Impact of 2004 Tsunami in the Islands of Indian Ocean: Lessons Learned

Tsunami of 2004, caused by a 9.0 magnitude earthquake, is the most devastating tsunami in modern times, affecting 18 countries in Southeast Asia and Southern Africa, killing more than 250,000 people in a single day, and leaving more than 1.7 million homeless. However, less reported, albeit real, is its impact in the islands of the Indian Ocean more than 1,000 miles away from its epicenter. This is the first peer-reviewed paper on the 2004 tsunami events specifically in the eleven nations bordering the Indian Ocean, as they constitute a region at risk, due to the presence of tectonic interactive plate, absence of a tsunami warning system in the Indian Ocean, and lack established communication network providing timely information to that region. Our paper has a dual objective: the first objective is to report the 2004 tsunami event in relation to the 11 nations bordering the Indian Ocean. The second one is to elaborate on lessons learned from it from national, regional, and international disaster management programs to prevent such devastating consequences of tsunami from occurring again in the future

L’utilisation de la lutte chimique et de la résistance variétale contre le mildiou de la pomme de terre à Madagascar

La culture de la pomme de terre (Solanum tuberosum L.) au Madagascar a sévèrement été affectée par l’épidémie du mildiou (Phytophtora infestans) au cours des années 2007 - 2008. La plupart des variétés étaient  affectées, ce qui fait appel à l’évaluation des produits anti-mildiou et la résistance au sein des germoplasmes dans le pays. Cette étude avait pour objectif de déterminer l’efficacité des fongicides en terme de capacité protectrice et systémique, ainsi que la résistance inhérente de quelques variétés cultivées au Madagascar. Parmi les produits testés, le mélange des fongicides protecteurs et systémiques ont été les plus efficaces et plus économiquement bénéfiques. Les meilleurs traitements étaient 1.5 kg ha-1 de dithane à base de mancozèbe plus 1.5 kg ha-1 d-athlète à base de fosétylaluminium, et 1.5 kg ha-1 de dithane plus 1.5 kg ha-1 de ridomil à base de metalaxyl plus le manèbe. L’application de ces produits a donné un rapport bénéfice-coût de 3. Les variétés qui ont manifesté unerésistance considérable sont entre autre CIP 395 015.6, CIP 395 111.13 et CIP 396 236.20, toutes avec un rendement >20 t ha-1. Cependant, leurs niveaux de résistance nécessitent un suivi régulier.Mots Clés: Clones, fongicide, mildiou, pomme de terr

The impact of integrated infant and young child feeding and micronutrient powder intervention on feeding practices and anemia in children aged 6-23 months in Madagascar

This study assesses the impact of an integrated infant and young child feeding (IYCF) and micronutrient powder (MNP) intervention on children's risk of anemia and IYCF practices in Madagascar. Quantitative baseline and endline surveys were conducted in representative households with children 6-23 months from two districts, where an 18-month IYCF-MNP intervention was implemented. Relative risks comparing children's risk of anemia and maternal IYCF knowledge and practices at baseline versus endline, and also at endline among MNP-users versus non-users were estimated using log-binomial regression models. 372 and 475 children aged 6-23 months were assessed at baseline and endline respectively. Prevalence of anemia fell from 75.3% to 64.9% from baseline to endline (p = 0.002); the reduction in the risk of anemia remained significant in models adjusting for sociodemographic characteristics (ARR (95% CI): 0.86 (0.78, 0.95), p = 0.003). In endline assessments, 229 out of 474 (48.3%) of children had consumed MNPs. MNP-users had a lower risk of anemia (ARR (95% CI): 0.86 (0.74, 0.99), p = 0.04) than non-users, after controlling for child's dietary diversity and morbidity, maternal counseling by community-health-workers, and sociodemographic characteristics. Mothers interviewed at endline also had greater nutrition knowledge and were more likely to feed their children ≥4 food groups (ARR (95% CI): 2.92 (2.24, 3.80), p < 0.001), and the minimum acceptable diet (ARR (95% CI): 2.88 (2.17, 3.82), p < 0.001) than mothers interviewed at baseline. Integration of MNP into IYCF interventions is a viable strategy for improving children's consumption of micronutrients and reducing risk of anemia. The addition of MNP does not negatively impact, and may improve, IYCF practices.We are grateful to all of the mothers and children and participating communities, as well as data enumerators, and the USAID-supported SALOHI project team for the technical and financial support during the baseline and endline surveys. We also thank Jacky Raharinjatovo the PSI-Madagascar statistician for support in analyses as well as Roland Kupka, France Begin and Jennifer Marcy for their comments and feedback on this manuscript. The views expressed in this manuscript are those of the authors and do not necessarily reflect the official positions or policies of their affiliated institutions. Both the baseline and the endline surveys were funded by USAID/SALOHI. (USAID; USAID/SALOHI)Published versio

Cartographie des systèmes rizicoles du Lac Alaotra (Madagascar)

La cuvette du Lac Alaotra est le «grenier à riz» de Madagascar. Le milieu physique y est très diversifié, naturellement et par suite de l'intervention humaine. Une cartographie des types d'exploitation de ce milieu a été entreprise à l'aide de scènes SPOT. Elle vient en appui aux actions menées en commun par la recherche agronomique et les acteurs du développement

8-vinyl-deoxyadenosine, an alternative fluorescent nucleoside analog to 2′-deoxyribosyl-2-aminopurine with improved properties

We report here the synthesis and the spectroscopic characterization of 8-vinyl-deoxyadenosine (8vdA), a new fluorescent analog of deoxyadenosine. 8vdA was found to absorb and emit in the same wavelength range as 2′-deoxyribosyl-2-aminopurine (2AP), the most frequently used fluorescent nucleoside analog. Though the quantum yield of 8vdA is similar to that of 2AP, its molar absorption coefficient is about twice, enabling a more sensitive detection. Moreover, the fluorescence of 8vdA was found to be sensitive to temperature and solvent but not to pH (around neutrality) or coupling to phosphate groups. Though 8vdA is base sensitive and susceptible to depurination, the corresponding phosphoramidite was successfully prepared and incorporated in oligonucleotides of the type d(CGT TTT XNX TTT TGC) where N = 8vdA and X = A, T or C. The 8vdA-labeled oligonucleotides gave more stable duplexes than the corresponding 2AP-labeled sequences when X = A or T, indicating that 8vdA is less perturbing than 2AP and probably adopts an anti conformation to preserve the Watson–Crick H-bonding. In addition, the quantum yield of 8vdA is significantly higher than 2AP in all tested oligonucleotides in both their single strand and duplex states. The steady-state and time-resolved fluorescence parameters of 8vdA and 2AP were found to depend similarly on the nature of their flanking residues and on base pairing, suggesting that their photophysics are governed by similar mechanisms. Taken together, our data suggest that 8vdA is a non perturbing nucleoside analog that may be used with improved sensitivity for the same applications as 2AP

Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer

Synthesis of the HIV-1 viral DNA by reverse transcriptase involves two obligatory strand transfer reactions. The second strand transfer corresponds to the annealing of the (−) and (+) DNA copies of the primer binding site (PBS) sequence which is chaperoned by the nucleocapsid protein (NCp7). NCp7 modifies the (+)/(−)PBS annealing mechanism by activating a loop–loop kissing pathway that is negligible without NCp7. To characterize in depth the dynamics of the loop in the NCp7/PBS nucleoprotein complexes, we investigated the time-resolved fluorescence parameters of a (−)PBS derivative containing the fluorescent nucleoside analogue 2-aminopurine at positions 6, 8 or 10. The NCp7-directed switch of (+)/(−)PBS annealing towards the loop pathway was associated to a drastic restriction of the local DNA dynamics, indicating that NCp7 can ‘freeze’ PBS conformations competent for annealing via the loops. Moreover, the modifications of the PBS loop structure and dynamics that govern the annealing reaction were found strictly dependent on the integrity of the zinc finger hydrophobic platform. Our data suggest that the two NCp7 zinc fingers are required to ensure the specificity and fidelity of the second strand transfer, further underlining the pivotal role played by NCp7 to control the faithful synthesis of viral HIV-1 DNA

Risk stratification for arrhythmic death in an emergency department cohort: a new method of nonlinear PD2i analysis of the ECG

Heart rate variability (HRV) reflects both cardiac autonomic function and risk of sudden arrhythmic death (AD). Indices of HRV based on linear stochastic models are independent risk factors for AD in postmyocardial infarction (MI) cohorts. Indices based on nonlinear deterministic models have a higher sensitivity and specificity for predicting AD in retrospective data. A new nonlinear deterministic model, the automated Point Correlation Dimension (PD2i), was prospectively evaluated for prediction of AD. Patients were enrolled (N = 918) in 6 emergency departments (EDs) upon presentation with chest pain and being determined to be at risk of acute MI (AMI) >7%. Brief digital ECGs (>1000 heartbeats, ∼15 min) were recorded and automated PD2i results obtained. Out-of-hospital AD was determined by modified Hinkle-Thaler criteria. All-cause mortality at 1 year was 6.2%, with 3.5% being ADs. Of the AD fatalities, 34% were without previous history of MI or diagnosis of AMI. The PD2i prediction of AD had sensitivity = 96%, specificity = 85%, negative predictive value = 99%, and relative risk >24.2 (p ≤ 0.001). HRV analysis by the time-dependent nonlinear PD2i algorithm can accurately predict risk of AD in an ED cohort and may have both life-saving and resource-saving implications for individual risk assessment