371 research outputs found
cyTRON and cyTRON/JS: two Cytoscape-based applications for the inference of cancer evolution models
The increasing availability of sequencing data of cancer samples is fueling
the development of algorithmic strategies to investigate tumor heterogeneity
and infer reliable models of cancer evolution. We here build up on previous
works on cancer progression inference from genomic alteration data, to deliver
two distinct Cytoscape-based applications, which allow to produce, visualize
and manipulate cancer evolution models, also by interacting with public genomic
and proteomics databases. In particular, we here introduce cyTRON, a
stand-alone Cytoscape app, and cyTRON/JS, a web application which employs the
functionalities of Cytoscape/JS.
cyTRON was developed in Java; the code is available at
https://github.com/BIMIB-DISCo/cyTRON and on the Cytoscape App Store
http://apps.cytoscape.org/apps/cytron. cyTRON/JS was developed in JavaScript
and R; the source code of the tool is available at
https://github.com/BIMIB-DISCo/cyTRON-js and the tool is accessible from
https://bimib.disco.unimib.it/cytronjs/welcome
A novel universal primer pair for prokaryotes with improved performances for anammox containing communities
Long-term effects of mineral precipitation on process performance, granules' morphology and microbial community in anammox granular sludge
Diet, Environments, and Gut Microbiota. A Preliminary Investigation in Children Living in Rural and Urban Burkina Faso and Italy.
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and Rural Africa
peer reviewe
Understanding the Ultra-Rare Disease Autosomal Dominant Leukodystrophy: an Updated Review on Morpho-Functional Alterations Found in Experimental Models
Autosomal dominant leukodystrophy (ADLD) is an ultra-rare, slowly progressive, and fatal neurodegenerative disorder associated with the loss of white matter in the central nervous system (CNS). Several years after its first clinical description, ADLD was found to be caused by coding and non-coding variants in the LMNB1 gene that cause its overexpression in at least the brain of patients. LMNB1 encodes for Lamin B1, a protein of the nuclear lamina. Lamin B1 regulates many cellular processes such as DNA replication, chromatin organization, and senescence. However, its functions have not been fully characterized yet. Nevertheless, Lamin B1 together with the other lamins that constitute the nuclear lamina has firstly the key role of maintaining the nuclear structure. Being the nucleus a dynamic system subject to both biochemical and mechanical regulation, it is conceivable that changes to its structural homeostasis might translate into functional alterations. Under this light, this review aims at describing the pieces of evidence that to date have been obtained regarding the effects of LMNB1 overexpression on cellular morphology and functionality. Moreover, we suggest that further investigation on ADLD morpho-functional consequences is essential to better understand this complex disease and, possibly, other neurological disorders affecting CNS myelination
T2* heterogeneity detected by CMR could be related to myocardial iron distribution in Thalassemia patients
Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside
Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain. They generate different lipid mediators, such as diacylglycerol, phosphatidic acid, lysophosphatidic acid, and arachidonic acid, representing key elements of intra- and inter-cellular signaling and being involved in the regulation of several cellular mechanisms that can promote tumor progression and aggressiveness. In this review, it is summarized the current knowledge about the role of phospholipases in brain tumor progression, focusing on low- and high-grade gliomas, representing promising prognostic or therapeutic targets in cancer therapies due to their influential roles in cell proliferation, migration, growth, and survival. A deeper understanding of the phospholipases-related signaling pathways could be necessary to pave the way for new targeted therapeutic strategies
Significant and Conflicting Correlation of IL-9 With Prevotella and Bacteroides in Human Colorectal Cancer
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