177 research outputs found
Portable near infrared spectroscopy for the isomeric differentiation of new psychoactive substances
Electron-correlation effects in appearance-potential spectra of Ni
Spin-resolved and temperature-dependent appearance-potential spectra of
ferromagnetic Nickel are measured and analyzed theoretically. The Lander
self-convolution model which relates the line shape to the unoccupied part of
the local density of states turns out to be insufficient. Electron correlations
and orbitally resolved transition-matrix elements are shown to be essential for
a quantitative agreement between experiment and theory.Comment: LaTeX, 6 pages, 2 eps figures included, Phys. Rev. B (in press
Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs.
Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is therefore an important part of the phenotype. Nevertheless, it has not yet been examined to what extent individuals sharing part of their genome and/or environment indeed have similar metabolomes. Here we present the results of hierarchical clustering of blood plasma lipid profile data obtained by liquid chromatographymass spectrometry from 23 healthy, 18-year-old twin pairs, of which 21 pairs were monozygotic, and 8 of their siblings. For 13 monozygotic twin pairs, within-pair similarities in relative concentrations of the detected lipids were indeed larger than the similarities with any other study participant. We demonstrate such high coclustering to be unexpected on basis of chance. The similarities between dizygotic twins and between nontwin siblings, as well as between nonfamilial participants, were less pronounced. In a number of twin pairs, within-pair dissimilarity of lipid profiles positively correlated with increased blood plasma concentrations of C-reactive protein in one twin. In conclusion, this study demonstrates that in healthy individuals, the individual genetic background contributes to the blood plasma lipid profile. Furthermore, lipid profiling may prove useful in monitoring health status, for example, in the context of personalized medicine. © 2008 Mary Ann Liebert, Inc. Chemicals / CAS: C-Reactive Protein, 9007-41-4; Lipid
Theory of Spin-Resolved Auger-Electron Spectroscopy from Ferromagnetic 3d-Transition Metals
CVV Auger electron spectra are calculated for a multi-band Hubbard model
including correlations among the valence electrons as well as correlations
between core and valence electrons. The interest is focused on the
ferromagnetic 3d-transition metals. The Auger line shape is calculated from a
three-particle Green function. A realistic one-particle input is taken from
tight-binding band-structure calculations. Within a diagrammatic approach we
can distinguish between the \textit{direct} correlations among those electrons
participating in the Auger process and the \textit{indirect} correlations in
the rest system. The indirect correlations are treated within second-order
perturbation theory for the self-energy. The direct correlations are treated
using the valence-valence ladder approximation and the first-order perturbation
theory with respect to valence-valence and core-valence interactions. The
theory is evaluated numerically for ferromagnetic Ni. We discuss the
spin-resolved quasi-particle band structure and the Auger spectra and
investigate the influence of the core hole.Comment: LaTeX, 12 pages, 8 eps figures included, Phys. Rev. B (in press
Absence of Metallization in Solid Molecular Hydrogen
Being the simplest element with just one electron and proton the electronic
structure of the Hydrogen atom is known exactly. However, this does not hold
for the complex interplay between them in a solid and in particular not at high
pressure that is known to alter the crystal as well as the electronic
structure. Back in 1935 Wigner and Huntington predicted that at very high
pressure solid molecular hydrogen would dissociate and form an atomic solid
that is metallic. In spite of intense research efforts the experimental
realization, as well as the theoretical determination of the crystal structure
has remained elusive. Here we present a computational study showing that the
distorted hexagonal P6/m structure is the most likely candidate for Phase
III of solid hydrogen. We find that the pairing structure is very persistent
and insulating over the whole pressure range, which suggests that metallization
due to dissociation may precede eventual bandgap closure. Due to the fact that
this not only resolve one of major disagreement between theory and experiment,
but also excludes the conjectured existence of phonon-driven superconductivity
in solid molecular hydrogen, our results involve a complete revision of the
zero-temperature phase diagram of Phase III
Low-Temperature Equation of State of Molecular Hydrogen and Deuterium to 0.37 Mbar: Implications for Metallic Hydrogen
Response to Therapeutic Sleep Deprivation: A Naturalistic Study of Clinical and Genetic Factors and Post-treatment Depressive Symptom Trajectory
Research has shown that therapeutic sleep deprivation (SD) has rapid antidepressant effects in the majority of depressed patients. Investigation of factors preceding and accompanying these effects may facilitate the identification of the underlying biological
mechanisms. This exploratory study aimed to examine clinical and genetic factors predicting response to SD and determine the impact of SD on illness course. Mood during SD was also assessed via visual analogue scale. Depressed inpatients (n = 78) and healthy controls (n = 15) underwent ~36 h of SD. Response to SD was defined as a score of ≤ 2 on the Clinical Global Impression
Scale for Global Improvement. Depressive symptom trajectories were evaluated for up to a month using self/expert ratings. Impact of genetic burden was calculated using polygenic risk scores for major depressive disorder. In total, 72% of patients responded to SD. Responders and non-responders did not differ in baseline self/expert depression symptom ratings, but mood differed. Response was associated with lower age (p = 0.007) and later age at life-time disease onset (p = 0.003). Higher genetic burden of depression
was observed in non-responders than healthy controls. Up to a month post SD, depressive symptoms decreased in both patients groups, but more in responders, in whom effects were sustained. The present findings suggest that re-examining SD with a greater focus on biological mechanisms will lead to better understanding of mechanisms of depression
Quantitative assessment of parkinsonian bradykinesia based on an inertial measurement unit
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