The eye of the team : critical incidents analysis of team metaphors used by teams in a health setting : a thesis submitted in partial fulfillment of the requirements for the degree of Master of Arts in Psychology at Massey University

This study sought to explore working teams' mental models of their success and failure, to cast light on what improves rather than undermines the teams' performance. Implicit team mental models may become explicit through exploring the language, specifically metaphors, that teams use to describe successful and unsuccessful performance. Ten teams comprising 69 individuals from a large district health board and including one all Māori team, participated in semi-structured interviews, that focused on the positive and negative critical incidents, when working together. Twin Content analyses of each type of incident revealed classical attribution biases, for example self-serving biases (team failures externalised using system metaphors as in "It is not our fault, it is the computer's fault" and successes internalised as in "the high standard of work is a reflection on the integrity and skills of the team"). At the same time however teams occasionally sidestepped these biases by reflecting on whether they could have achieved even more. Unlike their counterparts, the single all-Māori team used the same "two worlds" metaphor to describe both success and failure through bi-cultural harmony and bi-cultural conflict. Discussion focuses on how metaphors enhance team development. For example through discourse analysis of training sessions, teams may become aware of what biases the team is engaging in, thereby fuelling organisational learning

Simulating the Martian Chemical Enivronment

We report on new analogue materials to simulate Martian rocks and soils, especially under realistic redox conditions

The Physio-Chemical Properties for the Interior of Enceladus

We have reviewed the current physical and chemical conditions of the Enceladus sub-surface environment, including the composition, temperature, pH and pressure. Here we have defined some of these parameters and, through the aid of modelling, will define and refine the remaining parameters needed for our experimental work. Simulations of the chemical reactions occurring within Enceladus can then be carried out to advance our understanding of the internal environment of Enceladus and help evaluate its potential habitability. Once a better understanding of the chemical reactions occurring at the rock-water interface has been carried out, then potential analogues on Earth can be evaluated and known microbial life can be tested to see if it could survive the conditions of Enceladus

Experimental and simulation efforts in the astrobiological exploration of exooceans

The icy satellites of Jupiter and Saturn are perhaps the most promising places in the Solar System regarding habitability. However, the potential habitable environments are hidden underneath km-thick ice shells. The discovery of Enceladus’ plume by the Cassini mission has provided vital clues in our understanding of the processes occurring within the interior of exooceans. To interpret these data and to help configure instruments for future missions, controlled laboratory experiments and simulations are needed. This review aims to bring together studies and experimental designs from various scientific fields currently investigating the icy moons, including planetary sciences, chemistry, (micro-)biology, geology, glaciology, etc. This chapter provides an overview of successful in situ, in silico, and in vitro experiments, which explore different regions of interest on icy moons, i.e. a potential plume, surface, icy shell, water and brines, hydrothermal vents, and the rocky core

Cultural differences impacting on therapists’ interpretation and understanding of clients’ appraisals in post-traumatic stress disorder

The primary aim of this study is to explore the impact of cultural differences on therapists' interpretation and understanding of clients' appraisals in post-traumatic stress disorder (PTSD). A review of the literature provides only limited information on how therapists interpret and understand clients' appraisals in PTSD. Most of the studies reviewed indicate that cultural differences impact clients' appraisals in PTSD. Thematic analysis has been selected as the research methodology for this study. A qualitative approach is employed, with data collected through semi-structured interviews from the lived experiences of therapists from various modalities. Eight participants were selected from different organisations, including the independent sector, Improving Access to Psychological Therapies (IAPT) within the National Health Service (NHS), and a third sector charity/voluntary organisation. A thematic approach was used to analyse the data obtained from the therapists' lived experiences. The emerging themes are critically analysed and discussed in the context of exploring how cultural differences impact therapists' interpretation and understanding of clients' appraisals in PTSD. The findings indicate that cultural differences affect therapists' interpretation and understanding of clients' appraisals, as evidenced by the emerging themes of cultural differences in clients' appraisals of their trauma. As this study is only an exploration of how cultural differences impact therapists' interpretation and understanding of clients' appraisals in PTSD, further research is required in this area of psychotherapy

Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx43 was increased in the TMZ-resistant low passage and cell lines. This correlated with the data in The Cancer Genome Atlas. Cx43 knockdown, reporter gene assays, chromatin immunoprecipitation assay, real-time PCR and western blots verified a role for Cx43 in TMZ resistance. This occurred by TMZ-resistant GBM cells being able to activate epidermal growth factor receptor (EGFR). In turn, EGFR activated the JNK-ERK1/2-AP-1 axis to induce Cx43. The increased Cx43 was functional as indicated by gap junctional intercellular communication among the resistant GBM cells. Cell therapy could be a potential method to deliver drugs, such as anti-EGF to tumor cells. Similar strategies could be used to reverse the expression of Cx43 to sensitize GBM cells to TMZ. The studies showed the potential for targeting EGF in immune therapy. These agents can be used in conjunction with stem cell therapy to treat GBM

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

Glioblastoma multiforme (GBM), the most common and lethal tumor of the adult brain, generally shows chemo- and radioresistance. MicroRNAs (miRs) regulate physiological processes, such as resistance of GBM cells to temozolomide (TMZ). Although miRs are attractive targets for cancer therapeutics, the effectiveness of this approach requires targeted delivery. Mesenchymal stem cells (MSCs) can migrate to the sites of cancers, including GBM. We report on an increase in miR-9 in TMZ-resistant GBM cells. miR-9 was involved in the expression of the drug efflux transporter, P-glycoprotein. To block miR-9, methods were developed with Cy5-tagged anti-miR-9. Dye-transfer studies indicated intracellular communication between GBM cells and MSCs. This occurred by gap junctional intercellular communication and the release of microvesicles. In both cases, anti-miR-9 was transferred from MSCs to GBM cells. However, the major form of transfer occurred with the microvesicles. The delivery of anti-miR-9 to the resistant GBM cells reversed the expression of the multidrug transporter and sensitized the GBM cells to TMZ, as shown by increased cell death and caspase activity. The data showed a potential role for MSCs in the functional delivery of synthetic anti-miR-9 to reverse the chemoresistance of GBM cells

Indwelling pleural catheterization maximizes functionality and quality of life in management of recurrent malignant pleural effusions

A clinical decision report using: Davies HE, Mishra EK, Kahan BC, et al. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: The TIME2 randomized controlled trial. J Am Med Assoc. 2012;307(22):2383-2389. https://doi.org/10.1001/jama.2012.5535 for the management of recurrent malignant pleural effusions in a patient with metastatic renal cell carcinoma