Biodegradable dendrimer functionalized carbon nanotube-hybrids for biomedical applications

In the present study, biodegradable poly(amidoamine) dendrimers (PAMAM G1/G2/G3) was covalently functionalized with carbon nanotubes (CNTs) and nanostructured hydroxyapatite was immobilized onto CNTs-PAMAM matrix through coordination bond between the -NH2 groups of dendrimer and Ca2+ of hydroxyapatite. The structural and morphological behaviors of the nanohybrids were established through spectroscopic and microscopic analyses. In vitro cytotoxicity and cell proliferation was assessed through osteoblast-like MG 63 cell line using 3-4, 5-dimethylthiazole-2-yl, 2,5-diphenyl tetrazolium bromide assay for 3days. The more abundant of -NH2 group exist in PAMAM(G3) dendrimer attracts more number of HAp molecules onto their surface which exhibits enhanced activity in cell proliferations even at higher concentrations

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and healing. Hence, in this study, biocompatible polymers functionalized with CNTs and then synthetic bone minerals i.e. hydroxyapatite has been stabilized onto CNTs-polymer matrixes. Structural morphology of the materials was analyzed by spectroscopic/microscopic analyses. The cytotoxic property of nanohybrids was examined on osteoblast-like MG-63 cells. The lack of significant cytotoxic effect of nanohybrids suggested that the nanohybrids are considered as promising candidates for bone tissue engineering applications