4 research outputs found
The Amine Content of PEGylated Chitosan Bombyx mori Nanoparticles Acts as a Trigger for Protein Delivery
In modern medicine, effective protein therapy is a major challenge to which a significant contribution can be expected from nanoscience through the development of novel delivery systems. Here we present the effect of the amine content of nanoparticles based on PEGylated chitosan Bombyx mori (PEG-O-ChsBm) copolymers on the entrapment of molecules in a search for highly efficient,nanocarriers. PEG-O-ChsBm copolymers were synthesized with amine contents from 1.12% to 0.70%, and nanoparticles were generated by self-assembly in dilute aqueous solutions. These nanoparticles successfully entrapped molecules with a wide range of sizes, the efficiency of which was dependent on their amine contents. While hydrophobic molecules were entrapped with high efficiency in all types of nanoparticle, hydrophilic molecules were entrapped only in those with low amine content. Bovine serum albumin, selected as a model protein, was entrapped in nanoparticles and efficiently released in acidic conditions. The triggered entrapment of molecules in PEG-O-ChsBm nanoparticles by selection of the appropriate amine content represents a straightforward way to modulate their delivery by fine changes in the properties of nanocarriers
The Amine Content of PEGylated Chitosan <i>Bombyx mori</i> Nanoparticles Acts as a Trigger for Protein Delivery
In
modern medicine, effective protein therapy is a major challenge
to which a significant contribution can be expected from nanoscience
through the development of novel delivery systems. Here we present
the effect of the amine content of nanoparticles based on PEGylated
chitosan <i>Bombyx mori</i> (PEG-O-ChsBm) copolymers
on the entrapment of molecules in a search for highly efficient nanocarriers.
PEG-O-ChsBm copolymers were synthesized with amine contents from 1.12%
to 0.70%, and nanoparticles were generated by self-assembly in dilute
aqueous solutions. These nanoparticles successfully entrapped molecules
with a wide range of sizes, the efficiency of which was dependent
on their amine contents. While hydrophobic molecules were entrapped
with high efficiency in all types of nanoparticle, hydrophilic molecules
were entrapped only in those with low amine content. Bovine serum
albumin, selected as a model protein, was entrapped in nanoparticles
and efficiently released in acidic conditions. The triggered entrapment
of molecules in PEG-O-ChsBm nanoparticles by selection of the appropriate
amine content represents a straightforward way to modulate their delivery
by fine changes in the properties of nanocarriers
The Amine Content of PEGylated Chitosan <i>Bombyx mori</i> Nanoparticles Acts as a Trigger for Protein Delivery
In
modern medicine, effective protein therapy is a major challenge
to which a significant contribution can be expected from nanoscience
through the development of novel delivery systems. Here we present
the effect of the amine content of nanoparticles based on PEGylated
chitosan <i>Bombyx mori</i> (PEG-O-ChsBm) copolymers
on the entrapment of molecules in a search for highly efficient nanocarriers.
PEG-O-ChsBm copolymers were synthesized with amine contents from 1.12%
to 0.70%, and nanoparticles were generated by self-assembly in dilute
aqueous solutions. These nanoparticles successfully entrapped molecules
with a wide range of sizes, the efficiency of which was dependent
on their amine contents. While hydrophobic molecules were entrapped
with high efficiency in all types of nanoparticle, hydrophilic molecules
were entrapped only in those with low amine content. Bovine serum
albumin, selected as a model protein, was entrapped in nanoparticles
and efficiently released in acidic conditions. The triggered entrapment
of molecules in PEG-O-ChsBm nanoparticles by selection of the appropriate
amine content represents a straightforward way to modulate their delivery
by fine changes in the properties of nanocarriers