Interaction of picolinic acid N-oxide and its derivatives with cobalt(II) involving some selected ligands in aqueous medium

792-794The formation constants of 1:1 binary chelates (ML of Co(II) with (L) picolinic acid N-oxide (Pico) and its derivatives 4-aminopicolinic acid N-oxide (4-NH2 Pico), 4-chloropicolinic acid N-oxide (4-Cl Pico) and 4-hydroxypicolinic acid N-oxide (4-OH Pico) and the corresponding 1:1:1 ternary chelates (MAL or MLA) involving (A) glycine, proline (N, O- donors); ethylenediamine, 1,10-phenanthroline (N,N donors); catechol, salicylic acid (O-,O- donors) and thioglycolic acid (S, O- donor) have been determined from pHmetric measurements at 30°C and 0.1 M (KNO3) ionic strength in aqueous medium. The stabilities of the binary chelates (ML) follow the order: 4-Cl Pico 2 Pica, while those of ternary complexes show a quite reverse trend. The relative stabilities of the ternary complexes are quantitatively expressed in terms of the statistical parameter, D log K. The results are discussed in the light of statistical and different astatistical factors. The thermodynmic parameters determined for the binary systems are found to be favourable for chelation

INSIGHT OF METHANOLIC EXTRACT OF VENTILAGO MADERASPATANA LEAVES ON HEPATOPROTECTIVE ACTIVITY UNDER STREPTOZOTOCIN-INDUCED DIABETIC RATS

Objective: The methanolic leaf extract of Ventilago maderaspatana (MEVML, 200 mg/kg body weight [b.w.]) was investigate to hepatoprotective activity under streptozotocin-induced (45 mg/kg b.w.) diabetic (Di) rats. Methods: In the present study, we determined the blood glucose levels, b.w., insulin, creatinine, and bilirubin levels in normal, Di, Di treated with MEVML and positive control rats. Results: The Di rats shown adverse changes in blood glucose levels, b.w., insulin, creatinine, and bilirubin levels when compared to other group rats. Reverse the adverse changes in the above parameters when treated the Di rats with MEVML Conclusion: The MEVML shown anti-diabetic activity and reverse the adverse changes in the above parameters in liver so that the MEVML supported the traditional claim of the hepatoprotective activity under Di condition

Improvement of Voltage Profile through the Optimal Placement of FACTS Using L-Index Method

In this paper an IEEE standard test system is considered and it is tested using Newton-Raphson method with the help of MATLAB. The voltage magnitudes of each bus are examined and the corresponding weak bus is incorporated with FACTS such as SVC and TCSC. The optimal placement of FACTS can be identified using L-Index method. The value of L-index which approach unity implies that it reaches to instability. From this instability point the system stability is improved during steady state and Fault conditions. The disturbance is created in the system by changing the Load Reactive Power at a particular Bus.DOI:http://dx.doi.org/10.11591/ijece.v4i2.513

DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE MUCOADHESIVE MICROBEADS CONTAINING SIMVASTATIN WITH DIFFERENT CROSS LINKING AGENTS

Objective: The aim of the present work was to prepare and examine drug release of the oral controlled release microbeads using different curing agents by emulsification internal ionic gelation technique. Methods: Cross-linked alginate microbeads were prepared with different cross linking agents by using mucoadhesive properties. The formation and compatibility of microbeads were confirmed by compatibility studies. Prepared microbeads evaluated for encapsulated efficiency, micromeritic properties, drug loading, in vitro wash off studies, in vitro dissolution studies, drug release kinetics and stability studies Results: The in vitro drug release was influenced by both type of curing agents and type of polymers and no significant changes in characterization parameters was observed after 3 mo stability studies. The sustained release profile of optimized batch was found to be 99.66±0.18% in comparison to pure drug profile of 28.64±0.02% at 12 h release study. Results of both wash-off and in vitro studies suggests that batch (SF2) prepared with aluminium chloride has shown better mucoadhesive property. Drug release of optimized batch follows zero order with non fickian mechanism according to Korsmeyer-Peppas equation. Conclusion: The data suggest the use of simvastatin mucoadhesive cross linked microbeads to offer the potential for oral controlled drug delivery with improved gastric retention and capable to provide sustained drug release by using cross linking agents

Nanocrystalline Pb(Zr 0.52

Nanocrystalline powders of the composition Pb(Zr0.52Ti0.48)O3 were obtained by Mechanical alloying (high-energy ball milling). X-ray diffraction studies show that these compounds are completely into the perovskite phase. Detailed studies of electrical and mechanical properties of PZT as a function of temperature (and frequency) showed the high permittivity of 20653 at Curie transition temperature. Temperature variation of longitudinal modulus and internal friction of these ceramics at 104 kHz frequency were studied in the wide temperature range of 30∘C–420∘C. The internal friction measurements showed sharp stress induced relaxation peaks in the present composition corresponding to those temperatures where the minima were noticed in temperature variation of longitudinal modulus behavior. This dielectric and internal friction behaviour was explained in the light of polaron hopping mechanism and structural phase transitions in the present piezoelectric compositions

A comparative study on placebo and trenaxamic acid for the prophylaxis is of post-partum hemorrhage: a randomised double-blind control study

Background: Obstetric haemorrhage accounts for 20-25% of maternal mortality and morbidity. Anti-fibrinolytics are being widely used in field of surgery. It is also used to reduce heavy menstrual blood loss. The aim of this study was to analyse the effectiveness of TXA in reducing blood loss during normal vaginal delivery.Methods: The randomized double-blind control study was done in the Labour ward. It was conducted on 100 women undergoing Normal vaginal delivery. They were allocated to either Study or Control group by randomization. TXA was given during the Third stage of delivery in study group in addition to the routine care whereas the control group had routine care alone. Blood loss was measured in both groups by bag method.Results: The significant of reduction in blood loss calculated from placental delivery to 2hrs. 141.9 ml in study group versus 270.4 ml in control group. Among primi patients, the control group average blood loss was 325ml, the study group avg blood loss was 169ml. Among G2 patients, the control group average blood loss was 248.5ml. The study group average blood loss was 128.25ml. Among G3 patients, the control group average blood loss was 203ml, the study group average blood loss was 115ml.Conclusions: TXA significantly reduced the amount of blood loss during normal vaginal delivery. Thus, TXA can be used safely and effectively in subjects undergoing normal vaginal delivery

Panorama of neoplasms of upper GI tract: a 5 year research study

Background: The diseases of the gastrointestinal tract (GIT) are the most common and leading cause of morbidity and mortality than the disorders of any other systems of the body. Gastrointestinal (GI) tract tumors are one of the most common cancers accounting for 11% of all cancers. Among these tumors, upper gastrointestinal tract malignancies are quite aggressive with a dismal prognosis. Malignant tumors are most common than benign. The most common carcinoma of the esophagus is Squamous cell carcinoma (SCC). Incidence of SCC is less than 5 per 100,000 populations in males and 1 per 100,000 populations in females. Gastric cancer was the second most common cancer in the World and 60% of them occurred in developing countries. The most common carcinoma of the Stomach is Adenocarcinoma.Aim & Objectives: To study the spectrum of neoplastic lesions of the upper gastrointestinal tract by the examination of endoscopic biopsies and surgically resected specimens. To determine the degree of severity of the malignancies by assessing the depth of invasion, Lymph nodal & Omental spread.Methods: The present study is both retrospective & prospective study for a period of 5 years from January 2007 to December 2011. The sample size includes all the endoscopic biopsies & surgically resected specimens of gastrointestinal tract received at Department of Pathology, S.V. Medical College, Tirupati. The study also obtained clearance from the ethical committee of the institution. The biopsy specimens thus obtained were fixed in 10% buffered neutral formalin. The sections were stained routinely with H & E. Special stains and IHC done wherever necessary.Results: we have received 120 specimens regarding the upper gastrointestinal system. Among these 120 specimens, 71 specimens were endoscopic biopsies & 49 specimens were surgically resected specimens. Out of 71 Endoscopic biopsies 28 biopsies were malignant among which 2 was esophagus and 26 were stomach. Out of 49 surgically resected specimens 1 was benign and 32 were malignant tumors. Out of 59 neoplasms of stomach there were single cases each of Sub mucosal Lipoma, Malignant lymphoma, GIST & 56 cases of Adenocarcinoma & its variants were noted.Conclusion: Most of the neoplasms are of stomach (97%). All the neoplasms are malignant except one benign lesion sub mucous lipoma of stomach. Most of the neoplasms of stomach were Adenocarcinoma (96.5%). Both tumors of esophagus were squamous cell carcinoma occurred after 50 years of age.

Ferromagnetic-Dielectric Ni 0.5Z

Novel ferromagnetic-dielectric particulate composites of Ni0.5Zn0.5Fe1.95O4−δ (NZF) and PbZr0.52Ti0.48O3 (PZT) were prepared by conventional ceramic method. The presence of two phases in composites was confirmed by XRD technique. The variations of dielectric constant () with frequency in the range of 100 kHz–1 MHz at room temperature and also with temperature at three different frequencies (50 kHz, 100 kHz, and 500 kHz) were studied. Detailed studies on the dielectric properties were done confirming that the magnetoelectric interaction between the constituent phases may result in various anomalies in the dielectric behaviour of the composites. It is proposed that interfaces play an important role in the dielectric properties, causing space charge effects and Maxwell-Wagner relaxation, particularly at low frequencies and high temperatures. The piezoelectric d33 constant was studied at room temperature, and the d33 constant value decreased with ferrite content. Magnetic properties like B-H loops traces were studied to understand the saturation magnetic (Ms) and magnetic moment () of the present particulate composites. The magnetoelectric (ME) output was measured by varying dc bias magnetic field. A large ME output signal of 2780 mV/cm Oe was observed in the composite having 50% ferrite. The temperature variation of longitudinal modulus (L) and internal friction (Q−1) of these particulate composites at 104 kHz was studied in the temperature range 30°C–420°C by the composite oscillator technique. Longitudinal modulus showed a sharp minimum, and internal friction exhibits a sharp peak at ferroelectric-paraelectric phase transition. These ferroelectric-dielectric particulate composites were prepared with a view to using them as ME sensors and transducers