1,463 research outputs found

    Role of cannabinoids in the regulation of bone remodeling

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    The endocannabinoid system plays a key role in regulating a variety of physiological processes such as appetite control and energy balance, pain perception, and immune responses. Recent studies have implicated the endocannabinoid system in the regulation of bone cell activity and bone remodelling. These studies showed that endogenous cannabinoid ligands, cannabinoid receptors and the enzymes responsible for ligand synthesis and breakdown all play important roles in bone mass and in the regulation of bone disease. These findings suggest that the endocannabinoid pathway could be of value as a therapeutic target for the prevention and treatment of bone diseases. Here, we review the role of the skeletal endocannabinoid system in the regulation of bone remodelling in health and disease

    Signatures of Pseudoscalar Photon Mixing in CMB Radiation

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    We model the effect of photon and ultra-light pseudoscalar mixing on the propagation of electromagnetic radiation through the extragalactic medium. The medium is modelled as a large number of magnetic domains, uncorrelated with one another. We obtain an analytic expression for the different Stokes parameters in the limit of small mixing angle. The different Stokes parameters are found to increase linearly with the number of domains. We also verify this result by direct numerical simulations. We use this formalism to estimate the effect of pseudoscalar-photon mixing on the Cosmic Microwave Background (CMB) polarization. We impose limits on the model parameters by the CMB observations. We find that the currently allowed parameter range admits a CMB circular polarization up to order 10710^{-7}.Comment: 17 pages, 5 figure

    Locality of quark-hadron duality and deviations from quark counting rules above resonance region

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    We show how deviations from the dimensional scaling laws for exclusive processes may be related to a breakdown in the locality of quark-hadron duality. The essential principles are illustrated in a pedagogic model of a composite system with two spinless charged constituents, for which a dual picture for the low-energy resonance phenomena and high-energy scaling behavior can be established. We introduce the concept of "restricted locality" of quark-hadron duality and show how this results in deviations from the pQCD quark counting rules above the resonance region. In particular it can be a possible source for oscillations about the smooth quark counting rule, as seen e.g. in the 90-degree differential cross sections for γpπ+n\gamma p\to \pi^+ n.Comment: The way to present Eqs. (2), (4), (7) are changed while physics contents and calculations are left intact; Additional explanations for the forward and large-angle duality are added; Three more references are included; Version to appear on Phys. Rev. Let

    Comparative study of radio pulses from simulated hadron-, electron-, and neutrino-initiated showers in ice in the GeV-PeV range

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    High energy particle showers produce coherent Cherenkov radio emission in dense, radio-transparent media such as cold ice. Using PYTHIA and GEANT simulation tools, we make a comparative study among electromagnetic (EM) and hadronic showers initiated by single particles and neutrino showers initiated by multiple particles produced at the neutrino-nucleon event vertex. We include all the physics processes and do a complete 3-D simulation up to 100 TeV for all showers and to 1 PeV for electron and neutrino induced showers. We calculate the radio pulses for energies between 100 GeV and 1 PeV and find hadron showers, and consequently neutrino showers, are not as efficient below 1 PeV at producing radio pulses as the electromagnetic showers. The agreement improves as energy increases, however, and by a PeV and above the difference disappears. By looking at the 3-D structure of the showers in time, we show that the hadronic showers are not as compact as the EM showers and hence the radiation is not as coherent as EM shower emission at the same frequency. We show that the ratio of emitted pulse strength to shower tracklength is a function only of a single, coherence parameter, independent of species and energy of initiating particle.Comment: a few comments added, to bo published in PRD Nov. issue, 10 pages, 3 figures in tex file, 3 jpg figures in separate files, and 1 tabl

    Magnetization screening from gluonic currents and scaling law violation in the ratio of magnetic form factors for neutron and proton

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    The ratio μpGEp/GMp{\mu_p}G_E^p/G_M^p exhibits a decrease for four-momentum transfer Q^2 increasing beyond 1 GeV^2 indicating different spatial distributions for charge and for magnetization inside the proton. One-gluon exchange currents can explain this behaviour. The SU(6) breaking induced by gluonic currents predicts furthermore that the ratio of neutron to proton magnetic form factors μpGMn/μnGMp{\mu_p}G_M^n/{\mu_n}G_M^p falls with increasing Q^2. We find that the experimental data are consistent with our expectations of an almost linear decrease of the ratio μpGMn/μnGMp{\mu_p}G_M^n/{\mu_n}G_M^p with increasing Q^2, supporting the statement that the spatial distributions of magnetization are different for protons and for neutrons.Comment: 10 pages, 3 figure

    Addendum to "Coherent radio pulses from GEANT generated electromagnetic showers in ice"

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    We reevaluate our published calculations of electromagnetic showers generated by GEANT 3.21 and the radio frequency pulses they produce in ice. We are prompted by a recent report showing that GEANT 3.21-modeled showers are sensitive to internal settings in the electron tracking subroutine. We report the shower and pulse characteristics obtained with different settings of GEANT 3.21 and with GEANT 4. The default setting of electron tracking in GEANT 3.21 we used in previous work speeds up the shower simulation at the cost of information near the end of the tracks. We find that settings tracking electron and positron to lower energy yield a more accurate calculation, a more intense shower, and proportionately stronger radio pulses at low frequencies. At high frequencies the relation between shower tracking algorithm and pulse spectrum is more complex. We obtain radial distributions of shower particles and phase distributions of pulses from 100 GeV showers that are consistent with our published results.Comment: 4 pages, 3 figure

    Nucleon Structure Functions from a Chiral Soliton in the Infinite Momentum Frame

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    We study the frame dependence of nucleon structure functions obtained within a chiral soliton model for the nucleon. Employing light cone coordinates and introducing collective coordinates together with their conjugate momenta, translational invariance of the solitonic quark fields (which describe the nucleon as a localized object) is restored. This formulation allows us to perform a Lorentz boost to the infinite momentum frame of the nucleon. The major result is that the Lorentz contraction associated with this boost causes the leading twist contribution to the structure functions to properly vanish when the Bjorken variable xx exceeds unity. Furthermore we demonstrate that for structure functions calculated in the valence quark approximation to the Nambu--Jona--Lasinio chiral soliton model the Lorentz contraction also has significant effects on the structure functions for moderate values of the Bjorken variable xx.Comment: 16 pages, 1 figure, revised version to be published in Int. J. Mod. Phys.
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