The COVID‐19 Pandemic Not Only Poses Challenges, but Also Opens Opportunities for Sustainable Transformation

The COVID-19 pandemic has impacted social, economic, and environmental systems worldwide, slowing down and reversing the progress made in achieving the Sustainable Development Goals (SDGs). SDGs belong to the 2030 Agenda to transform our world by tackling humankind's challenges to ensure well-being, economic prosperity, and environmental protection. We explore the potential impacts of the pandemic on SDGs for Nepal. We followed a knowledge co-creation process with experts from various professional backgrounds, involving five steps: online survey, online workshop, assessment of expert's opinions, review and validation, and revision and synthesis. The pandemic has negatively impacted most SDGs in the short term. Particularly, the targets of SDG 1, 4, 5, 8, 9, 10, 11, and 13 have and will continue to have weakly to moderately restricting impacts. However, a few targets of SDG 2, 3, 6, and 11 could also have weakly promoting impacts. The negative impacts have resulted from impeding factors linked to the pandemic. Many of the negative impacts may subside in the medium and long terms. The key five impeding factors are lockdowns, underemployment and unemployment, closure of institutions and facilities, diluted focus and funds for non-COVID-19-related issues, and anticipated reduction in support from development partners. The pandemic has also opened a window of opportunity for sustainable transformation, which is short-lived and narrow. These opportunities are lessons learned for planning and action, socio-economic recovery plan, use of information and communication technologies and the digital economy, reverse migration and “brain gain,” and local governments' exercising authorities

Nutraceutical therapies for atherosclerosis

Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). Although the development of pharmacotherapies to treat CVD has contributed to a decline in cardiac mortality in the past few decades, CVD is estimated to be the cause of one-third of deaths globally. Nutraceuticals are natural nutritional compounds that are beneficial for the prevention or treatment of disease and, therefore, are a possible therapeutic avenue for the treatment of atherosclerosis. The purpose of this Review is to highlight potential nutraceuticals for use as antiatherogenic therapies with evidence from in vitro and in vivo studies. Furthermore, the current evidence from observational and randomized clinical studies into the role of nutraceuticals in preventing atherosclerosis in humans will also be discussed

Drivers of power line collisions and electrocutions of birds in Nepal

Abstract Among the several anthropogenic factors, power lines are increasingly regarded as one of the most significant hazards to bird species, primarily owing to collisions and electrocutions. Nepal has comparatively fewer studies on the impact of power line collisions and electrocution on birds compared with developed nations. From November 2021 to May 2022, we assessed the effect of power line collisions and electrocutions on the mortality of birds in the Putalibazar Municipality of the Syangja district of Nepal. We established 117 circular plots in diverse habitats, including agricultural lands, forests, settlements, and river basins, along a 30.6 km long distribution line. Within 18 plots, we detected 43 fatalities of 11 species (17 individuals of six species due to collision and 26 individuals of eight species due to electrocution). House Swift (Apus nipalensis) and Common Myna (Acridotheres tristis) were the primary victims of the collision, whereas House Crow (Corvus splendens) and Rock Pigeon (Columba livia) were frequently observed electrocuted. We also recorded the electrocution of the critically endangered White‐rumped Vulture (Gyps bengalensis). The total rate of bird power line collisions per kilometer was 0.55 birds, while the total electrocution rate per 10 poles was 2.22. The bird abundance, distance to agricultural regions, and proximity to human settlements were found to have a strong relationship with the mortality of birds caused by power lines. In order to reduce power line collisions and electrocution fatalities, we recommend conducting a detailed bird population study prior to determining the route of distribution lines

Factors Influencing the Potential Distribution of Globally Endangered Egyptian Vulture Nesting Habitat in Nepal

Habitat suitability is crucial to ensure the long-term persistence of species and can be identified based on relationships between species occurrences and underlying abiotic and biotic factors. We identified potential nesting habitat for the Egyptian vulture (Neophron percnopterus) in Nepal using ecological niche modeling with climatic variables. We estimated the currently suitable nesting habitat for Egyptian vulture in Nepal at 38,204 km2. We found a high probability of suitable nesting habitat on east-facing aspects, and the probability of a suitable nesting habitat was greater in more mountainous areas, particularly in central and western regions of Nepal. Precipitation was a major factor for predicting probability of the presence of nest sites for Egyptian vultures. After identifying potentially suitable habitat, we identified environmental factors affecting landscape-level suitable nesting habitat for Egyptian vultures using generalized linear models. For Egyptian vultures, sites near forests and human settlements were most suitable for nesting, roosting, and foraging, especially in central and western Nepal. Based on potentially suitable nesting habitat and previous work on Egyptian vulture foraging and roosting habitat, we recommend protecting forests near water sources and open areas for their long-term conservation

Alarming rates of antimicrobial resistance and fungal sepsis in outborn neonates in North India

<div><p>Background</p><p>There is a paucity of data on the epidemiology of sepsis in outborn neonates being referred to level-3 units in low- and middle-income countries (LMIC). The objective of the present study was to evaluate the prevalence of sepsis and outcomes of outborn neonates with sepsis, and to characterize the pathogen profile and antimicrobial resistance (AMR) patterns of common isolates in them.</p><p>Methods</p><p>In this prospective observational cohort study (2011–2015), a dedicated research team enrolled all neonates admitted to an outborn level-3 neonatal unit and followed them until discharge/death. Sepsis work-up including blood culture(s) was performed upon suspicion of sepsis. All the isolates were identified and tested for antimicrobial susceptibility. Gram-negative pathogens resistant to any three of the five antibiotic classes (extended-spectrum cephalosporins, carbapenems, aminoglycosides, fluoroquinolones, and piperacillin-tazobactam) were labeled multi-drug resistant.</p><p>Results</p><p>Of the total of 2588 neonates enrolled, culture positive sepsis and total sepsis–i.e. culture positive and/or culture negative sepsis–was diagnosed in 13.1% (95% CI 11.8% to 14.5%) and 54.7% (95% CI 52.8% to 56.6%), respectively. The case fatality rates were 23.4% and 11.0% in culture-positive and total sepsis, respectively. Sepsis accounted for two-thirds of total neonatal deaths (153/235, 63.0%). Bacterial isolates caused about three-fourths (296/401; 73.8%) of the infections. The two common pathogens–<i>Klebsiella pneumoniae</i> (n = 50, 12.5%) and <i>Acinetobacter baumannii</i> (n = 46, 11.5%)–showed high degree of multi-drug resistance (78.0% and 91.3%, respectively) and carbapenem resistance (84.0% and 91.3%, respectively). About a quarter of infections were caused by Candida spp. (n = 91; 22.7%); almost three-fourths (73.7%) of these infections occurred in neonates born at or after 32 weeks’ gestation and about two-thirds (62.1%) in those weighing 1500 g or more at birth.</p><p>Conclusions</p><p>In this large outborn cohort, we report high burden of sepsis, high prevalence of systemic fungal infections, and alarming rates of antimicrobial resistance among bacterial pathogens.</p></div

Demographic characteristics of enrolled infants.

<p>Demographic characteristics of enrolled infants.</p

Profile of clinical isolates^*.

<p>Profile of clinical isolates^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180705#t004fn002" target="_blank">*</a>}.</p