PROPOSE OF PROTECTED NETWORK FOR INDUSTRIAL ORGANIZE SCHEME USING IOT TECHNOLOGY

Supervisory control and also information purchase (SCADA) systems, become part of commercial control system (ICS), have actually been playing vital duties in real-time commercial automation as well as controls. Via the development of 3rd generation, or networks based system, SCADA systems are linked to virtually kinds of networks such as wired, cordless, as well as mobile as well as satellite interaction, however safety and security is still a huge difficulty for SCADA system while interacting within. Web of points (IoT) is a common system, a brand-new breakthrough improvement, for reliable SCADA system, where billions of network tools, with wise picking up abilities, are networked online gain access to. Implementation of wise IoT system, SCADA system will substantially enhance system effectiveness, scalability, and also lower expense. Protection is still a significant concern for both-, as they were originally developed with no concern as well as demands of safety. This research study designed IoT-SCADA system as well as released a safety and security system, using of cryptography based formula, which supplied a protected transmission network while each time interaction happened, in between the area tools in the SCADA system

Performance evaluation of a manually operated paddy drum seeder - a cost saving technology for paddy cultivation

 A study was conducted at farmer field to evaluate performance of mechanized paddy cultivation (T1), mechanized paddy cultivation with incorporation of Dhaincha before direct sowing of paddy seed (T2) and the traditional farmer practice (T3).  Consecutive three years of data were obtained for analysis and different crop growth parameters were measured like panicle length, number of tillers, grain yield etc. for each treatment.  It was found that the average grain yield for three years in different treatments T1 and T2 was enhanced by 10% and 14% respectively when compared with farmer practice.  Average cost of cultivation was reduced by 25% in treatment T2 where green manuring crop (Dhaincha) was grown and incorporated in soil with indigenous plough before paddy seeding.  Study also revealed that due to mechanized cultivation practices, the crop was ready to harvest eight to ten days early than farmer’s practices.  The experiment well proved to raise the socio-economic status of the farmers by changing their strategy towards mechanized organic paddy cultivation.   Keywords: drum seeder, mechanization, green manuring crop, growth parameters

Micropropagation of Crotalaria laburnifolia L. – An ethnomedicinally important herbal species

A protocol for in vitro shoot multiplication in Crotalaria labumifolia L. through nodal explants was established. Excision and culture of the nodal segments from in vitro developed shoots on fresh MS medium with concentration of BA (1mg/1) facilitated development of multiple shoots. Subsequent cultures enhanced the rate of shoot proliferation. Shoots cultured on ½ MS medium containing NAA (0.5 mg/1) initiated roots well compared with IBA and this is the most suitable protocol studied in C. labumifolia. The present study is the first report on in vitro regeneration in this species&nbsp

Critical assessment of the efficiency of chitosan biohydrogel beads as recyclable and heterogeneous organocatalyst for C–C bond formation

The effectiveness of neutral pH chitosan hydrogel beads (CSHB) as a green organocatalyst for a variety of C–C bond forming reactions (i.e. aldol reaction, Knoevenagel condensation, nitroaldol (Henry) reaction, Michael addition) has been comprehensively evaluated. Reaction rates, conversions and selectivities were studied as a function of a series of input variables including size, pH and reactive surface area of the beads, catalyst loading, temperature, molecular weight of the biopolymer, concentration, solvent system and molar ratio of reactants. Moreover, the catalytic biohydrogel beads were characterized by a variety of techniques including, among others, SEM, FT-IR, TGA and DSC

The Evolving Profile of Idiosyncratic Drug-Induced Liver Injury

Funding Information: Conflicts of interest This author discloses the following: Rajender Reddy has received grant/research support from BMS, EXACT Sciences, NASH-TARGET, HCC-TARGET, Intercept, Mallinckrodt, Grifols, Sequana, and BioVie; serves on advisory committee/review panel for Mallinckrodt, NovoNordisk, Genfit, and Spark Therapeutics; and Data and Safety Monitoring Board from Novartis and Astra Zeneca. The remaining authors disclose no conflicts. Publisher Copyright: © 2023 AGA InstituteIdiosyncratic drug-induced liver injury (DILI) is an infrequent but important cause of liver disease. Newly identified causes of DILI include the COVID vaccines, turmeric, green tea extract, and immune checkpoint inhibitors. DILI is largely a clinical diagnosis of exclusion that requires evaluation for more common causes of liver injury and a compatible temporal association with the suspect drug. Recent progress in DILI causality assessment includes the development of the semi-automated revised electronic causality assessment method (RECAM) instrument. In addition, several drug-specific HLA associations have been identified that can help with the confirmation or exclusion of DILI in individual patients. Various prognostic models can help identify the 5%-10% of patients at highest risk of death. Following suspect drug cessation, 80% of patients with DILI fully recover, whereas 10%-15% have persistently abnormal laboratory studies at 6 months of follow-up. Hospitalized patients with DILI with an elevated international normalized ratio or mental status changes should be considered for N-acetylcysteine therapy and urgent liver transplant evaluation. Selected patients with moderate to severe drug reaction with eosinophilia and systemic symptoms or autoimmune features on liver biopsy may benefit from short-term corticosteroids. However, prospective studies are needed to determine the optimal patients and dose and duration of steroids to use. LiverTox is a comprehensive, freely accessible Web site with important information regarding the hepatotoxicity profile of more than 1000 approved medications and 60 herbal and dietary supplement products. It is hoped that ongoing "omics" studies will lead to additional insight into DILI pathogenesis, improved diagnostic and prognostic biomarkers, and mechanism-based treatments.Peer reviewe

Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome

Background & Aims: It is not known if specific characteristics of medication are associated with type of drug-induced liver injury (DILI) or outcome. We examined the relationships among select characteristics of medications and DILI phenotype and outcome. Methods: We analyzed 383 cases of DILI caused by a single orally administered prescription agent from the DILI Network Prospective Study with causalities of definite, highly likely, or probable. Relationship of daily dosage (≥ 50 mg vs. ≤ 49 mg), preponderance of hepatic metabolism (≥50% vs <50%), or Biopharmaceutics Drug Disposition Classification System (BDDCS) class (1–4, based on solubility and metabolism of the drug) were compared with clinical characteristics and outcomes. Results: Compared to cases of DILI in the <50 mg/day group, those associated with daily dosages ≥50 mg had shorter latency (median 38 days vs 56 days; P=.03) and a different biochemical pattern of liver injury (P=.04); no differences in pattern of injury, recovery, severity, or outcome were observed. Patients with DILI caused by medications with or without preponderant hepatic metabolism did not differ in clinical characteristics or outcomes. Compared to other classes of BDDCS, DILI caused by BDDCS class 1 medications had significantly longer latency (P<.001) and greater proportion of hepatocellular injury (P=.001). However, peak liver biochemical values and patients’ time to recovery, disease severity, and outcomes did not differ among the 4 BDDCS classes. Conclusions: Characteristics of medications (dosage, hepatic metabolism, and solubility) are associated with features of DILI such as latency and pattern of liver injury, but not with recovery, severity, or outcome

Novel compounds as dipeptidyl peptidase IV (dpp iv) inhibitors

The present invention is related to novel compounds of the general formula (A), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds, and their use as Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors, which are useful in the treatment or prevention of diseases particularly Type II diabetes, other complications related to diabetes and other pathogenic conditions in which DPP IV enzyme is involved