Hazards of sea level rise and dams built on the River Nile on water budget and salinity of the Nile Delta aquifer

Data availability: No data was used for the research described in the article.Code availability: Upon request.Supplementary material is available online at: https://www.sciencedirect.com/science/article/pii/S2214581823002872#sec0135 .Copyright © 2023 The Authors. Study region: The Nile Delta region consists of flat, low-lying areas, where most areas are used for agriculture. It covers an area of 22,000 km2, which is 2.20% of the total area of Egypt. Study focus: This study evaluates the water budget and the salinity due to the Sea Level Rise (SLR) and the reduction in the river water flow caused by the Grand Ethiopian Renaissance Dam (GERD) using the numerical code SEAWAT. Three filling scenarios were considered for the GERD reservoir at elevations 600 m, 621 m, and 645 m above mean sea level (AMSL) for the storage volumes of 17 billion cubic meters (BCM) (scenarios #1), 37.30 BCM (scenarios #2), and 74 BCM (scenarios #3). The impact of these fillings scenarios was combined with SLR of 25 cm, and increasing the abstraction rates from the Nile Delta aquifer by 25%, 50%, and 100%, respectively. New hydrological insights for the region: The study findings indicated that the SLR and the GERD reservoir filling with increasing pumping rates, especially during the filling periods, would influence the groundwater resources in the Nile Delta. The GERD reservoir filling could alter the freshwater, in which the aquifer salinity increased by 4.47%, 11.48%, and 29.99% for the three scenarios, respectively. The methodology and findings presented in this study might be useful for investing and comparing the impact of SLR and upstream dam projects on the downstream water budget and salinity at other coastal regions.Alban Kuriqi is grateful for the Foundation for Science and Technology's support through funding UIDB/04625/2020 from the research unit CERIS

Current and prospective pharmacological targets in relation to antimigraine action

Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT2 receptor antagonists, Ca2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT1-7), adrenergic (α1, α2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP2), adenosine (A1, A2, and A3), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon

An internet of things and blockchain based smart campus architecture

Rapid development in science and information technologies, such as the Internet of things, has led to a growth in the number of studies and research papers on smart cities in recent years and more specifically on the construction of smart campus technologies. This paper will review the concept of a smart campus, discuss the main technologies deployed, and then propose a new novel framework for a smart campus. The architecture of this new smart campus approach will be discussed with particular consideration of security and privacy systems, the Internet of things, and blockchain technologies

Light regulation of metabolic pathways in fungi

Light represents a major carrier of information in nature. The molecular machineries translating its electromagnetic energy (photons) into the chemical language of cells transmit vital signals for adjustment of virtually every living organism to its habitat. Fungi react to illumination in various ways, and we found that they initiate considerable adaptations in their metabolic pathways upon growth in light or after perception of a light pulse. Alterations in response to light have predominantly been observed in carotenoid metabolism, polysaccharide and carbohydrate metabolism, fatty acid metabolism, nucleotide and nucleoside metabolism, and in regulation of production of secondary metabolites. Transcription of genes is initiated within minutes, abundance and activity of metabolic enzymes are adjusted, and subsequently, levels of metabolites are altered to cope with the harmful effects of light or to prepare for reproduction, which is dependent on light in many cases. This review aims to give an overview on metabolic pathways impacted by light and to illustrate the physiological significance of light for fungi. We provide a basis for assessment whether a given metabolic pathway might be subject to regulation by light and how these properties can be exploited for improvement of biotechnological processes

Italian guidelines for primary headaches: 2012 revised version

The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in adults was published in J Headache Pain 2(Suppl. 1):105–190 (2001). Ten years later, the guideline committee of the Italian Society for the Study of Headaches (SISC) decided it was time to update therapeutic guidelines. A literature search was carried out on Medline database, and all articles on primary headache treatments in English, German, French and Italian published from February 2001 to December 2011 were taken into account. Only randomized controlled trials (RCT) and meta-analyses were analysed for each drug. If RCT were lacking, open studies and case series were also examined. According to the previous edition, four levels of recommendation were defined on the basis of levels of evidence, scientific strength of evidence and clinical effectiveness. Recommendations for symptomatic and prophylactic treatment of migraine and cluster headache were therefore revised with respect to previous 2001 guidelines and a section was dedicated to non-pharmacological treatment. This article reports a summary of the revised version published in extenso in an Italian version