SIMULTANEOUS METHOD DEVELOPMENT AND VALIDATION OF CHOLINE SALICYLATE AND TANNIC ACID USING RP-HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORM

Objective: The current investigation was pointed at completely unique and reliable high performance liquid chromatographic method for simultaneous quantification of Choline salicylate and Tannic acid. Methods: Chromatographic separation was achieved on a symmetry C18 column (150x4.6mm, 3.5 µ) using isocratic elution with a buffer containing 1 ml of OPA in l lt of HPLC marked water and acetonitrile within the percentage of 60:40 as movable phase with a flow rate of 1.0 ml/min at ambient temperature. Analysis was achieved within 15 min over an honest linearity within the concentration range from 4-60 µg/ml of choline salicylate and 2.5-37.5 µg/ml of tannic acid. Stress conditions of degradation in acidic, alkaline, peroxide and thermal was studied.  Results: LOD and LOQ were observed as 1.21 µg/ml, 0.758 µg/ml and 4 µg/ml, 2.5 µg/ml of choline salicylate and tannic acid respectively. Precision and recovery study results were found to be within the suitable limit. Conclusion: This developed method showed reliable, precise, accurate results under optimized conditions. The method was validated as reported by ICH guidelines. Hence it was evident that the proposed method was suitable for regular analysis and quality control of pharmaceutical preparations

Explorations in urban resilience for a post-hydrocarbon economy.

Aberdeen presents a unique context for its school of architecture, and a set of conditions that define much of its identity and enquiry. The city's economic base is dominated by the hydrocarbon industry, which generates particular issues of long-term socioeconomic sustainability and urban development that are of local and wider relevance. The theme of urban resilience from an economic perspective is particularly pertinent, as highlighted by the volatility of the oil and gas industry in the last year. Applying processes of partnership and community engagement, the Masters students at RGU have consistently explored the theme of urban resilience, through its unique two-year single project structure. This paper introduces the processes involved in this work, and discusses two key areas of particular significance: the thesis structure and its attendant benefits; and the contribution that the school makes through its work to political and community debate about the city's posthydrocarbon future

Implementation of soft processor based SOC for JPEG compression on FPGA

With the advent of semiconductor process and EDA tools technology, IC designers can integrate more functions. However, to reduce the demand of time-to-market and tackle the increasing complexity of SoC, the need of fast prototyping and testing is growing. Taking advantage of deep submicron technology, modern FPGAs provide a fast and low-cost prototyping with large logic resources and high performance. So the hardware is mapped onto an emulation platform based on FPGA that mimics the behaviour of SOC. In this paper we use FPGA as a system on chip which is then used for image compression by 2-D DCT respectively and proposed SoC for image compression using soft core Microblaze. The JPEG standard defines compression techniques for image data. As a consequence, it allows to store and transfer image data with considerably reduced demand for storage space and bandwidth. From the four processes provided in the JPEG standard, only one, the baseline process is widely used. Proposed SoC for JPEG compression has been implemented on FPGA Spartan-6 SP605 evaluation board using Xilinx platform studio, because field programmable gate array have reconfigurable hardware architecture. Hence the JPEG image with high speed and reduced size can be obtained at low risk and low power consumption of about 0.699W. The proposed SoC for image compression is evaluated at 83.33MHz on Xilinx Spartan-6 FPGA

Effectiveness of English Multimedia Assisted Instructional Package in Enhancing Achievement in English among Standard IX Students in Relation to their Interest in Learning

According to today’s pedagogical practices, the key to engagement of students and the effectiveness of the procedure is through ICT. This paper analyses the implications that multimedia assisted instructional package have in enhancing the achievement of Class IX students in learning. The paper envisages that the application of ICT in pedagogy can enhance the interest of students in English Learning

Implementation of dual stack technique for reducing leakage and dynamic power

This paper deals with proposal of a new dual stack approach for reducing both leakage and dynamic powers. The development of digital integrated circuits is challenged by higher power consumption. Thecombination of higher clock speeds, greater functional integration, and smaller process geometries has contributed to significant growth in power density. Scaling improves transistor density and functionality ona chip. Scaling helps to increase speed and frequency of operation and hence higher performance. As voltages scale downward with the geometries threshold voltages must also decrease to gain the performance advantages of the new technology but leakage current increases exponentially. Today leakage power has become anincreasingly important issue in processor hardware and software design. It can be used in various applications like digital VLSI clocking system, buffers, registers, microprocessors etc. The leakage power increases astechnology is scaled down. In this paper, we propose a new dual stack approach for reducing both leakage and dynamic powers. Moreover, the novel dual stack approach shows the least speed power product whencompared to the existing methods. All well known approach is “Sleep” in this method we reduce leakage power. The proposed Dual Stack approach we reduce more power leakage. Dual Stack approach uses theadvantage of using the two extra pull-up and two extra pull-down transistors in sleep mode either in OFF state or in ON state. Since the Dual Stack portion can be made common to all logic circuitry, less number of transistors is needed to apply a certain logic circuit.The dual stack approach shows the least speed power product among all methods. The Dual Stack technique provides new ways to designers who require ultra-low leakage power consumption with much less speedpower product

Weld Residual Stress and Distortion Analysis of the ARES I-X Upper Stage Simulator (USS)

An independent assessment was conducted to determine the critical initial flaw size (CIFS) for the flange-to-skin weld in the Ares I-X Upper Stage Simulator (USS). The Ares system of space launch vehicles is the US National Aeronautics and Space Administration s plan for replacement of the aging space shuttle. The new Ares space launch system is somewhat of a combination of the space shuttle system and the Saturn launch vehicles used prior to the shuttle. Here, a series of weld analyses are performed to determine the residual stresses in a critical region of the USS. Weld residual stresses both increase constraint and mean stress thereby having an important effect on fatigue and fracture life. While the main focus of this paper is a discussion of the weld modeling procedures and results for the USS, a short summary of the CIFS assessment is provided

David Dexter Perkins (1919-2007)

Obituary of David Dexter Perkin

Interaction of Alpha-Crystallin with Four Major Phospholipids of Eye Lens Membranes

It is well-studied that the significant factor in cataract formation is the association of α-crystallin, a major eye lens protein, with the fiber cell plasma membrane of the eye lens. The fiber cell plasma membrane of the eye lens consists of four major phospholipids (PLs), i.e., phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), and sphingomyelin (SM). Despite several attempts to study the interaction of α-crystallin with PLs of the eye lens membrane, the role of individual PL for the binding with α-crystallin is still unclear. We recently developed the electron paramagnetic resonance (EPR) spin-labeling method to study the binding of α-crystallin to the PC membrane (Mainali et al., 2020a). Here, we use the recently developed EPR method to explicitly measure the binding affinity (Ka) of α-crystallin to the individual (PE*, PS, and SM) and two-component mixtures (SM/PE, SM/PS, and SM/PC in 70:30 and 50:50 mol%) of PL membranes as well as the physical properties (mobility parameter and maximum splitting) of these membranes upon binding with α-crystallin. One of the key findings of this study was that the Ka of α-crystallin binding to individual PL membranes followed the trends: Ka(PC) \u3e Ka(SM) \u3e Ka(PS) \u3e Ka(PE*), indicating PE* inhibits binding the most whereas PC inhibits binding the least. Also, the Ka of α-crystallin binding to two-component mixtures of PL membranes followed the trends: Ka(SM/PE) \u3e Ka(SM/PS) \u3e Ka(SM/PC), indicating SM/PC inhibits binding the most whereas SM/PE inhibits binding the least. Except for the PE* membrane, for which there was no binding of α-crystallin, the mobility parameter for all other membranes decreased with an increase in α-crystallin concentration. It represents that the membranes become more immobilized near the headgroup regions of the PLs when more and more α-crystallin binds to them. The maximum splitting increased only for the SM and the SM/PE (70:30 mol%) membranes, with an increase in the binding of α-crystallin. It represents that the PL headgroup regions of these membranes become more ordered after binding of α-crystallin to these membranes. Our results showed that α-crystallin binds to PL membranes in a saturable manner. Also, our data suggest that the binding of α-crystallin to PL membranes likely occurs through hydrophobic interaction between α-crystallin and the hydrophobic fatty acid core of the membranes, and such interaction is modulated by the PL headgroup’s size and charge, hydrogen bonding between headgroups, and PL curvature. Thus, this study provides an in-depth understanding of α-crystallin interaction with the PL membranes made of individual and two-component mixtures of the four major PLs of the eye lens membranes

Big Red, Ltd.

This case addresses two frequently heard questions in real-world business settings: “Why are sales going down?” and “What decisions must we make to reverse the sales decline?” These questions were directed to Dr. Felix Wilder, a professor of Marketing, by the senior management of Big Red, Ltd., headquartered in Waco, Texas, after sales reports indicated a significant decline in year-over-year sales in the Louisville, Kentucky, market region. This region represented one of Big Red’s most important market areas for soft drinks outside of its home base in Texas. Members of Big Red’s senior management team were unable to identify the specific factors that had contributed to the sales decline. As a result, they commissioned Dr. Wilder to conduct an extensive marketing research project to determine the factors contributing to the erosion in sales. Dr. Wilder proposed a multifaceted exploratory research project that involved an extensive review of industry and trade literature, in-depth interviews with grocery store and super center store managers, an in-store consumer survey of Big Red customers, and a consumer focus group. The research design focused on the marketing mix variables, environmental factors, the target market, and changing consumer purchase behavior and lifestyle issues as possible sources contributing to the sales erosion. The results of Dr. Wilder’s investigation conflicted with Big Red management’s preliminary hypotheses and revealed unexpected factors that may have contributed to the downward drift in sales.  Based on the research, Dr. Wilder presented management with various alternative courses of action to correct the sales decline.