Requirement of ESWL after ureterorenoscopy and lithotripsy in the management of upper ureteric stone: comparison between Holmium Yag laser and pneumatic lithotripsy in a referral hospital, Bangladesh

Various methods have been employed for the removal of ureteric calculi all over the world. Both Ureteroscopic Pneumatic and Laser lithotripsy are popular procedures for this purpose. However proximal migration of stone fragments are not uncommon in these procedures while treating upper ureteric stones. Extra corporeal shock wave lithotripsy (ESWL) may require to fragment those proximally migrated stones after the ureteroscopic Pneumatic or Laser lithotripsy. To compare the requirement of ESWL in the management of ureteric stone between Holmium Yag Laser and Pneumatic Lithotripsy. This study included 100 patients with upper ureteric stones who underwent ureteroscopic lithotripsy at the Department of Urology, CMH, Dhaka, between October 2010 and September 2012. Laser lithotripsy was used in 50 patients (Group A), and pneumatic lithotripsy was used in the remaining 50 patients (Group B). In each case, the same ureteroscope, video monitor, baskets, or irrigation devices were used. A kidney ureter and bladder radiograph and ultrasonograph were performed on patients one month and three months after lithotripsy. Patients with migrated fragments or insufficient clearance underwent a supplementary procedure such as ESWL. Mean age was 41.9}10.9 years and 41.3}12.3 years in Group A and Group B respectively. Males were predominant in both groups. Mean stone size was 1.36 } 0.36 cm in Group A and 1.37} 0.36 cm in Group B. Complete stone clearance was 94.0% in Group A and 76.0% in Group B. EWSL requirement rate was significantly higher in Group B (24.0%) than Group A (6.0%). Peri procedural complications like hemorrhage was significantly higher in Group B and mucosal disruption/perforation was almost same in both the groups. EWSL requirement rate was comparatively higher in pneumatic lithotripsy than laser lithotripsy. BSMMU J 2022; 15(2): 111-11

Full Length Research Paper Arsenic Contamination: Food Toxicity and Local Perception

Abstract. This study was performed based on local perception on arsenic toxicity with respect to socioeconomic status at the Achintanagar village in the southwestern part of Bangladesh. The questionnaire was distributed randomly at the local scale in the study area. It was found that the respondents are highly contaminated with arsenic and most of them have suffered from economic crisis and ignorance. Arsenic contamination and food poisoning concept has direct bearing on educational level which is emphasized on socioeconomic status. Correlation coefficient matrix had revealed that the whole aspects of socioeconomic component negatively correlated with arsenic toxicity for group one and two. Female participant were observed to be more unconscious than male respondents on food contamination through arsenic accumulation. Results showed that, most of the respondents continued to eat and practiced the sale of contaminated food in the community. It was observed that this practice is highly contagious for human and environmental health

Online Purchasing Behavior among Bangladeshi Young Generation: Influencing Factors and Impact

Online shopping is a genius that is developing quickly these days. There is as yet an important piece of market potential for online based business in spite of the expansion of the primary players in this industry. Therefore, this investigation looks at the variables influencing on client's conduct of internet shopping that may be a pivotal part of online business and showcasing industry. However, this is a requesting social pattern and there are numerous reasons it was excessively troublesome, making it impossible to discover about online shopper conduct. The reason for this examination is to manage the shortcomings of internet shopping conduct that the past investigation did not assess yet. This goal is utilizing a model by looking at the effect of Financial Risk, Product Risk, Convenience Risk, Non-delivery Risk, and Return Policy on state of mind toward web based shopping conduct of purchasers as the speculations of study. Straightforward irregular examining polls were dispersed to 200 online stores of Bangladesh. At long last, every one of the information was gathered and relapse investigation was utilized to test the theories of the exploration. Additionally, the discoveries confirmed that both money related risk and non-conveyance chance have negative impacts in web based shopping, and the examination likewise connoted that specific framework advancement and individual standards have a constructive outcome web based shopping conduct. What's more, the demeanour has decidedly influenced client's online based shopping conduct

Novel therapeutics against breast cancer stem cells by targeting surface markers and signaling pathways

Background: Breast cancer remains to be one of the deadliest forms of cancers, owing to the drug resistance and tumor relapse caused by breast cancer stem cells (BCSCs) despite notable advancements in radio-chemotherapies. Objectives: To find out novel therapeutics against breast cancer stem cells by aiming surface markers and signaling pathways. Methods: A systematic literature search was conducted through various electronic databases including, Pubmed, Scopus, Google scholar using the keywords "BCSCs, surface markers, signaling pathways and therapeutic options against breast cancer stem cell. Articles selected for the purpose of this review were reviewed and extensively analyzed. Results: Novel therapeutic strategies include targeting BCSCs surface markers and aberrantly activated signaling pathways or targeting their components, which play critical roles in self-renewal and defense, have been shown to be significantly effective against breast cancer. In this review, we represent a number of ways against BCSCs surface markers and hyper-activated signaling pathways to target this highly malicious entity of breast cancer more effectively in order to make a feasible and useful strategy for successful breast cancer treatment. In addition, we discuss some characteristics of BCSCs in disease progression and therapy resistance. Conclusion: BCSCs involved in cancer pathogenesis, therapy resistance and cancer recurrence. Thus, it is suggested that a multi-dimensional therapeutic approach by targeting surface markers and aberrantly activated signaling pathways of BCSCs alone or in combination with each other could really be worthwhile in the treatment of breast cancer

Natural compounds targeting cancer stem cells: a promising resource for chemotherapy

Background: Cancer Stem Cells (CSCs) are the subpopulation of cancer cells which are directly involved in drug resistance, metastases to distant organ and cancer recurrence.Methods: A systematic literature search was conducted through various electronic databases including, Pubmed, Scopus, Google scholar using the keywords "cancer stem cells" and "natural compounds" in the present study. Articles published between 1999 and 2019 were reviewed. All the expositions concerning CSCs associated cancer pathogenesis and therapy resistance, as well as targeting these properties of CSCs by natural compounds were selected for the current study.Results: Natural compounds have always been thought as a rich source of biologically active principles, which target aberrantly activated signaling pathways and other modalities of CSCs, while tethering painful side effects commonly involved in the first-line and second-line chemo-radiotherapies. In this review, we have described the key signaling pathways activated in CSCs to maintain their survival and highlighted how natural compounds interrupt these signaling pathways to minimize therapy resistance, pathogenesis and cancer recurrence properties of CSCs, thereby providing useful strategies to treat cancer or aid in cancer therapy improvement. Like normal stem cells, CSCs rely on different signaling pathways and other properties for their maintenance. Therefore, the success of cancer treatment depends on the development of proper anti-neoplastic drugs capable of intercepting those signaling pathways as well as other properties of CSCs in order to eradicate this evasive subpopulation of cancer cells.Conclusion: Compounds of natural origin might act as an outstanding source to design novel therapies against cancer stem cells

Antiproliferative Action of Conjugated Linoleic Acid on Human MCF-7 Breast Cancer Cells Mediated by Enhancement of Gap Junctional Intercellular Communication through Inactivation of NF-κB

The major conjugated linoleic acid (CLA) isomers, c9,t11-CLA and t10,c12-CLA, have anticancer effects; however, the exact mechanisms underlying these effects are unknown. Evidence suggests that reversal of reduced gap junctional intercellular communication (GJIC) in cancer cells inhibits cell growth and induces cell death. Hence, we determined that CLA isomers enhance GJIC in human MCF-7 breast cancer cells and investigated the underlying molecular mechanisms. The CLA isomers significantly enhanced GJIC of MCF-7 cells at 40 μM concentration, whereas CLA inhibited cell growth and induced caspase-dependent apoptosis. CLA increased connexin43 (Cx43) expression both at the transcriptional and translational levels. CLA inhibited nuclear factor-κB (NF-κB) activity and enhanced reactive oxygen species (ROS) generation. No significant difference was observed in the efficacy of c9,t11-CLA and t10,c12-CLA. These results suggest that the anticancer effect of CLA is associated with upregulation of GJIC mediated by enhanced Cx43 expression through inactivation of NF-κB and generation of ROS in MCF-7 cells