Etnografia terenowa w opuszczonych aglomeracjach północnej Ukrainy. Uwarunkowania wyjazdu do strefy czarnobylskiej na gruncie socjologii jakościowej

Angrosino Michael. 2015. Badania etnograficzne i obserwacyjne. Przeł. M. Brzozowska-Brywczyńska. Warszawa: PWN.Aronson Elliot. 1995. Człowiek Istota Społeczna. Przeł. J. Radzicki. Warszawa: PWN.Banaszkiewicz Magdalena. 2018. Turystyka w miejscach kłopotliwego dziedzictwa. Kraków: Wydawnictwo Uniwersytetu Jagiellońskiego.Berger Peter, Luckmann Thomas. 1983. Społeczne tworzenie rzeczywistości. Warszawa: PIW.Geertz Clifford. 2005. Interpretacja kultur. Wybrane eseje. Przeł. Piechaczek M. M. Kraków: Wydawnictwo Uniwersytetu JagiellońskiegoHensel Przemysław, Glinka Beata. 2012. Teoria ugruntowana. W: Jemielniak D. (red.). Badania jakościowe. Podejścia i teorie, tom 1, Warszawa: PWN: 89-113.Konecki Krzysztof. 2000. Studia z Metodologii Badań Jakościowych: Teoria Ugruntowana. Warszawa: PWN.Ochitowicz Michaił. 1930. „Zamietki po teorii rassienija”, Sowremiennaja Architiektura, za: B. Jałowiecki, M. Szczepański .2006. „Miasto i Przestrzeń w perspektywie socjologicznej”. Warszawa: Scholar.Podemski Krzysztof. 2004. Socjologia podróży. Poznań: Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza w Poznaniu.Pokojska Weronika. 2015. Zapomniane dziedzictwo, czyli Urban Exploring. „Zarządzanie w Kulturze”, 16 (2): 151-163.Rakowicz Piotr. 2017. Tanatoturystyka – niekonwencjonalne wycieczki do opuszczonego miasta Prypeć. Perspektywa socjologiczna. „Miscellanea Anthropologica et Sociologica”, 18 (2): 207-219.Rakowicz Piotr. 2018. Wycieczki do Prypeci i Czarnobyla jako przykład tanatoturystyki. W: Nieroba E., Kopczak – Wirga A. (red. nauk.) Sztuka podróżowania, czyli turysta w świecie kultury, Opole: Wydawnictwo Uniwersytetu Opolskiego: 131-144.Rakowicz Piotr. 2018. Skażone pogranicze Ukrainy i Białorusi w „Chernobyl VR Project”. Próba analizy zjawiska wirtualnej turystyki. W: Culturogical Almanac, Issue 10, Vinnytsia: TVORY: 69-78.Seaton Anthony V. 1996. From Thanatopsis to Thanatourism. Guided by the Dark. „International Journal of Heritage Studies”, 2 (4): 234-244.Strelau Jan. 2014. Psychologia – podręcznik akademicki. Tom 2, Gdańsk: GWPSzacka Barbara. 2003. Wprowadzenie do socjologii. Warszawa: Oficyna Naukowa.Tajfel Henri. 1972. Social Categorization. English MS of La Categorization Social. W: Moscovici S. (red.) Introduction a la psychologie sociale, t. 1, Paris: Larousse.Tanaś Sławoj. 2013. Tanatoturystyka: od przestrzeni śmierci do przestrzeni turystycznej. Łódź: Wydawnictwo Uniwersytetu Łódzkiego.Turner John C. 1982. Towards a Cognitive Redefi nition of the Social Group. W: Tajfel H. (red.) Social Identity and Intergroup Relations, Cambridge: 15-40.alienatours.pl/sylwester_prypec_1985_powrot_do_przeszlosci.php (dostęp 20.03.2019).dazv.gov.ua/en/news-and-media/vitalii-petruk-in-order-to-improve-the-quality-of-service-of-visitors-to-the-exclusion-zone-it-is-necessary-to-adhere-in-cooperation-with-companies-to-all-the-legislative-principles-of-competition.html (dostęp: 26.04.2018).cotiz.org.ua (dostęp: 10.07.2019).nuclear.pl/wiadomosci,news,19012101,0,0.html (dostęp: 20.03.2019).https://www.imdb.com/title/tt7366338/?ref_=fn_al_tt_1 (dostęp: 10.07.2019).14316

Novel Family of Gynecologic Cancer Antigens Detected by Anti-HIV Antibody

Objective: The reactivity of gynecologic cancer proteins with monoclonal antibody (MAb) directed against the human immunodeficiency virus I (HIV-I) was tested

Spinocerebellar ataxia types 1, 2, 3, and 6: disease severity and nonataxia symptoms.

OBJECTIVE: To identify factors that determine disease severity and clinical phenotype of the most common spinocerebellar ataxias (SCAs), we studied 526 patients with SCA1, SCA2, SCA3. or SCA6. METHODS: To measure the severity of ataxia we used the Scale for the Assessment and Rating of Ataxia (SARA). In addition, nonataxia symptoms were assessed with the Inventory of Non-Ataxia Symptoms (INAS). The INAS count denotes the number of nonataxia symptoms in each patient. RESULTS: An analysis of covariance with SARA score as dependent variable and repeat lengths of the expanded and normal allele, age at onset, and disease duration as independent variables led to multivariate models that explained 60.4% of the SARA score variance in SCA1, 45.4% in SCA2, 46.8% in SCA3, and 33.7% in SCA6. In SCA1, SCA2, and SCA3, SARA was mainly determined by repeat length of the expanded allele, age at onset, and disease duration. The only factors determining the SARA score in SCA6 were age at onset and disease duration. The INAS count was 5.0 +/- 2.3 in SCA1, 4.6 +/- 2.2 in SCA2, 5.2 +/- 2.5 in SCA3, and 2.0 +/- 1.7 in SCA6. In SCA1, SCA2, and SCA3, SARA score and disease duration were the strongest predictors of the INAS count. In SCA6, only age at onset and disease duration had an effect on the INAS count. CONCLUSIONS: Our study suggests that spinocerebellar ataxia (SCA) 1, SCA2, and SCA3 share a number of common biologic properties, whereas SCA6 is distinct in that its phenotype is more determined by age than by disease-related factors

Evidence for a relatively high proportion of DM2 mutations in a large group of Polish patients

Introduction: Myotonic dystrophies (DMs) type 1 (DM1) and type 2 (DM2) are autosomal dominant, multisystem disorders, considered the most common dystrophies in adults. DM1 and DM2 are caused by dynamic mutations in the DMPK and CNBP genes, respectively. Methods: Molecular analyses were performed by PCR and the modified RP-PCR in patients, in their at-risk relatives and prenatal cases. Results: The analysis of Polish controls revealed the range of 5-31 CTG repeats for DM1 and 110-228 bp alleles for DM2. Among 318 confirmed probands - 196 (62%) were DM1 and 122 (38%) – DM2. Within DM1families, 10 subjects carried a low expanded CTG tract (< 100 repeats), which resulted in a full mutation in subsequent generations. Two related individuals had unstable alleles–188 bp and 196 bp without common interruptions. Conclusion: The relative frequencies of DM1/DM2 among Polish patients were 68% and 32%, respectively, with a relatively high proportion of DM2 mutations (1.6:1)

The personal experience of parenting a child with Juvenile Huntington’s Disease: perceptions across Europe

The study reported here presents a detailed description of what it is like to parent a child with juvenile Huntington’s disease in families across four European countries. Its primary aim was to develop and extend findings from a previous UK study. The study recruited parents from four European countries: Holland, Italy, Poland and Sweden,. A secondary aim was to see the extent to which the findings from the UK study were repeated across Europe and the degree of commonality or divergence across the different countries. Fourteen parents who were the primary caregiver took part in a semistructured interview. These were analyzed using an established qualitative methodology, interpretative phenomenological analysis. Five analytic themes were derived from the analysis: the early signs of something wrong; parental understanding of juvenile Huntington’s disease; living with the disease; other people’s knowledge and understanding; and need for support. These are discussed in light of the considerable convergence between the experiences of families in the United Kingdom and elsewhere in Europe

Early symptoms in spinocerebellar ataxia type 1, 2, 3, and 6.

Abstract: Onset of genetically determined neurodegenerative diseases is difficult to specify because of their insidious and slowly progressive nature. This is especially true for spinocerebellar ataxia (SCA) because of varying affection of many parts of the nervous system and huge variability of symptoms. We investigated early symptoms in 287 patients with SCA1, SCA2, SCA3, or SCA6 and calculated the influence of CAG repeat length on age of onset depending on (1) the definition of disease onset, (2) people defining onset, and (3) duration of symptoms. Gait difficulty was the initial symptom in two-thirds of patients. Double vision, dysarthria, impaired hand writing, and episodic vertigo preceded ataxia in 4% of patients, respectively. Frequency of other early symptoms did not differ from controls and was regarded unspecific. Data about disease onset varied between patients and relatives for 1 year or more in 44% of cases. Influence of repeat length on age of onset was maximum when onset was defined as beginning of permanent gait disturbance and cases with symptoms for more than 10 years were excluded. Under these conditions, CAG repeat length determined 64% of onset variability in SCA1, 67% in SCA2, 46% in SCA3, and 41% in SCA6 demonstrating substantial influence of nonrepeat factors on disease onset in all SCA subtypes. Identification of these factors is of interest as potential targets for disease modifying compounds. In this respect, recognition of early symptoms that develop before onset of ataxia is mandatory to determine the shift from presymptomatic to affected status in SCA

Nuclear localization and function of polypeptide ligands and their receptors: a new paradigm for hormone specificity within the mammary gland?

The specific effects triggered by polypeptide hormone/growth factor stimulation of mammary cells were considered mediated solely by receptor-associated signaling networks. A compelling body of new data, however, clearly indicates that polypeptide ligands and/or their receptors are transported into the nucleus, where they function directly to regulate the expression of specific transcription factors and gene loci. The intranuclear function of these complexes may contribute to the explicit functions associated with a given ligand, and may serve as new targets for pharmacologic intervention

Participant experiences of guided self-help Acceptance and Commitment Therapy for improving quality of life in muscle disease : a nested qualitative study within the ACTMus randomized controlled trial

In adults, muscle disease (MD) is typically a chronic long-term condition that can lead to a reduced quality of life (QoL). Previous research suggests that a psychological intervention, in particular Acceptance and Commitment Therapy (ACT), may help improve QoL for individuals living with chronic conditions such as MD. This nested qualitative study was incorporated within a randomised controlled trial which evaluated a guided self-help ACT intervention for people living with MD to explore their experiences of the intervention. Semi-structured interviews (n = 20) were conducted with those who had received ACT. Data were analysed via thematic analysis. There were four overarching themes. 1) Views on whether therapy sessions would help with a medical condition: participants’ expectations regarding ACT varied. Some participants were skeptical about mindfulness. 2) I was able to look at things in a different way: participants described increased meaningful activity, greater awareness of thoughts and emotions and acceptance or adaptation to mobility problems. Some described improvement in the quality of relationships and a sense of feeling free. 3) Treating the body and the mind together: following the intervention participants noted that a holistic approach to healthcare is beneficial. 4) Intervention delivery: The remote delivery was generally seen as helpful for practical reasons and allowed participants to speak openly. Participants voiced a need for follow-up sessions. Overall, the intervention was experienced as acceptable. Suggested improvements included de-emphasising the role of mindfulness and adding follow-up sessions

Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice

With molecular treatments coming into reach for spinocerebellar ataxia type 3 (SCA3), easily accessible, cross-species validated biomarkers for human and preclinical trials are warranted, particularly for the preataxic disease stage. We assessed serum levels of neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) in ataxic and preataxic subjects of two independent multicentric SCA3 cohorts and in a SCA3 knock-in mouse model. Ataxic SCA3 subjects showed increased levels of both NfL and pNfH. In preataxic subjects, NfL levels increased with proximity to the individual expected onset of ataxia, with significant NfL elevations already 7.5 years before onset. Cross-sectional NfL levels correlated with both disease severity and longitudinal disease progression. Blood NfL and pNfH increases in human SCA3 were each paralleled by similar changes in SCA3 knock-in mice, here also starting already at the presymptomatic stage, closely following ataxin-3 aggregation and preceding Purkinje cell loss in the brain. Blood neurofilaments, particularly NfL, might thus provide easily accessible, cross-species validated biomarkers in both ataxic and preataxic SCA3, associated with earliest neuropathological changes, and serve as progression, proximity-to-onset and, potentially, treatment-response markers in both human and preclinical SCA3 trials