CAARS-O:SV were similar regardless of sex, ADHD subtype, prior treatment or psychiatric co-morbidity. Significant improvements from double-blind baseline were also seen for the CAARS-S:S, CGI-S, SDS and Q-LES-Q. Improvements in the CAARS-O:SV Hyperactivity/Impulsivity subscale were associated with improvements in SDS total and subscale scores, and in the Q-LES-Q score at open-label endpoint. Improvements in CAARS-O:SV Inattention subscale and CGI-S scores were not significantly associated with functional changes. CONCLUSIONS: Improvements in ADHD symptoms relating to hyperactivity and impulsivity in adults receiving OROS MPH are associated with improvements in daily functioning and quality of life.1 januari 201
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